Article
Biochemistry & Molecular Biology
Nunzia D'Onofrio, Elisa Martino, Luigi Mele, Antonino Colloca, Martina Maione, Domenico Cautela, Domenico Castaldo, Maria Luisa Balestrieri
Summary: This study aimed to deepen current knowledge on the mechanism of delta VB-induced colon cancer cell death by investigating the apoptotic cascade in colorectal adenocarcinoma SW480 and SW620 cells and evaluating the molecular players of mitochondrial dysfunction. Results indicated that delta VB activated mitochondrial apoptosis through PINK1/Parkin pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yikai Zhang, Shengyao Wang, Xia Chen, Zhe Wang, Xinyi Wang, Qiao Zhou, Weihuan Fang, Chao Zheng
Summary: This study investigated the potential effects of liraglutide on preventing high glucose-induced endothelial dysfunction and excessive mitophagic response. The results showed that liraglutide protected endothelial cells from high glucose-induced damage by suppressing PINK1/Parkin-dependent mitophagy.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Bo Qian, Rong-Juan Jiang, Jia-Le Song, Chen-Qiang Wang
Summary: TDCPP-induced ferroptosis may be associated with its neurotoxicity, potentially through the PINK1/PARKIN-mediated mitophagy initiated by mitochondrial damage.
Review
Cell Biology
Xiusheng Chen, Qi Wang, Shihua Li, Xiao-Jiang Li, Weili Yang
Summary: PINK1 is a mitochondrial kinase involved in mitophagy and neuronal protection. Mutations in PINK1 gene can cause early onset Parkinson's disease with mitochondrial dysfunction. Although there is evidence from in vitro studies supporting the role of PINK1 in regulating mitochondrial function, strong in vivo evidence is still lacking. Additionally, PINK1 has functions independent of mitochondria.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaohui Zheng, Kun Liu, Qingqing Xie, Hangkuo Xin, Wei Chen, Shengyu Lin, Danqi Feng, Ting Zhu
Summary: This study demonstrated the essential role of PHB2 in PINK1/Parkin-mediated mitophagy in PrP106-126-treated neurons, as well as its neuroprotective effect against the neurotoxicity of the prion peptide. PHB2 was found to be involved in the accumulation of PINK1 and recruitment of Parkin to mitochondria, and its depletion worsened neuronal cell death induced by PrP106-126, while its overexpression alleviated PrP106-126 neuronal toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Vicente Roca-Agujetas, Cristina de Dios, Xenia Abadin, Anna Colell
Summary: Mitochondrial dysfunction in Alzheimer's disease is associated with impaired mitophagy due to accumulation of damaged mitochondria and high cholesterol levels. Cholesterol enrichment leads to disruption of mitophagy flux and cell aggregation of mitophagy adaptors, contributing to the progression of AD. Strategies focusing on restoring cholesterol homeostasis and mitochondrial redox balance may provide potential therapeutic options for AD.
Article
Cell Biology
Lianzhi Mao, Huahuan Liu, Rongjun Zhang, Yudi Deng, Yuting Hao, Wenzhen Liao, Miaomiao Yuan, Suxia Sun
Summary: Warangalone was found to induce mitochondrial damage and decrease cell viability in breast cancer cells by increasing ROS production. Additionally, it activated mitophagy through upregulation of PINK1 and Parkin, leading to mitochondrial apoptosis. However, the protective effect of autophagy/mitophagy against Warangalone-induced mitochondrial apoptosis was also observed. In conclusion, a combination of Warangalone and autophagy/mitophagy inhibitors may be a potential treatment for breast cancer.
Article
Oncology
Jing Zhang, Sili Chen, Ye Li, Weichun Xiao, Wei An
Summary: Both lfALR and sfALR protect mitochondria by promoting PINK1/Parkin-dependent mitophagy through FOXO3a activation, indicating a novel mechanism for mitochondrial protection.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Plant Sciences
Yanhong Cao, Xin Chen, Fuqiang Pan, Mingyang Wang, Haowen Zhuang, Jiangna Chen, Lu Lu, Lingjun Wang, Ting Wang
Summary: The Chinese herbal compound Xinmaikang (XMK) treats atherosclerosis (AS) by modulating macrophage mitophagy through the PINK1/Parkin signaling pathway. In vivo and in vitro experiments demonstrated that XMK reduces AS plaques, lipids, pro-inflammatory cytokines, and ROS levels, while promoting mitophagy. Knocking down PINK1 attenuated the effects of XMK on foam cell formation and PINK1/Parkin pathway activation.
Article
Food Science & Technology
Jiehuan Xu, Lingwei Sun, Mengqian He, Shushan Zhang, Jun Gao, Caifeng Wu, Defu Zhang, Jianjun Dai
Summary: This study demonstrates that resveratrol can counteract the toxic effects of zearalenone during porcine oocyte maturation. Resveratrol improves mitochondrial dysfunction and damage by enhancing PINK1/Parkin-mediated mitophagy, thereby promoting embryonic development.
Article
Cell Biology
Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda
Summary: Macroautophagy/autophagy is a complex intracellular degradation process with many regulatory factors. This study identified BCAS3 and C16orf70 as novel proteins associated with the autophagosome formation site and demonstrated their regulatory roles in autophagic activity. The BCAS3-C16orf70 complex affects the recruitment of core autophagy proteins to the phagophore assembly site.
Article
Biochemistry & Molecular Biology
Natsumi Miyazaki, Reika Shiratori, Taichi Oshima, Zhiheng Zhang, Robert Valencia, Joshua Kranrod, Liye Fang, John M. Seubert, Kousei Ito, Shigeki Aoki
Summary: Cancer cells rely on glycolysis to generate ATP for survival, but metabolic reprogramming involves mitophagy in mitochondrial activation, providing a potential strategy for cancer therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Plant Sciences
Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto
Summary: This study found that LIG improves mitochondrial function by promoting PINK1/Parkin-mediated mitophagy and alleviates neuronal injury in cerebral ischemia reperfusion injury.
Article
Environmental Sciences
Bangyan Hu, Jin Li, Daoyin Gong, Yuan Dai, Ping Wang, Lihong Wan, Shijun Xu
Summary: Chlorogenic acid (CGA) can prevent acetaminophen (APAP) hepatotoxicity by increasing PINK1-dependent mitophagy and inhibiting hepatocyte apoptosis.
Article
Neurosciences
Tingting Yan, Yan Zhao, Zhongyu Jiang, Jiyang Chen
Summary: This study investigated the role of mitophagy in cytotoxicity induced by acetaldehyde, a toxic metabolite of ethanol. The findings showed that acetaldehyde treatment induced mitophagy and cytotoxicity in SH-SY5Y cells. The overactive mitophagy and oxidative stress were identified as important mechanisms contributing to acetaldehyde-induced cytotoxicity. Autophagy inhibitors and an antioxidant could alleviate the cytotoxic effects.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Applied
Wei Xu, Xin Zhu, Di Zhao, Longjiang Zheng, Fengkai Shang, Zhiguo Zhang
Summary: This study presents a luminescence ratiometric thermometry technique that achieves high sensitivity and low measurement uncertainty by using a mixture of phosphors and optimizing the dopant concentration of rare earth ions, showing great potential in temperature measurement.
JOURNAL OF RARE EARTHS
(2022)
Article
Materials Science, Ceramics
Biao Zhang, Zhaoxin Zhong, Jiaqi Tang, Jian Ye, Feng Ye, Zhiguo Zhang, Qiang Liu
Summary: In this research, a series of three-dimensional architectures formed by SiC nanowires with different microstructures were fabricated to enhance the low-frequency wave absorption ability. The bamboo-shaped SiC nanowires in the felt increased the permittivity and conductivity loss and produced multiple scattering effects on the incident EM waves. The density of the SiC nanowire felt was as low as 0.022 g/cm3 due to the high porosity of 3D networks, fulfilling the requirements of lightweight and efficient electromagnetic wave absorption.
CERAMICS INTERNATIONAL
(2023)
Article
Optics
Meng Kou, Feng Qin, Xiyu Zhang, Yongda Wang, Hua Zhao, Zhiguo Zhang
Summary: This study investigated the effect of water on the properties of porphyrin derivatives, revealing that changes in fluorescence intensity are due to decreased intersystem crossing rate (k(ISC)) and increased non-fluorescence transition rate (k(nF)), impacted by vibrational energy levels and high-energy vibrations in aqueous solutions. The research not only provides insights into the behavior of porphyrin derivatives in photodynamic therapy, but also sheds light on the fluorescence lifetimes of porphyrin derivatives.
JOURNAL OF LUMINESCENCE
(2022)
Article
Optics
Wei Xu, Shuning Zong, Fengkai Shang, Longjiang Zheng, Zhiguo Zhang
Summary: This paper proposes a strategy to implement effective luminescence nanothermometry by utilizing the different thermal responses between Yb3+ -> Nd3+ and Nd3+ -> Yb3+ energy transfer processes. Unlike the traditional ratiometric sensing method, this technique uses intensity ratios between Yb3+ and Nd3+ near-IR emissions as the detecting and reference signals for temperature measurement, showing excellent immunity to interference and high thermal sensitivity.
PHOTONICS RESEARCH
(2022)
Article
Physics, Applied
Jiaming Li, Xudong Qi, Kai Li, Ming Lu, Zhaoliang Yu, Duo Wang, Shichong Xu, Enwei Sun, Zhiguo Zhang
Summary: A photoluminescence (PL) method is proposed to characterize the phase transition processes of Li+/Er3+:BaTiO3 (BLET) ferroelectric ceramics using infrared fluorescence intensities. The fluorescence intensities are used to detect the phase transition of BLET ceramics in multiple phase transition regions. The change in fluorescence intensities at the phase transition is attributed to a variation in the radiative transition probability of the I-4(13/2) level. By elucidating the relationship between fluorescence properties and the phase structure, our research contributes to a better understanding of the PL characteristics and phase structure of ferroelectric materials, and further enhances the application potential of PL methods in the detection of ferroelectric phase transition.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
Meng Kou, Feng Qin, Yongda Wang, Xiyu Zhang, Zheng Hu, Zhiguo Zhang
Summary: Environmental heavy atoms can enhance the room temperature phosphorescence emissions of Gd-HMME through the external heavy atom effect. In this study, a method is used to separate the external effect from the total effect and to define a quantity that describes the intrinsic nature of the external effect. The phosphorescent transition rate (kP) increases linearly with the environmental Gd3+ concentration, while the slope kappa is independent of Gd3+ concentration and only depends on the type of environmental heavy atoms.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Engineering, Multidisciplinary
Yongda Wang, Feng Qin, Honglin Zhang, Meng Kou, Zhiguo Zhang
Summary: A high-performance oxygen sensor is developed using room temperature phosphorescence. The sensor probe is made of Sol-gel matrix doped with Palladium (II) octaethylporphyrin (PdOEP) and has a sensitivity of 29.23 kPa(-1). The sensor incorporates a dual-channel structure to eliminate excitation source fluctuations and uses a photomultiplier tube equipped photon counter to enhance the signal-to-noise ratio. The detection limit of the system is 0.1 Pa with an indication error of +/- 1.5%.
Article
Optics
Lixin Peng, Changwen Wang, Leipeng Li, Feng Qin, Zhiguo Zhang
Summary: This study presents a ratiometric optical thermometry based on upconversion luminescence using different multi-photon processes. It proposes a new fluorescence intensity ratio thermometry that utilizes the ratio of specific emissions of Tm3+ and maintains anti-interference against excitation light fluctuations. The validity of the thermometry is confirmed through testing and analyzing emission spectra at different temperatures. The results demonstrate the feasibility and sensitivity of the ratiometric thermometry, providing guidance for selecting suitable upconversion luminescence materials for constructing anti-interference optical thermometers.
Article
Optics
Zhiyang Sun, Yongda Wang, Zhiguo Zhang
Summary: The study investigates the impact of port fraction on the radiant flux of an integrating cavity and establishes a theoretical model for light propagation in an arbitrary-shaped cavity. The relationship between port fraction, radiant flux, and diffuse reflectance is derived and experimentally validated in the absence of gas absorption. A method for measuring the diffuse reflectance of the integrating cavity is proposed, which effectively minimizes the influence of light source fluctuations on the measurement.
APPLIED PHYSICS B-LASERS AND OPTICS
(2023)
Article
Optics
Junqi Cui, Wei Xu, Miao Yao, Longjiang Zheng, Chunhai Hu, Zhiguo Zhang, Zhen Sun
Summary: A novel strategy using convolutional neural network for luminescence thermometry is proposed, which can autonomously select and extract multiple temperature-dependent features for regression temperature calculation, fully utilizing the temperature-dependent spectral data. Compared with traditional ratiometric technology and multiple linear regression method, the proposed method exhibits significantly higher accuracy, indicating the potential of deep learning in the field of luminescence thermometry.
JOURNAL OF LUMINESCENCE
(2023)
Article
Chemistry, Physical
Meng Kou, Feng Qin, Weiming Lu'', Zheng Hu, Zhiguo Zhang
Summary: Modern photodynamic therapy relies on the interaction between photosensitizer and oxygen to produce singlet oxygen. Energy transfer from the triplet excited state of photosensitizer to the excited state of oxygen is well-established, while the transfer from the singlet excited state is believed to be insignificant. However, our study provides evidence of energy transfer between the singlet excited state and oxygen in the production of singlet oxygen. This finding has been verified through fluorescence intensity measurements and ultrafast pump probe experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Mechanical
Ye Yuan, Bin Liu, Han Jia, Chi Zhang, Zhiguo Zhang, Suhao Wang, Yuzhen Yang, Xun Wang, Xiaobin Cheng, Zhaoli Yan, Jun Yang
Summary: This article introduces a nondestructive testing method based on honeycomb structure. By analyzing and experimental testing, it is found that there is a special wave propagation gap in the honeycomb structure, which can be used to detect debonding defects. This method detects and locates the debonding defects in the honeycomb structure with high sensitivity and efficiency, and it has great potential to be widely used in field tests.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Materials Science, Ceramics
Wei Xu, Fengze Bai, Longjiang Zheng, Chunhai Hu, Zhiguo Zhang, Yungang Zhang, Zhen Sun
Summary: By doping Ga3+ in garnet-structured phosphors, the upconversion luminescence can be significantly enhanced, leading to color switching in response to temperature change.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Meng Kou, Feng Qin, Yongda Wang, Xiyu Zhang, Zheng Hu, Hua Zhao, Zhiguo Zhang
Summary: In this study, a method was proposed to accurately determine the Stern-Volmer constant (K(SV)) of the photosensitizer by measuring the oxygen-dependent consumption of 1,3-diphenylisobenzofuran. The consumption time (Δ) was introduced as a measurable quantity and obtained from the absorption spectrum with a high signal-to-noise ratio. Experimentally, rose Bengal and metalloporphyrin were used to validate this method, and the K(SV) values obtained were 43(1) kPa(-1) and verified the accuracy of this method.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Xinyu Ai, Yungang Zhang, Zhiguo Zhang
Summary: High-sensitivity trace oxygen sensing based on far-ultraviolet absorption spectroscopy was achieved in this study. The optimal wavelength range for accurate and sensitive oxygen measurements was determined, and a calibration curve for oxygen was established. The detection sensitivity and lowest detection limit were also determined, indicating significant potential for application.