Article
Multidisciplinary Sciences
Morten Lundh, Ali Altintas, Marco Tozzi, Odile Fabre, Tao Ma, Farnaz Shamsi, Zachary Gerhart-Hines, Romain Barres, Yu-Hua Tseng, Brice Emanuelli
Summary: The scaffold protein Afadin is dynamically regulated by cold in brown adipose tissue (BAT) and plays a role in supporting the adrenergic response in brown adipocytes. Afadin depletion leads to decreased enrichment of gene sets controlling essential metabolic functions in BAT at thermoneutrality, and alters the reprogramming response to cold with enhanced enrichment of pathways related to metabolism and remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Xin Liu, Yuehua Zhu, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: This study provides a detailed landscape of miRNA expression in goat brown adipose tissue (BAT) and white adipose tissue (WAT). It is found that miR-433 acts as a negative regulator in controlling brown adipocyte differentiation and thermogenesis in goats.
Article
Endocrinology & Metabolism
Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, Shuqin Chen, Fan Hu, Jingyuan Ma, Yuejie Xu, Jun Xu, Xiaojing Ma, Ying Yang
Summary: This study investigates the regulation of survivin expression in mature adipocytes under various nutritional stimuli and the role of survivin in adipocyte function. The findings reveal that survivin expression is regulated by nutritional stress and plays a crucial role in maintaining normal brown adipose tissue mass, thermogenic program, and mitochondrial oxidative phosphorylation.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Madigan M. Snyder, Feng Yue, Lijia Zhang, Renjie Shang, Jiamin Qiu, Jingjuan Chen, Kun Ho Kim, Ying Peng, Stephanie N. Oprescu, Shawn S. Donkin, Pengpeng Bi, Shihuan Kuang
Summary: LETMD1 is essential for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. Mice lacking LETMD1 cannot maintain body temperature during cold exposure, highlighting the importance of LETMD1 in combating obesity.
Article
Multidisciplinary Sciences
Jong Han Lee, Ligen Lin, Xiangcang Ye, Christian Wolfrum, Yingjie Chen, Shaodong Guo, Yuxiang Sun
Summary: The study reveals that GHS-R has a cell-autonomous effect in brown adipocytes and regulates BAT thermogenic activity in a temperature- and metabolic state-dependent manner. The thermogenic effect of GHS-R in BAT is more pronounced in a cold environment and differentially variable based on metabolic state. Overall, GHS-R in BAT acts as a metabolic thermostat that differentially regulates thermogenesis in response to different metabolic and thermal stimuli.
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. These adaptations are driven by a lipogenic subpopulation of brown adipocytes located around Ucp1hi adipocytes, and are associated with the production of acylcarnitines.
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. This response is driven by a lipogenic subpopulation of brown adipocytes, which produce acylcarnitines to enhance the thermogenic response.
Article
Biochemistry & Molecular Biology
Yan Wang, Xingyue Chen, Wenli Fan, Xujia Zhang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: Oat beta-glucan is a common natural polysaccharide in oats with various health benefits, including antioxidant, anti-inflammatory, and immune-modulating effects. It can help regulate blood sugar and lipid levels, prevent cardiovascular diseases and diabetes, and promote intestinal health.
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Tao Zhu, Xu Chen, Shenglu Jiang
Summary: Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have been studied for their potential in improving obesity and metabolic disorders. However, the whitening of the brown fat graft and impaired metabolic function are significant challenges. This review discusses specific experiment designs, graft outcomes, and metabolic benefits, providing guidance for further investigation and innovation in BAT transplantation methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Yu -Shan Chang, Shun-Yun Hou, Shang-Shiuan Yu, Shin-Yu Tsai, Ying-Yi Chen, Li-Jin Hsu, Pei-Jane Tsai, Hui-Kuan Lin, Chyi-Her Lin, Yau-Sheng Tsai
Summary: The study found that postnatal short-term exposure to dexamethasone (Dex) impaired mitochondrial function and autophagy flux in brown adipose tissue (BAT) in neonatal rats. It was also found that preterm infants had higher diurnal temperature variation during systemic corticosteroid treatment.
Article
Endocrinology & Metabolism
Zijing Wang, Yunfeng Zhen, Yong Tang, Guangyao Song, Huijuan Ma, Hang Zhao
Summary: Maternal calorie restriction during pregnancy may affect the development and thermogenic capacity of brown adipose tissue in offspring, increasing the risk of adult obesity and metabolic disorders. This may be related to impaired fatty acid oxidation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Endocrinology & Metabolism
Nathalie Boulet, Ineke H. N. Luijten, Barbara Cannon, Jan Nedergaard
Summary: The study suggests that there is no clear correlation between the recruited state of BAT and WAT and macrophage accretion or attrition, making it less likely for macrophages to play a mediatory role in the recruitment process.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Aleix Gavalda-Navarro, Joan Villarroya, Ruben Cereijo, Marta Giralt, Francesc Villarroya
Summary: Brown adipose tissue (BAT) acts as an endocrine organ by secreting regulatory factors known as batokines, which exert effects on various tissues and organs including the liver, heart, and skeletal muscle. These batokines play a role in regulating insulin sensitivity, hepatic steatosis, glucose metabolism, and other physiological processes, and further research is needed to understand their impact on human metabolism.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
Cristina Garcia-Beltran, Ruben Cereijo, Cristina Plou, Aleix Gavalda-Navarro, Rita Malpique, Joan Villarroya, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez, Francesc Villarroya
Summary: This study reveals the relationship between brown adipose tissue (BAT) activity and adiposity measures and metabolic health in early infancy. The study found gender-specific differences in BAT activity and CXCL14 levels, which were negatively associated with adiposity measures in girls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Pere Domingo, Maria Gracia Mateo, Joan Villarroya, Ruben Cereijo, Ferran Torres, Joan C. Domingo, Laura Campderros, Jose M. Gallego-Escuredo, Maria del Mar Gutierrez, Isabel Mur, Noemi Corbacho, Francesc Vidal, Francesc Villarroya, Marta Giralt
Summary: People living with HIV, especially those on cART, have increased levels of GDF15, which are associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation. However, GDF15 is not correlated with cardiovascular risk after adjusting for age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Aleix Gavalda-Navarro, Serena Mirra, Yasmina Manso, David Sanchez-Infantes, Marta Giralt, Eduardo Soriano, Francesc Villarroya
Summary: ARMCX3 is identified as a novel player in regulating the plasticity of thermogenic adipose tissue, acting to repress the acquisition of the browning phenotype and demonstrating a direct association with obesity indicators in mice and humans.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pediatrics
Marta Diaz, Gemma Carreras-Badosa, Joan Villarroya, Aleix Gavalda-Navarro, Judit Bassols, Francis de Zegher, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: Circulating GDF15 concentrations significantly increase in LBW/catch-up girls after long-term metformin treatment, and are negatively associated with insulin, androgens, body fat, and visceral fat. Prepubertal intervention with metformin reduces central adiposity and insulin resistance.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Pere Domingo, Tania Quesada-Lopez, Joan Villarroya, Montserrat Cairo, Maria Del Mar Gutierrez, Maria Gracia Mateo, Isabel Mur, Noemi Corbacho, Joan Carles Domingo, Francesc Villarroya, Marta Giralt
Summary: The study suggests that INsTIs have no significant effect on human adipose cell differentiation, but exert distinct effects on gene expression and secretion of adipokines and cytokines.
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Delgado-Angles, Albert Blasco-Roset, Francisco J. Godoy-Nieto, Montserrat Cairo, Francesc Villarroya, Marta Giralt, Joan Villarroya
Summary: Loss of Parkin gene prevents adipose accretion and improves systemic metabolism in aged mice. It maintains browning in subcutaneous adipose tissue and reduces age-associated induction of inflammation. However, Parkin gene invalidation has a lesser effect on brown adipose tissue in aged mice.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Andrea Soria-Gondek, Pablo Fernandez-Garcia, Lorena Gonzalez, Marjorie Reyes-Farias, Marta Murillo, Aina Valls, Nativitat Real, Silvia Pellitero, Jordi Tarasco, Benjamin Jenkins, Maria Galan, Francesc Villarroya, Albert Koulman, Patricia Corrales, Antonio Vidal-Puig, Ruben Cereijo, David Sanchez-Infantes
Summary: The objective of this study was to assess the circulating lipidome of children and adults with obesity before and after clinical interventions. The findings showed that certain lipid species increased in abundance in both children and adults, while others decreased. There was a specific set of lipid species that were regulated after clinical interventions in both age groups, suggesting a core circulating lipid profile indicative of obesity development and improvement.