Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer

(2015) Natalia J. Sumi et al.   ACS Chemical Biology

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway

(2015) Ge Qin et al.   Oncotarget

Targeting AMPK for cancer prevention and treatment

(2015) Weidong Li et al.   Oncotarget

Knockdown of PPP5C Inhibits Growth of Hepatocellular Carcinoma Cells In Vitro

(2014) Liang Feng et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation

(2014) Rong Yu et al.   Cancer Cell International

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

(2014) Jidong Cheng et al.   PLoS One

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

Long-Term Outcome of the First 150 Liver Transplant Recipients: A Single-Center Experience

(2013) S.N. Sintra et al.   TRANSPLANTATION PROCEEDINGS

Trends in Liver Cancer Mortality Rates in Japan, USA, UK, France and Korea Based on the WHO Mortality Database

(2012) T. Matsuda et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

S100 Proteins Modulate Protein Phosphatase 5 Function

(2012) Fuminori Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk stratification for hepatitis B virus related hepatocellular carcinoma

(2012) Chih-Lin Lin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1)

(2011) G K Schwartz et al.   BRITISH JOURNAL OF CANCER

Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

(2011) Gottfried E. Konecny et al.   CLINICAL CANCER RESEARCH

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Specific expression of osteopontin and S100A6 in hepatocellular carcinoma

(2011) Zhan Hua et al.   SURGERY

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

(2010) Martin Voss et al.   CELLULAR SIGNALLING

The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 β cells

(2010) Luisa Garcia-Haro et al.   FASEB JOURNAL

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

(2010) Zhijun Luo et al.   Future Oncology

Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells

(2010) Dayana B. Rivadeneira et al.   GASTROENTEROLOGY

Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography/mass spectrometry

(2010) Leslie Nguyen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

(2010) J L Dean et al.   ONCOGENE

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Phosphatase 5 Regulates the Function of 53BP1 after Neocarzinostatin-induced DNA Damage

(2009) Yoonsung Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS