期刊
SEMINARS IN HEMATOLOGY
卷 57, 期 4, 页码 213-224出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2020.10.003
关键词
NK cells; NK cell-based cancer immunotherapy; metabolism; glycolysis; OXPHOS; lipid metabolism; CAR
类别
资金
- AECC-Spanish Association Against Cancer [PROYE16074BORR]
- Health Department, Basque Government [2020333024]
- Jesus de Gan-goiti Barrera Foundation [FJGB18/002]
- Department of Education, Basque Government [PRE_2019_2_0109]
- Jesus de Gangoiti Barrera Foundation [FJGB19/002]
- BBK Fundazioa [1543/2006_0 001]
- Instituto de Salud Carlos III-Contratos Sara Borrell [CD17/00128]
- European Social Fund (ESF)
Natural killer (NK) cells are lymphocytes with potent antitumor functions and, therefore, multiple NK cell-based cancer immunotherapies have been developed and are currently being tested. However, there a necessity to find new means to improve these therapies, and immunometabolism represents an attractive target. NK cell effector functions are intricately linked to their metabolism, and modulating the latter could be the key to release their full potential. In this review, we have summarized how NK cell metabolism is regulated during some processes, such as maturation, viral infection, and cytokine stimulation. Additionally, we provide an overview of how NK cell metabolism is affected by current therapeutic approaches aimed to promote NK cell expansion and/or to increase their effector functions. We have also recapitulated several strategies that could help alleviating the metabolic impairment that characterizes tumor-infiltrating NK cells, and thus increase or restore their effector functions. Furthermore, we have reviewed several therapeutic approaches targeting cancer metabolism that could synergize with NK cell based cancer immunotherapies, and thus enhance their efficacy. (C) 2020 The Author(s). Published by Elsevier Inc.
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