The Emerging Roles of Autophagy in Human Diseases

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

(2021) Bálint Mészáros et al.   Science Signaling

Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53

(2021) Jianyu Wang et al.   Cell Death & Disease

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

(2021) Jinyoung Kim et al.   Nature Communications

The interplay between emerging human coronavirus infections and autophagy

(2021) Zhenyu Zhao et al.   Emerging Microbes & Infections

Cancer Stemness: p53 at the Wheel

(2021) Dishari Ghatak et al.   Frontiers in Oncology

Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)

(2021) Xiaoyan Zheng et al.   Autophagy

Pancreatic beta cell autophagy is impaired in type 1 diabetes

(2021) Charanya Muralidharan et al.   DIABETOLOGIA

IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination

(2021) Qingli Bie et al.   ONCOGENE

α-synuclein impairs autophagosome maturation through abnormal actin stabilization

(2021) Souvarish Sarkar et al.   PLoS Genetics

Yeast mitophagy: Unanswered questions

(2021) Yuxiang J. Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

(2021) Emiliano Maiani et al.   NATURE

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

(2021) Alexey Stukalov et al.   NATURE

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

(2021) Manuel Hayn et al.   Cell Reports

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

(2021) Komudi Singh et al.   Frontiers in Genetics

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

Autophagy and Cancer Dormancy

(2021) Yunus Akkoc et al.   Frontiers in Oncology

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

(2021) Benjamin Chun-Kit Tong et al.   Autophagy

Degradation of lipid droplets by chimeric autophagy-tethering compounds

(2021) Yuhua Fu et al.   CELL RESEARCH

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

(2021) Yiwen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-based analysis uncovers mutations altering autophagy selectivity in human cancer

(2021) Zhu Han et al.   Nature Communications

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

(2021) Nils C. Gassen et al.   Nature Communications

TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2

(2021) Joseph D. Trimarco et al.   PLoS Pathogens

Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

(2021) Kai Yu Ma et al.   Translational Neurodegeneration

ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication

(2021) Yafei Qu et al.   Frontiers in Cell and Developmental Biology

Picalm reduction exacerbates tau pathology in a murine tauopathy model

(2020) Kunie Ando et al.   ACTA NEUROPATHOLOGICA

AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

(2020) Irene Benito-Cuesta et al.   Autophagy

Targeting Hsc70-based autophagy to eliminate amyloid β oligomers

(2020) Juan Dou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in animal development

(2020) Elizabeth A. Allen et al.   CELL DEATH AND DIFFERENTIATION

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

(2020) Timothy Marsh et al.   DEVELOPMENTAL CELL

NBR 1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system

(2020) Pablo Sánchez‐Martín et al.   EMBO REPORTS

miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy

(2020) Shinobu Ueda et al.   LABORATORY INVESTIGATION

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

(2020) Jae-Hyeon Park et al.   Molecular Neurodegeneration

LRRK2 in Parkinson disease: challenges of clinical trials

(2020) Eduardo Tolosa et al.   Nature Reviews Neurology

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Beclin 1–ATG14L Protein–Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I

(2020) Ivan Pavlinov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

MitophAging: Mitophagy in Aging and Disease

(2020) Daniela Bakula et al.   Frontiers in Cell and Developmental Biology

Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?

(2020) Patrick Brest et al.   Autophagy

Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancer

(2020) Svetlana Bortnik et al.   BREAST CANCER RESEARCH AND TREATMENT

Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition

(2020) Alicia M. Blessing et al.   CANCER

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

(2020) M. Catarina Silva et al.   Nature Communications

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

(2020) Eric J. Snijder et al.   PLOS BIOLOGY

Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization

(2020) Emelia A. Assar et al.   Frontiers in Cell and Developmental Biology

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

(2020) Julia Obergasteiger et al.   Cell Death Discovery

Identification of required host factors for SARS-CoV-2 infection in human cells

(2020) Zharko Daniloski et al.   CELL

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation

(2020) Young Jin et al.   DIABETES

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase

(2020) Chun‐Kit Yuen et al.   JOURNAL OF MEDICAL VIROLOGY

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

(2020) Tadashi Yamamuro et al.   Nature Communications

Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy

(2020) Shanya Jiang et al.   Frontiers in Molecular Neuroscience

The Roles of Ubiquitin in Mediating Autophagy

(2020) Zhangyuan Yin et al.   Cells

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

(2020) William M. Schneider et al.   CELL

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

(2020) Sourish Ghosh et al.   CELL

A Crisp(r) New Perspective on SARS-CoV-2 Biology

(2020) Adam L. Bailey et al.   CELL

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy

(2020) Silvina Odete Bustos et al.   Frontiers in Oncology

Mitophagy protects β cells from inflammatory damage in diabetes

(2020) Vaibhav Sidarala et al.   JCI Insight

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

(2019) M. Bugliani et al.   Frontiers in Endocrinology

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

(2019) Iván E. Alfaro et al.   Frontiers in Endocrinology

Autophagy in Adipocyte Browning: Emerging Drug Target for Intervention in Obesity

(2019) Seung-Hyun Ro et al.   Frontiers in Physiology

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles

(2019) Truc T. Losier et al.   Cell Reports

Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways

(2019) Tingting Ren et al.   Cell Death & Disease

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

(2019) Vrushank Bhatt et al.   GENES & DEVELOPMENT

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

Ovarian Cancer: An Integrated Review

(2019) Christine Stewart et al.   Seminars in Oncology Nursing

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

(2019) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux

(2019) Enrique Luengo et al.   JOURNAL OF PINEAL RESEARCH

Genome wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor

(2019) Michael J Kerins et al.   MOLECULAR AND CELLULAR BIOLOGY

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

(2019) Christopher J. Shoemaker et al.   PLOS BIOLOGY

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening

(2019) Jiali Deng et al.   Autophagy

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease

(2019) Sarah Jinn et al.   HUMAN MOLECULAR GENETICS

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy

(2019) Tian Guo et al.   Cell Death & Disease

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

(2019) Farah H. Siddiqi et al.   Nature Communications

Brown and Beige Adipose Tissue and Aging

(2019) Elena Zoico et al.   Frontiers in Endocrinology

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

(2019) Rekha Khandia et al.   Cells

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

(2019) Christina G. Towers et al.   DEVELOPMENTAL CELL

Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism

(2019) Xin Qiao et al.   Frontiers in Pharmacology

Targeting Oncogenic BRAF: Past, Present, and Future

(2019) Zaman et al.   Cancers

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

(2019) Daric J. Wible et al.   Cell Discovery

Emerging Roles of Lipophagy in Health and Disease

(2019) Konstantinos Kounakis et al.   Frontiers in Cell and Developmental Biology

Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process

(2019) Mostafa Karimi Roshan et al.   BIOCHIMIE

Astrocyte elevated gene 1 (AEG‐1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma

(2019) Hai‐Dan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

(2019) Alyssa La Belle Flynn et al.   Nature Communications

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

(2019) Benjamin H.M. Hunn et al.   Cell Reports

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

(2019) Alvin Djajadikerta et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Mechanisms and context underlying the role of autophagy in cancer metastasis

(2018) Christopher M. Dower et al.   Autophagy

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

(2018) Javad Alizadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α

(2018) Wei Zhang et al.   BIOCHIMIE

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A

(2018) Claudia Puri et al.   DEVELOPMENTAL CELL

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

TheSalmonellaeffectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication

(2018) Zhao-Zhong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Conformation Polymorphism of Polyglutamine Proteins

(2018) Xinran Feng et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

(2018) Natascha Fussi et al.   Cell Death & Disease

Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival

(2018) Lian Wang et al.   Cell Death & Disease

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

(2018) Miriam García Hernández et al.   Cell Death & Disease

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy

(2018) Hussein F. Aqbi et al.   Oncotarget

Systematic characterization of autophagy-related genes during the adipocyte differentiation using public-access data

(2018) Mahmoud Ahmed et al.   Oncotarget

A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA

(2018) Daniel Little et al.   Scientific Reports

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

(2018) Soh Yamamoto et al.   Cell Reports

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

(2018) Xihang Chen et al.   Stem Cells International

Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease

(2018) Débora Masini et al.   Frontiers in Neurology

Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations

(2018) Hongyu Li et al.   Autophagy

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

(2018) Yuanyuan Fu et al.   Autophagy

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

(2018) Matheus Dyczynski et al.   CANCER LETTERS

TMEM41B is a novel regulator of autophagy and lipid mobilization

(2018) Francesca Moretti et al.   EMBO REPORTS

Genome-wide CRISPR screen identifiesTMEM41Bas a gene required for autophagosome formation

(2018) Keigo Morita et al.   JOURNAL OF CELL BIOLOGY

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

(2018) Mariachiara Buccarelli et al.   Cell Death & Disease

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

VPS34 complexes from a structural perspective

(2018) Yohei Ohashi et al.   JOURNAL OF LIPID RESEARCH

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

(2018) Jinjin Cai et al.   Cell Reports

Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease

(2018) Alexander B. Pupyshev et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics

(2017) Anna Chiara Nascimbeni et al.   FEBS Journal

S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse

(2017) Kun Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2.

(2017) Qiaohua Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia

(2017) Yuval Nash et al.   JOURNAL OF NEUROCHEMISTRY

Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner

(2017) Feng-Shu Hsieh et al.   Molecular Oncology

PLA2G16 represents a switch between entry and clearance of Picornaviridae

(2017) Jacqueline Staring et al.   NATURE

A toxic mutant huntingtin species is resistant to selective autophagy

(2017) Yuhua Fu et al.   Nature Chemical Biology

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Parkin-mediated mitophagy is downregulated in browning of white adipose tissue

(2017) David Taylor et al.   Obesity

SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

(2017) Fang Tang et al.   ONCOLOGY REPORTS

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

(2017) Sarah Jinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

(2017) Álvaro F Fernández et al.   Cell Death & Disease

Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

(2017) Hongrui Meng et al.   Nature Communications

Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells

(2017) Chia-Hao Chang et al.   Oncotarget

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

(2017) Chuan-Ying Xu et al.   Frontiers in Aging Neuroscience

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

(2017) Raja Ganesan et al.   PLoS Pathogens

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury

(2017) Fei-Juan Kong et al.   Scientific Reports

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autophagic homeostasis is required for the pluripotency of cancer stem cells

(2016) Tanveer Sharif et al.   Autophagy

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis

(2016) Hae-Youn Lee et al.   Autophagy

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway

(2016) Qin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of amyloid precursor protein processing by its KFERQ motif

(2016) Ji-Seon Park et al.   BMB Reports

Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgf /Smad Signaling

(2016) S. K. Yeo et al.   CANCER RESEARCH

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells

(2016) Kyota Aoyagi et al.   DIABETES

Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells

(2016) Young Hwan Kim et al.   FEBS LETTERS

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Thermogenic activation represses autophagy in brown adipose tissue

(2016) M Cairó et al.   INTERNATIONAL JOURNAL OF OBESITY

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

NBR1 enables autophagy-dependent focal adhesion turnover

(2016) Candia M. Kenific et al.   JOURNAL OF CELL BIOLOGY

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

(2016) Mitchell S. Wold et al.   Molecular Neurodegeneration

Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease

(2016) Kunie Ando et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

(2016) Nari Kim et al.   Nature Communications

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

(2016) Ying Liu et al.   Scientific Reports

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Genomics of Alzheimer Disease

(2016) Roger N. Rosenberg et al.   JAMA Neurology

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma

(2015) Brian A. Boone et al.   ANNALS OF SURGICAL ONCOLOGY

GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A

(2015) Ting-Ting Du et al.   Autophagy

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

(2015) Wen-Chuan Shen et al.   Autophagy

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice

(2015) Christian Baumeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

FOXA2 mRNA expression is associated with relapse in patients with Triple-Negative/Basal-like breast carcinoma

(2015) Ariadna Perez-Balaguer et al.   BREAST CANCER RESEARCH AND TREATMENT

Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer?

(2015) A. C. Yeh et al.   CANCER RESEARCH

Diabetes Susceptibility GenesPdx1andClec16aFunction in a Pathway Regulating Mitophagy in β-Cells

(2015) Scott A. Soleimanpour et al.   DIABETES

Antidiabetogenic effects of hydroxychloroquine on insulin sensitivity and beta cell function: a randomised trial

(2015) Mary Chester M. Wasko et al.   DIABETOLOGIA

F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy

(2015) Zhi Dong Zhou et al.   HUMAN MOLECULAR GENETICS

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

(2015) Patricia Martín-Maestro et al.   HUMAN MOLECULAR GENETICS

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

(2015) Xuan Ye et al.   HUMAN MOLECULAR GENETICS

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

Selective autophagy: Xenophagy

(2015) Kyle A. Bauckman et al.   METHODS

Autophagy in adipose tissue of patients with obesity and type 2 diabetes

(2015) J. Kosacka et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

(2015) Paola Maycotte et al.   MOLECULAR CANCER RESEARCH

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

(2015) Qing He et al.   MOLECULAR NEUROBIOLOGY

Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease

(2015) Karen E. Murphy et al.   MOVEMENT DISORDERS

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2015) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth

(2015) Jonathan Lévy et al.   NATURE CELL BIOLOGY

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

(2015) TAO HU et al.   ONCOLOGY REPORTS

Autophagy in Huntington disease and huntingtin in autophagy

(2015) Dale D.O. Martin et al.   TRENDS IN NEUROSCIENCES

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

(2015) M N Washington et al.   Cell Death & Disease

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

(2015) Shanshan He et al.   Nature Communications

HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

(2015) Linya Wang et al.   PLoS Pathogens

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

(2015) Wenxiao Jiang et al.   PLoS One

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

(2014) Anne-Maria Poehler et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells

(2014) Zhen Lu et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious

(2014) P. Maycotte et al.   CANCER RESEARCH

Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability

(2014) Rohann J.M. Correa et al.   CARCINOGENESIS

Regulation of autophagy by the Rab GTPase network

(2014) X Ao et al.   CELL DEATH AND DIFFERENTIATION

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

(2014) C L Buchheit et al.   CELL DEATH AND DIFFERENTIATION

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

Autophagy inhibition in early but not in later stages prevents 3T3-L1 differentiation: Effect on mitochondrial remodeling

(2014) Vojtech Skop et al.   DIFFERENTIATION

p62/SQSTM1 synergizes with autophagy for tumor growth in vivo

(2014) H. Wei et al.   GENES & DEVELOPMENT

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

(2014) Masaru Kurosawa et al.   HUMAN MOLECULAR GENETICS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway

(2014) Jia-Qing Yan et al.   MOLECULAR NEUROBIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP

(2014) E.E. Coffey et al.   NEUROSCIENCE

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

(2014) R. M. Ivatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causes and consequences of microsatellite instability in gastric carcinogenesis

(2014) Sérgia Velho   WORLD JOURNAL OF GASTROENTEROLOGY

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity

(2014) Xiaojuan Chen et al.   Protein & Cell

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

(2013) Chongben Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

(2013) Nan Chen et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

(2013) Congcong He et al.   CELL

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides

(2013) Meiju Äijälä et al.   Genes and Nutrition

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer

(2013) Hong Zhao et al.   MEDICAL ONCOLOGY

Transactivation of Atg4b by C/EBPβ Promotes Autophagy To Facilitate Adipogenesis

(2013) Liang Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

ER exit sites are physical and functional core autophagosome biogenesis components

(2013) Martin Graef et al.   MOLECULAR BIOLOGY OF THE CELL

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy

(2013) Victoria S Burchell et al.   NATURE NEUROSCIENCE

Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway

(2013) C-K Huang et al.   ONCOGENE

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Promoting Colonization in Metastatic HCC Cells by Modulation of Autophagy

(2013) Yuan-Fei Peng et al.   PLoS One

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer

(2012) Wei-Hua Zhou et al.   Autophagy

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer

(2012) Q. Lv et al.   CANCER RESEARCH

Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

(2012) Na Dong et al.   CELL

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection

(2012) Takashi Nozawa et al.   CELLULAR MICROBIOLOGY

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

(2012) Deepa Raju et al.   GASTROENTEROLOGY

Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy

(2012) Noriko Kondo-Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

(2012) Anne Grünewald et al.   NEUROBIOLOGY OF AGING

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease

(2011) Guanghua Wu et al.   BRAIN RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

(2011) R. Lazova et al.   CLINICAL CANCER RESEARCH

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

(2011) W. Quan et al.   DIABETOLOGIA

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

(2011) David Ramonet et al.   HUMAN MOLECULAR GENETICS

Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability

(2011) Chang Hyeok An et al.   HUMAN PATHOLOGY

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy

(2010) Gian Maria Fimia et al.   Autophagy

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

Specific Behavior of IntracellularStreptococcus pyogenesThat Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7

(2010) Atsuo Sakurai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas

(2010) Giuseppina Nicotra et al.   MODERN PATHOLOGY

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

(2010) Peter O Bauer et al.   NATURE BIOTECHNOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection

(2010) Carl Guévin et al.   VIROLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Targeted deletion ofautophagy-related 5(atg5) impairs adipogenesis in a cellular model and in mice

(2009) Rebecca Baerga et al.   Autophagy

Autophagy is involved in influenza A virus replication

(2009) Zhi Zhou et al.   Autophagy

Chloroquine Inhibits Colon Cancer Cell GrowthIn Vitroand Tumor GrowthIn Vivovia Induction of Apoptosis

(2009) Yuzhu Zheng et al.   CANCER INVESTIGATION

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Pdx1 and other factors that regulate pancreatic β-cell survival

(2009) K. Fujimoto et al.   DIABETES OBESITY & METABOLISM

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Autophagy regulates adipose mass and differentiation in mice

(2009) Rajat Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma

(2008) Z.-B. Ding et al.   CANCER RESEARCH

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

(2008) Min Sung Kim et al.   HUMAN PATHOLOGY

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

(2008) Zhen Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability

(2008) Mi Ran Kang et al.   JOURNAL OF PATHOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL