Article
Oncology
Marcin Michalak, Michel S. Lach, Sylwia Borska, Blazej Nowakowski, Kazuo Umezawa, Wiktoria M. Suchorska
Summary: Ovarian cancer is a lethal gynaecological malignancy with a reduced survival rate due to difficulty in early detection and chemoresistance. Activation of the NF-kappa B signalling pathway is associated with poor prognosis in patients. Developing inhibitors for this pathway has become a target in cancer therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Lichun Sun, Kaixin Wang, Lu Peng, Jinfang Zhang, Jie Yang, Juan Zhao, Jiang Xu, Jun Zheng, Yan Zeng
Summary: This study revealed that Naa10p plays a role in enhancing cisplatin sensitivity in oral squamous cell carcinoma (OSCC) and may serve as a potential target for chemotherapy in OSCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Roberto Campagna, Eleonora Salvolini, Veronica Pompei, Valentina Pozzi, Alessia Salvucci, Elisa Molinelli, Valerio Brisigotti, Davide Sartini, Anna Campanati, Annamaria Offidani, Monica Emanuelli
Summary: Melanoma, despite its small proportion of all skin tumors, is a major contributor to skin cancer-related deaths. This study identified NNMT enzyme as a potential therapeutic target for melanoma treatment, demonstrating that reducing NNMT levels can significantly inhibit cell proliferation and migration, as well as enhance sensitivity to chemotherapy drugs in melanoma cells.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Han Hong, Zhengkang Jin, Tao Qian, Xiaoyong Xu, Xiang Zhu, Qiang Fei, Jiamei Yang, Chengjun Sui, Minhui Xu
Summary: Falcarindiol (FAD) inhibits the proliferation and DNA repair of hepatocellular carcinoma (HCC) cells, promotes apoptosis, and enhances the chemosensitivity of cisplatin (DDP). FAD also exerts anti-tumor effects by dampening the STAT3/PTTG1 pathway in HCC cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Rongfeng Liu, Hongchen Li, Yanzhao Xu, Xing Li, Xiaojin Guo, Jian Shi, Yanzhi Cui, Zhiyu Wang, Junfeng Liu
Summary: TRIM59 is upregulated in esophageal cancer tissues and associated with poor survival and advanced TNM state; TRIM59 promotes esophageal cancer progression and motility by targeting p53 protein for degradation.
Article
Oncology
Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu, Qing Liu
Summary: CRNDE is a poor prognosis factor for GBM patients, upregulated in TMZ-resistant patients, and closely associated with chemotherapeutic response to TMZ treatment. Knockdown of CRNDE significantly reduces glioma cell viability and proliferation, enhances cell apoptosis, and improves sensitivity to TMZ treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Wei Zhu, Meiyuan Huang, Abhimanyu Thakur, Yuanliang Yan, Xiaoying Wu
Summary: This study found that FGF19 promotes cisplatin resistance in ovarian cancer cells by inducing autophagy. NGS analysis of 62 cases of high grade serous ovarian cancer identified a significantly amplified gene, FGF19. Furthermore, the expression level of FGF19 in ovarian cancer samples was higher than that in normal samples.
Article
Oncology
Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer, Virna D. Leaner
Summary: Pre-treatment with INI-43 significantly enhances cisplatin sensitivity in cervical cancer cells by stabilizing p53 and reducing nuclear import of NF kappa B. The combination of nuclear import inhibition and cisplatin shows synergistic effects in enhancing DNA damage and cell death in cervical cancer cells.
Article
Multidisciplinary Sciences
Yingying Wang, Minli Wei, Min Su, Zhiyuan Du, Jiaxi Dong, Yu Zhang, Yingdi Wu, Xiaopeng Li, Ling Su, Xiangguo Liu
Summary: DIRAS3, a candidate tumor suppressor protein, inhibits the migration of NSCLC cells by promoting the polyubiquitination and degradation of RAC1 through the interaction with RNF19B. The DIRAS3-RNF19B-RAC1 axis is associated with the malignant progression of NSCLC.
Article
Oncology
Shuai Peng, Jincheng Wang, Chang Lu, Zelin Xu, Jing-Jing Chai, Qing Ke, Xin-Zhou Deng
Summary: The study found that emodin can increase the sensitivity of non-small cell lung cancer cells to cisplatin by inhibiting Pgp expression. This suggests that emodin may be an effective adjuvant for cisplatin treatment.
Article
Oncology
Yang Zhou, Chunyan Wang, Jinye Ding, Yingying Chen, Yaoqi Sun, Zhongping Cheng
Summary: The study found that miR-133a expression was decreased in cisplatin-resistant ovarian cancer cells, and overexpression of miR-133a reduced cisplatin resistance. MiR-133a binds to the 3'UTR of YES1 and downregulates its expression. YES1 expression was upregulated in cisplatin-resistant ovarian cancer tissue, and miR-133a downregulated YES1 to inhibit cell autophagy and reduce cisplatin resistance.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Hongzhuang Wen, Changbao Qu, Zhu Wang, Haitao Gao, Wuyao Liu, Hu Wang, Hao Sun, Junfei Gu, Zhan Yang, Xiaolu Wang
Summary: Cuproptosis, induced by copper ions, is associated with the progression and drug resistance of various tumors. This study investigated the role of cuproptosis in the chemotherapeutic resistance of prostate cancer to docetaxel. The findings suggest that cuproptosis can promote cell death and enhance chemosensitivity to docetaxel through the inhibition of autophagy and promotion of G2/M phase retention via the mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
James Patrick Heiserman, Zenab Minhas, Elahe Nikpayam, Dong-Joo Cheon
Summary: Most ovarian cancer patients develop recurrent cancers which are often resistant to commonly employed chemotherapy agents, such as cisplatin. In this study, we investigated the role of heat shock protein 27 (HSP27) and fatty acid oxidation (FAO) in promoting cisplatin resistance. Our results showed that inhibiting HSP27 and FAO enhanced the cytotoxic effect of cisplatin and depleted cisplatin-induced ROS in cisplatin-resistant ovarian cancer cell lines. This dual inhibition strategy also increased cisplatin's cytotoxicity in in vivo xenograft tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Masahiro Hakariya, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Takanori Iwata, Nobuhiko Yui
Summary: Cancer cells respond to physical cues from the microenvironment by altering migration and chemosensitivity. The molecular mobility of polyrotaxane surfaces affects cellular spreading, migration, and chemosensitivity in lung, pancreatic, and breast cancer cells.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Verena Klingseisen, Julia Slanovc, Manuel Regouc, Andelko Hrzenjak
Summary: This study analyzed the influence of bisdemethoxycurcumin (BDMC) on non-small cell lung carcinoma (NSCLC) cells and found that BDMC had significant cytotoxic effects, especially on cisplatin-resistant cells. BDMC induced apoptosis and autophagy, inhibited cell cycle progression, and suppressed the growth and motility of cisplatin-resistant cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, Gee Young Suh
Summary: There have been changes in the care and outcome of mechanically ventilated patients in Korea, including improved pain and agitation control and active awakening attempts.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Rehabilitation
Jong Geol Do, Gee Young Suh, Yu Hui Won, Won Hyuk Chang, Stephanie Hiser, Dale M. Needham, Chi Ryang Chung
Summary: The study successfully translated and cross-culturally adapted the FSS-ICU into Korean and demonstrated excellent reliability, internal consistency, and construct validity for medical ICU patients in Korea.
DISABILITY AND REHABILITATION
(2022)
Review
Oncology
Gamze Bildik, Xiaowen Liang, Margie N. Sutton, Robert C. Bast, Zhen Lu
Summary: DIRAS3 is an imprinted tumor suppressor gene that blocks RAS function, inhibits malignant transformation and cancer cell growth, and facilitates the survival of dormant cancer cells. Downregulation of DIRAS3 expression is associated with various cancers and can serve as a target for novel therapy after conventional treatment.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Critical Care Medicine
Ryoung-Eun Ko, Danbee Kang, Hyejung Park, Juhee Cho, Gee Young Suh, Chi Ryang Chung
Summary: Objective delirium in the ICU may increase the risk of cognitive impairment and psychiatric problems post-discharge. Among ICU patients, those who experienced delirium during hospitalization had higher odds of developing cognitive impairment and psychiatric problems after discharge. Multiple cognitive impairment and psychiatric problems were commonly observed during the follow-up period.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Medicine, General & Internal
Subin Hwang, Danbee Kang, Hyejeong Park, Youngha Kim, Eliseo Guallar, Junseok Jeon, Jung-Eun Lee, Wooseong Huh, Gee-Young Suh, Juhee Cho, Hye-Ryoun Jang
Summary: The impact of renal replacement therapy (RRT) type and pre-existing kidney disease on outcomes in patients with acute kidney injury (AKI) has been investigated. The study found that the continuous RRT (CRRT) group had a higher risk of in-hospital mortality, while the dialysis group had a lower risk, especially in patients with pre-existing kidney disease. Both the dialysis and CRRT groups had a higher risk of end-stage kidney disease (ESKD) compared to the control group, with the CRRT group having an even higher risk in patients without pre-existing kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Geuk Young Jang, Chi Ryang Chung, Ryoung Eun Ko, Jin Young Lee, Tong In Oh, Gee Young Suh, Yongmin Kim, Eung Je Woo
Summary: The feasibility of simultaneous measurements of relative tidal volume (rTV) and relative stroke volume (rSV) using an electrical impedance tomography (EIT) device was tested in an animal study. The results showed that the EIT device could measure tidal volume and stroke volume in real time. However, further validation and broader applications are needed.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Kristin L. M. Boylan, Ashley Petersen, Timothy K. Starr, Xuan Pu, Melissa A. Geller, Robert C. Bast, Karen H. Lu, Ugo Cavallaro, Denise C. Connolly, Kevin M. Elias, Daniel W. Cramer, Tanja Pejovic, Amy P. N. Skubitz
Summary: This study aimed to develop a multiprotein classifier for detecting early stages of ovarian cancer by analyzing the levels of 92 cancer-related proteins in the blood. The combination of four proteins successfully detected over 90% of women with ovarian cancer and improved sensitivity and specificity compared to using CA125 alone. These findings suggest potential new biomarkers for early stage ovarian cancer detection.
Article
Cardiac & Cardiovascular Systems
Kyungsub Song, Soo Jin Na, Chi Ryang Chung, Kyeongman Jeon, Gee Young Suh, Suryeun Chung, Kiick Sung, Yang Hyun Cho
Summary: This study aimed to determine the optimal position of venovenous extracorporeal membrane oxygenation (V-V ECMO) draining cannulas for refractory respiratory failure based on short-term clinical results. The results showed that placing the V-V ECMO draining cannula in the right atrium (RA) instead of the inferior vena cava (IVC) is more effective for restricted fluid management and awake ECMO without significant recirculation, with similar arterial oxygenation, 90-day mortality, and clinical outcomes between the groups.
ANNALS OF THORACIC SURGERY
(2023)
Article
Critical Care Medicine
Ji Hwan Kim, Yong Kyun Kim, Dong Kyu Oh, Kyeongman Jeon, Ryoung-Eun Ko, Gee Young Suh, Sung Yun Lim, Yeon Joo Lee, Young-Jae Cho, Mi-Hyeon Park, Sang-Bum Hong, Chae-Man Lim, Sunghoon Park
Summary: This study investigated the significance of hypotension at sepsis recognition in sepsis patients with normal lactate levels. The results showed that neither hypotension nor vasopressor use adversely affected the hospital outcome in sepsis patients with normal lactate levels. The study emphasizes the importance of early interventions and appropriate use of antibiotics regardless of whether a patient is or is not hypotensive.
Article
Critical Care Medicine
Yun Im Lee, Ryoung-Eun Ko, Soo Jin Na, Jeong-Am Ryu, Yang Hyun Cho, Jeong Hoon Yang, Chi Ryang Chung, Gee Young Suh
Summary: In patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR), respiratory quotient (RQ) is not independently associated with poor neurological outcome. Instead, age, cardiopulmonary resuscitation to pump-on time, and lactate levels above 7.1 mmol/L are stronger predictors of poor neurological outcome.
ACUTE AND CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Hyung-Jun Kim, Dong Kyu Oh, Sung Yoon Lim, Young -Jae Cho, Sunghoon Park, Gee Young Suh, Chae-Man Lim, Yeon Joo Lee
Summary: The sensitivity of multidrug-resistant bacteria to antibiotics in sepsis patients in South Korea varies based on the location of infection onset. Long-term care hospitals and nursing homes are more likely to have multidrug-resistant gram-negative bacteria, while hospitals are more likely to have multidrug-resistant gram-positive bacteria.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Critical Care Medicine
Annette M. Esper, Yaseen M. Arabi, Maurizio Cecconi, Bin Du, Evangelos J. Giamarellos-Bourboulis, Nicole Juffermans, Flavia Machado, Sandra Peake, Jason Phua, Kathryn Rowan, Gee Young Suh, Greg S. Martin
Summary: Since the advent of critical care in the twentieth century, significant advancements have been made in diagnosing, supporting, and treating critically ill patients. However, further improvements are needed in areas such as physical ICU space, healthcare professionals, equipment and technology, information systems and data, and research systems to provide personalized, high-quality care and improve outcomes for critically ill patients and their families.
Article
Medicine, Research & Experimental
Zhen Lu, Weiqun Mao, Hailing Yang, Janice M. Santiago-O'Farrill, Philip J. Rask, Jayanta Mondal, Hu Chen, Cristina Ivan, Xiuping Liu, Chang-Gong Liu, Yuanxin Xi, Kenta Masuda, Eli M. Carrami, Meng Chen, Yitao Tang, Lan Pang, David S. Lakomy, George A. Calin, Han Liang, Ahmed A. Ahmed, Hariprasad Vankayalapati, Robert C. Bast
Summary: PARP inhibitors selectively target cancer cells with homologous recombination DNA repair deficiency, but resistance eventually develops. SIK2 inhibitors have been found to enhance the sensitivity of ovarian and triple-negative breast cancer cells to PARP inhibitors through suppressing DNA repair functions and gene transcription.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Jin Yeong Hong, Jae-Hoon Ko, Jinyoung Yang, Soyoung Ha, Eliel Nham, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Jin Yang Baek, You Min Sohn, Hyo Jung Park, Beomki Lee, Hee Jae Huh, Eun-Suk Kang, Gee Young Suh, Chi Ryang Chung, Kyong Ran Peck
Summary: This retrospective cohort study evaluated the effectiveness of tocilizumab in combination with dexamethasone for severe COVID-19. The study found that this combination therapy improved clinical recovery without increasing infectious complications or hindering the immune response.
YONSEI MEDICAL JOURNAL
(2022)
Article
Critical Care Medicine
Yunjoo Im, Danbee Kang, Ryoung-Eun Ko, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Soo Jin Na, Chi Ryang Chung, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim, Gee Young Suh
Summary: This study analyzed the relationship between time-to-antibiotics and in-hospital mortality in patients with sepsis. The results showed that timely administration of antibiotics improved outcomes in patients with septic shock, but the association between early antibiotic administration and outcome was not as clear in patients with sepsis without shock.