Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

(2013) Congcong He et al.   CELL

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl

(2013) D. Mokhtari et al.   DIABETOLOGIA

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Autophagy Deficiency by Hepatic FIP200 Deletion Uncouples Steatosis From Liver Injury in NAFLD

(2013) Di Ma et al.   MOLECULAR ENDOCRINOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

(2011) W. Quan et al.   DIABETOLOGIA

C-Kit controls IL-1β-induced effector functions in HMC-cells

(2011) Sebastian Drube et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

(2011) Myoung Sook Han et al.   JOURNAL OF LIPID RESEARCH

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

(2011) S. Z. Imam et al.   JOURNAL OF NEUROSCIENCE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

(2010) Masahiro Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)

(2010) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice

(2009) M. S. Han et al.   DIABETES

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

(2009) Cristian Bellodi et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mantle skewness and ridge segmentation

(2009) Satish C. Singh et al.   NATURE

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

(2009) P. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive proteomics analysis of autophagy-deficient mouse liver

(2008) Naomi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE