Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

(2019) Pamela C. Rosato et al.   Nature Communications

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells

(2018) Wei Sun et al.   EXPERIMENTAL CELL RESEARCH

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese

(2018) Deng-Feng Zhang et al.   National Science Review

Tuning the ion selectivity of two-pore channels

(2017) Jiangtao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Golgi-Cox Staining Step by Step

(2016) Sami Zaqout et al.   Frontiers in Neuroanatomy

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

(2016) Kavya Reddy et al.   Cell Reports

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Two-pore channels at the intersection of endolysosomal membrane traffic

(2015) Jonathan S. Marchant et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release

(2015) Andrea L. Ambrosio et al.   MOLECULAR BIOLOGY OF THE CELL

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species

(2015) Haiqing Wang et al.   Cell and Bioscience

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

(2014) M. Ruas et al.   MOLECULAR AND CELLULAR BIOLOGY

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

(2014) W Qiu et al.   Cell Death & Disease

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1–42)

(2011) Fu-Qian He et al.   BRAIN RESEARCH

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke

(2011) Yun Chen et al.   MOLECULES

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

(2009) Antony Galione et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON