标题
α-synuclein impairs autophagosome maturation through abnormal actin stabilization
作者
关键词
Lysosomes, Mitochondria, Hyperexpression techniques, Neurons, Actins, Drosophila melanogaster, Parkinson disease, Genetically modified animals
出版物
PLoS Genetics
Volume 17, Issue 2, Pages e1009359
出版商
Public Library of Science (PLoS)
发表日期
2021-02-09
DOI
10.1371/journal.pgen.1009359
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
- (2019) Cheng-Wei Hsieh et al. Nature Communications
- The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
- (2019) Sara Bandres-Ciga et al. MOVEMENT DISORDERS
- Emerging links between pediatric lysosomal storage diseases and adult parkinsonism
- (2019) Daniel Ysselstein et al. MOVEMENT DISORDERS
- Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
- (2019) Farah H. Siddiqi et al. Nature Communications
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
- (2018) Sarah Pickles et al. CURRENT BIOLOGY
- Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria
- (2018) Antonina J. Kruppa et al. DEVELOPMENTAL CELL
- A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy
- (2018) Jie Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel ex vivo method for measuring whole brain metabolism in model systems
- (2018) Kathryn E. Neville et al. JOURNAL OF NEUROSCIENCE METHODS
- Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases
- (2018) Patrick Ejlerskov et al. NEUROBIOLOGY OF DISEASE
- α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
- (2018) Dalila G. Ordonez et al. NEURON
- Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
- (2018) Tom Cornelissen et al. eLife
- The Endolysosomal System and Proteostasis: From Development to Degeneration
- (2018) Bettina Winckler et al. JOURNAL OF NEUROSCIENCE
- Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
- (2018) Farah H. Bardai et al. PLOS BIOLOGY
- Rab2 promotes autophagic and endocytic lysosomal degradation
- (2017) Péter Lőrincz et al. JOURNAL OF CELL BIOLOGY
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Exploring Autophagy in Drosophila
- (2017) Péter Lőrincz et al. Cells
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome
- (2016) Junya Hasegawa et al. EMBO JOURNAL
- Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
- (2016) Dena G. Hernandez et al. JOURNAL OF NEUROCHEMISTRY
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myosins, Actin and Autophagy
- (2016) Antonina J. Kruppa et al. TRAFFIC
- Using Drosophila as an integrated model to study mild repetitive traumatic brain injury
- (2016) Ayeh Barekat et al. Scientific Reports
- shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity
- (2016) Susana A. Gonçalves et al. PLoS Genetics
- An antibody toolkit for the study of membrane traffic inDrosophila melanogaster
- (2016) Falko Riedel et al. Biology Open
- Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles
- (2016) Eric P. Ratliff et al. PLoS One
- WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism
- (2015) David J. Kast et al. CURRENT BIOLOGY
- BORC, a Multisubunit Complex that Regulates Lysosome Positioning
- (2015) Jing Pu et al. DEVELOPMENTAL CELL
- Endogenously Tagged Rab Proteins: A Resource to Study Membrane Trafficking in Drosophila
- (2015) Sebastian Dunst et al. DEVELOPMENTAL CELL
- Cellular functions of Rab GTPases at a glance
- (2015) Y. Zhen et al. JOURNAL OF CELL SCIENCE
- Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adultDrosophilaneurons
- (2015) Alessio Vagnoni et al. JOURNAL OF CELL SCIENCE
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- (2015) F.-L. Tang et al. JOURNAL OF NEUROSCIENCE
- CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane
- (2015) Na Mi et al. NATURE CELL BIOLOGY
- Improved and expanded Q-system reagents for genetic manipulations
- (2015) Olena Riabinina et al. NATURE METHODS
- Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
- (2014) M. W. Dodson et al. Disease Models & Mechanisms
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- The prevalence of Parkinson's disease: A systematic review and meta-analysis
- (2014) Tamara Pringsheim et al. MOVEMENT DISORDERS
- Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
- (2014) A. Beilina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine drives Drosophila sechellia adaptation to its toxic host
- (2014) Sofía Lavista-Llanos et al. eLife
- Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
- (2013) Maria Xilouri et al. BRAIN
- The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking
- (2013) Ye-Jin Chai et al. FEBS LETTERS
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates -Synuclein Toxicity in Neurons
- (2013) D. F. Tardiff et al. SCIENCE
- Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway
- (2012) Jochen Klucken et al. Autophagy
- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
- (2012) Youren Tong et al. Molecular Neurodegeneration
- Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
- (2012) Brian DuBoff et al. NEURON
- Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
- (2011) David C. Chan Annual Review of Genetics
- Parkinson's Disease: Genetics and Pathogenesis
- (2011) Joshua M. Shulman et al. Annual Review of Pathology-Mechanisms of Disease
- Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies
- (2011) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis
- (2010) Christopher J. Potter et al. CELL
- HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
- (2010) Joo-Yong Lee et al. EMBO JOURNAL
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
- (2009) Wai Haung Yu et al. AMERICAN JOURNAL OF PATHOLOGY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain
- (2008) Ioannis P. Nezis et al. JOURNAL OF CELL BIOLOGY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset
- (2008) W. C. Nichols et al. NEUROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation