标题
Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 124, Issue 8, Pages 3634-3644
出版商
American Society for Clinical Investigation
发表日期
2014-07-18
DOI
10.1172/jci69866
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of -Synuclein Levels in -Cells
- (2013) P. Steneberg et al. DIABETES
- -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
- (2013) S. Costes et al. DIABETES
- Exendin-4 Improves β-Cell Function in Autophagy-Deficient β-Cells
- (2013) Hiroko Abe et al. ENDOCRINOLOGY
- The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
- (2013) Motoyuki Tamaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response
- (2012) Wenying Quan et al. ENDOCRINOLOGY
- p62/SQSTM1/A170: Physiology and pathology
- (2012) Masaaki Komatsu et al. PHARMACOLOGICAL RESEARCH
- Atomic View of a Toxic Amyloid Small Oligomer
- (2012) Arthur Laganowsky et al. SCIENCE
- Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability
- (2011) Caryn L. Heldt et al. BIOPHYSICAL JOURNAL
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway
- (2011) Ayako Fukunaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
- (2011) Eisuke Itakura et al. JOURNAL OF CELL BIOLOGY
- Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance
- (2011) Henry J Hiddinga et al. Journal of Diabetes Investigation
- Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions
- (2010) J F Rivera et al. CELL DEATH AND DIFFERENTIATION
- Conditional Gene Targeting in Mouse Pancreatic -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain
- (2010) B. Wicksteed et al. DIABETES
- Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
- (2010) S. Zraika et al. DIABETOLOGIA
- Autophagy protects against human islet amyloid polypeptide-associated apoptosis
- (2010) Shuhei Morita et al. Journal of Diabetes Investigation
- Evidence for Proteotoxicity in β Cells in Type 2 Diabetes
- (2009) Tatyana Gurlo et al. AMERICAN JOURNAL OF PATHOLOGY
- Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice
- (2009) Hong Su et al. DEVELOPMENTAL BIOLOGY
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
- (2008) Chie Ebato et al. Cell Metabolism
- Pancreatic β-cell mass in European subjects with type 2 diabetes
- (2008) J. Rahier et al. DIABETES OBESITY & METABOLISM
- Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis
- (2008) Leena Haataja et al. ENDOCRINE REVIEWS
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
- (2008) Judith Miklossy et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now