标题
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
作者
关键词
Antimitotics, Tubulin, Taxanes, Paclitaxel, Docetaxel, Mechanisms of action, Resistance to taxanes, Surmounting drug resistance, ABC transporters
出版物
DRUG RESISTANCE UPDATES
Volume 54, Issue -, Pages 100742
出版商
Elsevier BV
发表日期
2021-01-12
DOI
10.1016/j.drup.2020.100742
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The microtubule targeting agents eribulin and paclitaxel activate similar signaling pathways and induce cell death predominantly in a caspase-independent manner
- (2020) Lisa C. Hüsemann et al. CELL CYCLE
- Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update
- (2020) Jinyun Dong et al. DRUG RESISTANCE UPDATES
- Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications
- (2020) Francis Boateng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms
- (2020) Mark Borris D. Aldonza et al. Science Advances
- Microtubule engagement with taxane is altered in taxane-resistant gastric cancer
- (2020) Giuseppe Galletti et al. CLINICAL CANCER RESEARCH
- Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors
- (2020) Florence Atrafi et al. CLINICAL CANCER RESEARCH
- Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors
- (2020) Sabrina Dallavalle et al. DRUG RESISTANCE UPDATES
- Nanomedicine to target multidrug resistant tumors
- (2020) Elise Lepeltier et al. DRUG RESISTANCE UPDATES
- Taxane resistance in prostate cancer is mediated by decreased drug-target engagement
- (2020) Ada Gjyrezi et al. JOURNAL OF CLINICAL INVESTIGATION
- Improved melanoma suppression with target-delivered TRAIL and PaclitaxSel by a multifunctional nanocarrier
- (2020) Shiqi Huang et al. JOURNAL OF CONTROLLED RELEASE
- Two-Phase Synthesis of Taxol
- (2020) Yuzuru Kanda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Noncoding RNAs in gastric cancer: implications for drug resistance
- (2020) Ling Wei et al. Molecular Cancer
- Folic Acid-Modified Nanoerythrocyte for Codelivery of Paclitaxel and Tariquidar to Overcome Breast Cancer Multidrug Resistance
- (2020) Ping Zhong et al. MOLECULAR PHARMACEUTICS
- Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20
- (2020) Katherine V. Richeson et al. Nature Chemical Biology
- Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment
- (2020) Angela Flavia Serpico et al. Cell Death & Disease
- The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis
- (2020) Patricia Ferreira et al. Oncotarget
- Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target
- (2020) Theo Battista et al. Cancers
- The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane
- (2020) Michal Stark et al. Cells
- Exosomes as drug delivery vehicle and contributor of resistance to anticancer drugs
- (2020) Mahendran Chinnappan et al. CANCER LETTERS
- Two-Phase Total Synthesis of Taxanes: Tactics and Strategies
- (2020) Yuzuru Kanda et al. JOURNAL OF ORGANIC CHEMISTRY
- Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer
- (2020) Genevieve Deblois et al. Cancer Discovery
- DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons
- (2020) Therese Wilhelm et al. Genes
- Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein
- (2020) Christina A. Le et al. IUCrJ
- Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer
- (2020) Elizabeth Varghese et al. Cancers
- A phase I dose-escalation and pharmacokinetic study of a micellar nanoparticle with entrapped docetaxel (CPC634) in patients with advanced solid tumours
- (2020) Florence Atrafi et al. JOURNAL OF CONTROLLED RELEASE
- Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
- (2020) Nuray Erin et al. DRUG RESISTANCE UPDATES
- Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells
- (2019) Xiaofu Qiu et al. BMC CANCER
- Septin filament coalignment with microtubules depends on SEPT9_i1 and tubulin polyglutamylation, and is an early feature of acquired cell resistance to paclitaxel
- (2019) Benjamin Targa et al. Cell Death & Disease
- The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or WZB-117 Inhibit the Viability of Highly Resistant Human Lung Cancer Cells
- (2019) Juan Sebastian Yakisich et al. Stem Cells International
- Structural insight into substrate and inhibitor discrimination by human P-glycoprotein
- (2019) Amer Alam et al. SCIENCE
- The multiple mechanisms that regulate p53 activity and cell fate
- (2019) Antonina Hafner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Potential of Combining Tubulin-Targeting Anticancer Therapeutics and Immune Therapy
- (2019) Alexis Fong et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer
- (2019) Shweta Shyam Prassanawar et al. BIOCHEMICAL JOURNAL
- EZH2 Confers Sensitivity of Breast Cancer Cells to Taxol by Attenuating p21 Expression Epigenetically
- (2019) Xin Mu et al. DNA AND CELL BIOLOGY
- HIF inactivation of p53 in Ovarian Cancer Can be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity
- (2019) Basmina Parmakhtiar et al. MOLECULAR CANCER RESEARCH
- Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
- (2019) Reza Dastvan et al. SCIENCE
- FoxM1 Induced Paclitaxel Resistance via Activation of FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of ABCA2 Transporter
- (2019) Chao Huang et al. Molecular Therapy-Oncolytics
- Increase Paclitaxel Sensitivity to Better Suppress Serous Epithelial Ovarian Cancer via Ablating Androgen Receptor/Aryl Hydrocarbon Receptor-ABCG2 Axis
- (2019) Wei-Min Chung et al. Cancers
- Developing Body-Components-Based Theranostic Nanoparticles for Targeting Ovarian Cancer
- (2019) Ravit Edelman et al. Pharmaceutics
- The emerging role of noncoding RNAs in colorectal cancer chemoresistance
- (2019) Ling Wei et al. CELLULAR ONCOLOGY
- What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg
- (2019) Teodora Alexa-Stratulat et al. DRUG RESISTANCE UPDATES
- The multi-factorial nature of clinical multidrug resistance in cancer
- (2019) Yehuda G. Assaraf et al. DRUG RESISTANCE UPDATES
- Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
- (2019) Abhilash D Pandya et al. International Journal of Nanomedicine
- Cancer stem cell (a)symmetry & plasticity: Tumorigenesis and therapy relevance
- (2019) Masoud Najafi et al. LIFE SCIENCES
- Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo
- (2019) Shira Engelberg et al. Cell Death & Disease
- Pre-treatment with the CDK4/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells
- (2019) Daniele Cretella et al. Scientific Reports
- Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin
- (2019) Hao Lin et al. BIOCHEMICAL PHARMACOLOGY
- Towards the overcoming of anticancer drug resistance mediated by p53 mutations
- (2019) Xin Cao et al. DRUG RESISTANCE UPDATES
- Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance
- (2019) M. Helena Vasconcelos et al. DRUG RESISTANCE UPDATES
- Extracellular vesicles and anti-Cancer drug resistance
- (2018) Niamh Mc Namee et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs
- (2018) Aleksandar Radakovic et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8
- (2018) Rochanawan Sootichote et al. BMC CANCER
- Impact of Drug Metabolism/Pharmacokinetics and Their Relevance upon Taxus-based Drug Development
- (2018) Da-Cheng Hao et al. CURRENT DRUG METABOLISM
- How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
- (2018) Philippe Icard et al. DRUG RESISTANCE UPDATES
- How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
- (2018) Thorsten Stiewe et al. DRUG RESISTANCE UPDATES
- Redundant angiogenic signaling and tumor drug resistance
- (2018) Rajesh N. Gacche et al. DRUG RESISTANCE UPDATES
- Antileukemic effect of paclitaxel in combination with metformin in HL-60 cell line
- (2018) Aycan Asik et al. GENE
- Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery
- (2018) Iwao Ojima et al. JOURNAL OF NATURAL PRODUCTS
- Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations
- (2018) Myung Soo Kim et al. Nanomedicine-Nanotechnology Biology and Medicine
- Determinants and clinical implications of chromosomal instability in cancer
- (2018) Laurent Sansregret et al. Nature Reviews Clinical Oncology
- Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo
- (2018) Aditya Parekh et al. ONCOGENE
- Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
- (2018) Amer Alam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia and Noncoding RNAs in Taxane Resistance
- (2018) Perla Pucci et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
- (2018) Dongshao Chen et al. Cell Death & Disease
- Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
- (2018) Youli Cai et al. Cell Death & Disease
- Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response
- (2018) Xiaobin Zheng et al. Oncotarget
- Cancer cell-selective, clathrin-mediated endocytosis of aptamerdecorated nanoparticles
- (2018) Shira Engelberg et al. Oncotarget
- Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance
- (2018) Ziqian Li et al. Cancer Research and Treatment
- Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer
- (2018) Karen A. Autio et al. JAMA Oncology
- Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies
- (2018) Brandon Bumbaca et al. Acta Pharmaceutica Sinica B
- Current taxane formulations and emerging cabazitaxel delivery systems
- (2018) Boyang Sun et al. Nano Research
- Nuclear envelope assembly defects link mitotic errors to chromothripsis
- (2018) Shiwei Liu et al. NATURE
- Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol
- (2018) Faezeh Asghari et al. Advances in Clinical and Experimental Medicine
- Mutant p53 as a guardian of the cancer cell
- (2018) Fiamma Mantovani et al. CELL DEATH AND DIFFERENTIATION
- Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance
- (2018) Piyush B. Gupta et al. Cell Stem Cell
- Modulating ROS to overcome multidrug resistance in cancer
- (2018) Qingbin Cui et al. DRUG RESISTANCE UPDATES
- Phase 1 trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer
- (2018) Amit Mahipal et al. INVESTIGATIONAL NEW DRUGS
- Site occupancy calibration of taxane pharmacology in live cells and tissues
- (2018) Javier J. Pineda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
- (2018) Benny Zhitomirsky et al. Cell Death & Disease
- Reversing multi-drug tumor resistance to Paclitaxel by well-defined pH-sensitive amphiphilic polypeptide block copolymers via induction of lysosomal membrane permeabilization
- (2018) Hassan Mostoufi et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Tubulin Post-Translational Modifications and Microtubule Dynamics
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration
- (2017) Jessica Field et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Taxol®: The First Microtubule Stabilizing Agent
- (2017) Chia-Ping Yang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Paclitaxel: What has been done and the challenges remain ahead
- (2017) Ezequiel Bernabeu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria
- (2017) Allimuthu T. Dharmaraja JOURNAL OF MEDICINAL CHEMISTRY
- Tubulin isoform composition tunes microtubule dynamics
- (2017) Annapurna Vemu et al. MOLECULAR BIOLOGY OF THE CELL
- Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
- (2017) Brandy Verhalen et al. NATURE
- Tubulin acetylation protects long-lived microtubules against mechanical ageing
- (2017) Didier Portran et al. NATURE CELL BIOLOGY
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
- (2017) Zhenjie Xu et al. SCIENCE
- Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma
- (2017) Kelly Gaudelot et al. TUMOR BIOLOGY
- Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells
- (2017) Ilaria Genovese et al. Cell Death & Disease
- The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells
- (2017) Youxiang Hou et al. Cell Death & Disease
- Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells
- (2017) Yingchun Qu et al. Oncology Letters
- Analysis of resistance-associated gene expression in docetaxel-resistant prostate cancer cells
- (2017) Sangchul Lee et al. Oncology Letters
- Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel
- (2017) Cody W. Lewis et al. Oncotarget
- Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
- (2017) Radosław Januchowski et al. Oncotarget
- Phosphatidylinositol 3-kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells
- (2017) Floriana Morgillo et al. Oncotarget
- MicroRNA-128 suppresses paclitaxel-resistant lung cancer by inhibiting MUC1-C and BMI-1 in cancer stem cells
- (2017) Hyebin Koh et al. Oncotarget
- Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
- (2017) Benny Zhitomirsky et al. Oncotarget
- Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?
- (2017) T. J. Mitchison et al. Open Biology
- Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance
- (2017) Duncan Ayers et al. Genes
- Tesetaxel, a novel oral taxane, as second-line therapy for advanced gastroesophageal cancer: Activity in a dose-ranging study.
- (2017) Jaffer A. Ajani et al. JOURNAL OF CLINICAL ONCOLOGY
- Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function
- (2017) I. Kalhari Lindamulage et al. Scientific Reports
- Mechanisms of Primary and Secondary Resistance to Imatinib in Chronic Myeloid Leukemia
- (2017) Alfonso Quintás-Cardama et al. Cancer Control
- Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
- (2016) Anju Singh et al. ACS Chemical Biology
- Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel
- (2016) Sayaka Sobue et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer
- (2016) W. Wang et al. BIOSCIENCE REPORTS
- The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells
- (2016) Stine Ninel Hansen et al. BMC GENOMICS
- Hallmarks of cancer stem cell metabolism
- (2016) Patricia Sancho et al. BRITISH JOURNAL OF CANCER
- The complexity of integrins in cancer and new scopes for therapeutic targeting
- (2016) Hellyeh Hamidi et al. BRITISH JOURNAL OF CANCER
- Microtubule destabilising agents: far more than just antimitotic anticancer drugs
- (2016) Darcy Bates et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies
- (2016) H.-S. Lee et al. CANCER RESEARCH
- Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors
- (2016) D. D. Von Hoff et al. CLINICAL CANCER RESEARCH
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics
- (2016) Ruud H. Wijdeven et al. DRUG RESISTANCE UPDATES
- ABC transporters as mediators of drug resistance and contributors to cancer cell biology
- (2016) Jamie I. Fletcher et al. DRUG RESISTANCE UPDATES
- Lysosomes as mediators of drug resistance in cancer
- (2016) Benny Zhitomirsky et al. DRUG RESISTANCE UPDATES
- Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
- (2016) Wen Li et al. DRUG RESISTANCE UPDATES
- Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility
- (2016) Richard J McKenney et al. EMBO JOURNAL
- ATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview
- (2016) Elena Arrigoni et al. Expert Opinion on Drug Metabolism & Toxicology
- Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity
- (2016) Lothar Esser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The reversal of multidrug resistance in ovarian carcinoma cells by co-application of tariquidar and paclitaxel in transferrin-targeted polymeric micelles
- (2016) Wanting Zou et al. JOURNAL OF DRUG TARGETING
- Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
- (2016) Roberta Visconti et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer-associated fibroblasts mediated chemoresistance by a FOXO1/TGFβ1 signaling loop in esophageal squamous cell carcinoma
- (2016) Hongfang Zhang et al. MOLECULAR CARCINOGENESIS
- Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer
- (2016) Bowen Du et al. MOLECULES
- Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
- (2016) Myung Soo Kim et al. Nanomedicine-Nanotechnology Biology and Medicine
- The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
- (2016) Małgorzata Nita et al. Oxidative Medicine and Cellular Longevity
- 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes
- (2016) Chia-Ping Huang Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters
- (2016) Vlasta Němcová-Fürstová et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- Improving Taxane-Based Chemotherapy in Castration-Resistant Prostate Cancer
- (2016) Jan Kroon et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- High levels of class III β-tubulin expression are associated with aggressive tumor features in breast cancer
- (2016) PATRICK LEBOK et al. Oncology Letters
- Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia
- (2016) Jhih-Pu Syu et al. Oncotarget
- Multidrug Resistance Proteins (MRPs) and Cancer Therapy
- (2015) Yun-Kai Zhang et al. AAPS Journal
- Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer
- (2015) Jintong Du et al. BMC CANCER
- Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules
- (2015) Yu Yu et al. CANCER CELL
- Treatment regimens of classical and newer taxanes
- (2015) Markus Joerger CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma
- (2015) Tommaso Azzarito et al. CANCER LETTERS
- FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition
- (2015) Zhijiao Zhou et al. CANCER LETTERS
- Elucidating the Mechanism of Action of the Clinically Approved Taxanes: A Comprehensive Comparison of Local and Allosteric Effects
- (2015) Cassandra D. M. Churchill et al. Chemical Biology & Drug Design
- Notch Pathway Inhibition Using PF-03084014, a -Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer
- (2015) D. Cui et al. CLINICAL CANCER RESEARCH
- Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach
- (2015) Sophie Taylor et al. DRUG RESISTANCE UPDATES
- The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade
- (2015) Rishil J. Kathawala et al. DRUG RESISTANCE UPDATES
- ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
- (2015) S. Meidhof et al. EMBO Molecular Medicine
- Targeting the Androgen Receptor Confers In Vivo Cross-resistance Between Enzalutamide and Docetaxel, But Not Cabazitaxel, in Castration-resistant Prostate Cancer
- (2015) Robert J. van Soest et al. EUROPEAN UROLOGY
- Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model
- (2015) Jeroen J.M.A. Hendrikx et al. INTERNATIONAL JOURNAL OF CANCER
- Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy
- (2015) Kishore B. Challagundla et al. JNCI-Journal of the National Cancer Institute
- Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway
- (2015) Cuixia Yang et al. MEDICAL ONCOLOGY
- Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer
- (2015) M. Talekar et al. MOLECULAR CANCER THERAPEUTICS
- Whole–genome characterization of chemoresistant ovarian cancer
- (2015) Ann-Marie Patch et al. NATURE
- Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
- (2015) Hossein Borghaei et al. NEW ENGLAND JOURNAL OF MEDICINE
- Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance
- (2015) P Khongkow et al. ONCOGENE
- Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
- (2015) Renata Silva et al. PHARMACOLOGY & THERAPEUTICS
- Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
- (2015) Haiquan Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of SPARC expression in pancreatic cancer progression and patient survival
- (2015) Chinmay Gundewar et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells
- (2015) N Mohell et al. Cell Death & Disease
- IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
- (2015) Zhen Ning Wee et al. Nature Communications
- MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs
- (2015) Yang Zhao et al. Drug Design Development and Therapy
- Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma
- (2015) Inik Chang et al. Oncotarget
- Structural basis of Sorcin-mediated calcium-dependent signal transduction
- (2015) Andrea Ilari et al. Scientific Reports
- TaxKB: a knowledge base for new taxane-related drug discovery
- (2015) Kasi Murugan et al. BioData Mining
- Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
- (2015) Nirmala Chandralega Kampan et al. Biomed Research International
- Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy
- (2015) Kishore B. Challagundla et al. JNCI-Journal of the National Cancer Institute
- Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein
- (2015) Paul Szewczyk et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway
- (2015) WEIPENG ZHANG et al. Molecular Medicine Reports
- Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5
- (2015) Prisca Exertier et al. Oncotarget
- βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer
- (2015) Joshua A. McCarroll et al. Oncotarget
- Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
- (2015) Benny Zhitomirsky et al. Oncotarget
- Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
- (2014) Qingcheng Mao et al. AAPS Journal
- The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent
- (2014) David G. I. Kingston et al. ACCOUNTS OF CHEMICAL RESEARCH
- Reversing Effect of Sorcin in the Drug Resistance of Human Nasopharyngeal Carcinoma
- (2014) Xuebing Liu et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- The multifaceted regulation and functions of PKM2 in tumor progression
- (2014) Zongwei Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
- (2014) Radosław Januchowski et al. BIOMEDICINE & PHARMACOTHERAPY
- Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances
- (2014) Ruth Matesanz et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy
- (2014) Carola H. Ries et al. CANCER CELL
- High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
- (2014) Gregory M. Alushin et al. CELL
- Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells
- (2014) J Bargiela-Iparraguirre et al. CELL CYCLE
- Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
- (2014) J. E. Abraham et al. CLINICAL CANCER RESEARCH
- Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon
- (2014) C. Rocha et al. EMBO JOURNAL
- Dual Inhibition of Phosphatidylinositol 3′-Kinase and Mammalian Target of Rapamycin Using NVP-BEZ235 as a Novel Therapeutic Approach for Mucinous Adenocarcinoma of the Ovary
- (2014) Akiko Kudoh et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer
- (2014) VIVIANA CASTILLO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
- (2014) YOUNG-AH SUH et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The tubulin code: Molecular components, readout mechanisms, and functions
- (2014) Carsten Janke JOURNAL OF CELL BIOLOGY
- 3-Methyladenine can depress drug efflux transporters via blocking the PI3K–AKT–mTOR pathway thus sensitizing MDR cancer to chemotherapy
- (2014) Zhenyou Zou et al. JOURNAL OF DRUG TARGETING
- NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells
- (2014) Cheng Liu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Mechanisms of Resistance to Cabazitaxel
- (2014) G. E. Duran et al. MOLECULAR CANCER THERAPEUTICS
- Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
- (2014) M. Marin-Aguilera et al. MOLECULAR CANCER THERAPEUTICS
- Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
- (2014) Cristina C. Rohena et al. NATURAL PRODUCT REPORTS
- Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C
- (2014) Katharine L. Sackton et al. NATURE
- Regulation of microtubule motors by tubulin isotypes and post-translational modifications
- (2014) Minhajuddin Sirajuddin et al. NATURE CELL BIOLOGY
- Sorcin Links Calcium Signaling to Vesicle Trafficking, Regulates Polo-Like Kinase 1 and Is Necessary for Mitosis
- (2014) Vasiliki S. Lalioti et al. PLoS One
- Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells
- (2014) Prathap Kumar S. Mahalingaiah et al. PLoS One
- A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth
- (2014) Liwei Lang et al. PLoS One
- Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
- (2014) Debangshu Samanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles
- (2014) L. M. Zasadil et al. Science Translational Medicine
- Extracellular vesicles: emerging targets for cancer therapy
- (2014) Pieter Vader et al. TRENDS IN MOLECULAR MEDICINE
- Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein
- (2014) Meng-meng Lv et al. TUMOR BIOLOGY
- Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling
- (2014) X Peng et al. Cell Death & Disease
- Regulation and Role of EZH2 in Cancer
- (2014) Hirohito Yamaguchi et al. Cancer Research and Treatment
- Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
- (2014) Hira Lal Goel et al. Cell Reports
- Drug Resistance in Cancer: An Overview
- (2014) Genevieve Housman et al. Cancers
- Microtubules and Their Role in Cellular Stress in Cancer
- (2014) Amelia L. Parker et al. Frontiers in Oncology
- Rationally designed nanovehicles to overcome cancer chemoresistance
- (2013) Yoav D. Livney et al. ADVANCED DRUG DELIVERY REVIEWS
- The pharmacological bases of the antiangiogenic activity of paclitaxel
- (2013) Guido Bocci et al. ANGIOGENESIS
- Clinical and economic implications of the use of nanoparticle paclitaxel (Nanoxel) in India
- (2013) A. A. Ranade et al. ANNALS OF ONCOLOGY
- Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines
- (2013) Radosław Januchowski et al. BIOMEDICINE & PHARMACOTHERAPY
- Identification and analysis of CD133+ melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response
- (2013) Abdelouahid El-Khattouti et al. CANCER LETTERS
- Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy
- (2013) Serena Giovinazzi et al. CELL CYCLE
- Resistance to Tyrosine Kinase Inhibition Therapy for Chronic Myelogenous Leukemia: A Clinical Perspective and Emerging Treatment Options
- (2013) Elias J. Jabbour et al. Clinical Lymphoma Myeloma & Leukemia
- Increased α-Tubulin1b Expression Indicates Poor Prognosis and Resistance to Chemotherapy in Hepatocellular Carcinoma
- (2013) Cuihua Lu et al. DIGESTIVE DISEASES AND SCIENCES
- Taxane Mechanisms of Action: Potential Implications for Treatment Sequencing in Metastatic Castration-resistant Prostate Cancer
- (2013) John M. Fitzpatrick et al. EUROPEAN UROLOGY
- SPARC independent drug delivery and antitumour effects ofnab-paclitaxel in genetically engineered mice
- (2013) Albrecht Neesse et al. GUT
- Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway
- (2013) Jie Ni et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Therapy-induced enrichment of putative lung cancer stem-like cells
- (2013) Daniela P. Freitas et al. INTERNATIONAL JOURNAL OF CANCER
- Increased Chemosensitivity via Targeting Testicular Nuclear Receptor 4 (TR4)-Oct4-Interleukin 1 Receptor Antagonist (IL1Ra) Axis in Prostate Cancer CD133+Stem/Progenitor Cells to Battle Prostate Cancer
- (2013) Dong-Rong Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer
- (2013) Yu Kang et al. JNCI-Journal of the National Cancer Institute
- Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1
- (2013) Francesca Maddalena et al. Molecular Oncology
- The causes and consequences of genetic heterogeneity in cancer evolution
- (2013) Rebecca A. Burrell et al. NATURE
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
- (2013) P Khongkow et al. ONCOGENE
- Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents
- (2013) Kyriacos C. Nicolaou et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
- (2013) A. B. Ward et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
- (2013) Jun-Eul Hwang et al. YONSEI MEDICAL JOURNAL
- Extracellular Vesicles – Biomarkers and Effectors of the Cellular Interactome in Cancer
- (2013) Janusz Rak Frontiers in Pharmacology
- Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205
- (2012) Martin Puhr et al. AMERICAN JOURNAL OF PATHOLOGY
- Expression of β-tubulin III and Survivin in Advance Stage Breast Cancer Correlates with Chemotheraputic Effects of Docetaxel
- (2012) Shao-Fei Yuan et al. Asian Pacific Journal of Cancer Prevention
- Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
- (2012) Josep Domingo-Domenech et al. CANCER CELL
- Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells
- (2012) Wen-Pin Su et al. CARCINOGENESIS
- Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale
- (2012) E. Komlodi-Pasztor et al. CLINICAL CANCER RESEARCH
- Multidrug Resistance-Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma
- (2012) J.-P. Gillet et al. CLINICAL CANCER RESEARCH
- The UCSF-FDA TransPortal: A Public Drug Transporter Database
- (2012) K M Morrissey et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
- (2012) A. Palmeira et al. CURRENT MEDICINAL CHEMISTRY
- Novel Drugs Targeting Microtubules: the Role of Epothilones
- (2012) Gabriella Ferrandina et al. CURRENT PHARMACEUTICAL DESIGN
- Collateral sensitivity as a strategy against cancer multidrug resistance
- (2012) Kristen M. Pluchino et al. DRUG RESISTANCE UPDATES
- P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel
- (2012) Jeroen J.M.A. Hendrikx et al. INTERNATIONAL JOURNAL OF CANCER
- First-Line Treatment of Advanced Breast Cancer With Sunitinib in Combination With Docetaxel Versus Docetaxel Alone: Results of a Prospective, Randomized Phase III Study
- (2012) Jonas Bergh et al. JOURNAL OF CLINICAL ONCOLOGY
- Liposomal paclitaxel formulations
- (2012) Štěpán Koudelka et al. JOURNAL OF CONTROLLED RELEASE
- The effect of some antineoplastic agents on glutathioneS-transferase from human erythrocytes
- (2012) Mustafa Erat et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Genetic heterogeneity and cancer drug resistance
- (2012) Nicholas C Turner et al. LANCET ONCOLOGY
- Expression of survivin and patients survival in non-small cell lung cancer: a meta-analysis of the published studies
- (2012) Li-nian Huang et al. MOLECULAR BIOLOGY REPORTS
- ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells
- (2012) David A Tumbarello et al. Molecular Cancer
- DNA breaks and chromosome pulverization from errors in mitosis
- (2012) Karen Crasta et al. NATURE
- Clonal evolution in cancer
- (2012) Mel Greaves et al. NATURE
- Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
- (2012) Li Ding et al. NATURE
- The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
- (2012) Mar Carmena et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes
- (2012) Claire Corcoran et al. PLoS One
- Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart
- (2012) K. Krishnamurthy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells
- (2012) G M A Ajabnoor et al. Cell Death & Disease
- Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain function
- (2012) David O. Kennedy et al. Advances in Nutrition
- Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy
- (2011) Subash C. Gupta et al. ANTIOXIDANTS & REDOX SIGNALING
- Src family kinases and paclitaxel sensitivity
- (2011) Xiao-Feng Le et al. CANCER BIOLOGY & THERAPY
- Sorcin Induces a Drug-Resistant Phenotype in Human Colorectal Cancer by Modulating Ca2+ Homeostasis
- (2011) F. Maddalena et al. CANCER RESEARCH
- Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice
- (2011) E. A. Hopper-Borge et al. CANCER RESEARCH
- Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
- (2011) D. Lai et al. CANCER RESEARCH
- Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells
- (2011) Y. Zhou et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Natural Taxanes: Developments Since 1828
- (2011) Yu-Fang Wang et al. CHEMICAL REVIEWS
- Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
- (2011) Alina Shapira et al. DRUG RESISTANCE UPDATES
- The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review
- (2011) Naseem Akhtar et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
- (2011) T. Shree et al. GENES & DEVELOPMENT
- Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1
- (2011) Benjamin Boyerinas et al. INTERNATIONAL JOURNAL OF CANCER
- Mitotic Centromere-associated Kinesin (MCAK) Mediates Paclitaxel Resistance
- (2011) Anutosh Ganguly et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial
- (2011) Daniel D. Von Hoff et al. JOURNAL OF CLINICAL ONCOLOGY
- Development of docetaxel-loaded intravenous formulation, Nanoxel-PM™ using polymer-based delivery system
- (2011) Sa-Won Lee et al. JOURNAL OF CONTROLLED RELEASE
- Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer
- (2011) Fiona Furlong et al. JOURNAL OF PATHOLOGY
- Long-Term Androgen Ablation and Docetaxel Up-Regulate Phosphorylated Akt in Castration Resistant Prostate Cancer
- (2011) Takeo Kosaka et al. JOURNAL OF UROLOGY
- The proliferation rate paradox in antimitotic chemotherapy
- (2011) Timothy J. Mitchison MOLECULAR BIOLOGY OF THE CELL
- Overexpression of Mitotic Centromere-Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel
- (2011) A. Ganguly et al. MOLECULAR CANCER THERAPEUTICS
- Mitosis is not a key target of microtubule agents in patient tumors
- (2011) Edina Komlodi-Pasztor et al. Nature Reviews Clinical Oncology
- Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling
- (2011) Lu Gan et al. PROSTATE
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor
- (2010) Sergey Tcherniuk et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage
- (2010) Xing Zeng et al. CANCER CELL
- Class III -Tubulin Expression Predicts Prostate Tumor Aggressiveness and Patient Response to Docetaxel-Based Chemotherapy
- (2010) G. Ploussard et al. CANCER RESEARCH
- Tubulin-Targeting Chemotherapy Impairs Androgen Receptor Activity in Prostate Cancer
- (2010) M.-L. Zhu et al. CANCER RESEARCH
- The β isotypes of tubulin in neuronal differentiation
- (2010) Jiayan Guo et al. Cytoskeleton
- MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells
- (2010) Zhimin Li et al. GYNECOLOGIC ONCOLOGY
- BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer
- (2010) Francesco Crea et al. INTERNATIONAL JOURNAL OF CANCER
- ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells
- (2010) Siddik Sarkar et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Akt Phosphorylation at Ser473 Predicts Benefit of Paclitaxel Chemotherapy in Node-Positive Breast Cancer
- (2010) Sherry X. Yang et al. JOURNAL OF CLINICAL ONCOLOGY
- The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors
- (2010) Yuping Liu et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Targeting of p38 mitogen-activated protein kinases to early growth response gene 1 (EGR-1) in the human paclitaxel-resistance ovarian carcinoma cells
- (2010) Meisong Lu et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains
- (2010) Carlotta Zamparelli et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
- (2010) Ming Zhou et al. Molecular Cancer
- Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells
- (2010) M. Mimeault et al. MOLECULAR CANCER THERAPEUTICS
- Human Mutations That Confer Paclitaxel Resistance
- (2010) S. Yin et al. MOLECULAR CANCER THERAPEUTICS
- Cabazitaxel
- (2010) Matthew D. Galsky et al. NATURE REVIEWS DRUG DISCOVERY
- Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution
- (2010) DaCheng Hao et al. Science China-Life Sciences
- Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxel
- (2009) Dan Su et al. CANCER
- Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer
- (2009) L. Gan et al. CANCER RESEARCH
- Advances and Challenges in Basic and Translational Research on Clusterin
- (2009) I. P. Trougakos et al. CANCER RESEARCH
- A mutation in β-tubulin and a sustained dependence on androgen receptor signalling in a newly established docetaxel-resistant prostate cancer cell line
- (2009) Takahito Hara et al. CELL BIOLOGY INTERNATIONAL
- Phase I and Pharmacokinetic Study of XRP6258 (RPR 116258A), a Novel Taxane, Administered as a 1-Hour Infusion Every 3 Weeks in Patients with Advanced Solid Tumors
- (2009) A. C. Mita et al. CLINICAL CANCER RESEARCH
- Targeting the PI3K signaling pathway in cancer
- (2009) Kwok-Kin Wong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Paclitaxel-resistance Conferred by Altered Expression of Efflux and Influx Transporters for Paclitaxel in the Human Hepatoma Cell Line, HepG2
- (2009) Mikihisa Takano et al. Drug Metabolism and Pharmacokinetics
- Class III β-Tubulin Expression in Tumor Cells is Correlated with Resistance to Docetaxel in Patients with Completely Resected Non-Small-Cell Lung Cancer
- (2009) Yoshiki Hayashi et al. INTERNAL MEDICINE
- How do anti-mitotic drugs kill cancer cells?
- (2009) K. E. Gascoigne et al. JOURNAL OF CELL SCIENCE
- Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III β-tubulin
- (2009) Christos D. Katsetos et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Identification and Characterization of an Intermediate Taxol Binding Site Within Microtubule Nanopores and a Mechanism for Tubulin Isotype Binding Selectivity
- (2009) Holly Freedman et al. Journal of Chemical Information and Modeling
- Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma
- (2009) Steven O'Day et al. JOURNAL OF CLINICAL ONCOLOGY
- Independent Review of E2100: A Phase III Trial of Bevacizumab Plus Paclitaxel Versus Paclitaxel in Women With Metastatic Breast Cancer
- (2009) Robert Gray et al. JOURNAL OF CLINICAL ONCOLOGY
- Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance
- (2009) Yogesh Patil et al. JOURNAL OF CONTROLLED RELEASE
- Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons
- (2009) Jennetta W. Hammond et al. MOLECULAR BIOLOGY OF THE CELL
- Ixabepilone: targeting III-tubulin expression in taxane-resistant malignancies
- (2009) C. Dumontet et al. MOLECULAR CANCER THERAPEUTICS
- Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations To Overcome Multidrug Resistance in Tumor Cells
- (2009) Srinivas Ganta et al. MOLECULAR PHARMACEUTICS
- Effect of Low-Dose Paclitaxel and Docetaxel on Endothelial Progenitor Cells
- (2009) Mariko Muta et al. ONCOLOGY
- Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
- (2009) Aniek Janssen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer
- (2009) A. E. Sayan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: Implications for PSA surrogacy
- (2009) Kenji Kuroda et al. PROSTATE
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
- (2009) Nawneet K. Kurrey et al. STEM CELLS
- Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1®
- (2008) Robert W. Robey et al. BIOCHEMICAL PHARMACOLOGY
- Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis
- (2008) Steffen Blenk et al. BMC CANCER
- Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells
- (2008) G E Konecny et al. BRITISH JOURNAL OF CANCER
- Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs
- (2008) Karen E. Gascoigne et al. CANCER CELL
- Mechanisms of ROS modulated cell survival during carcinogenesis
- (2008) J.S. Clerkin et al. CANCER LETTERS
- Molecular Mechanisms of Patupilone Resistance
- (2008) S. Mozzetti et al. CANCER RESEARCH
- The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms
- (2008) April L. Risinger et al. CANCER RESEARCH
- Stathmin 1: a novel therapeutic target for anticancer activity
- (2008) Shushan Rana et al. Expert Review of Anticancer Therapy
- Microtubules: A dynamic target in cancer therapy
- (2008) Eddy Pasquier et al. IUBMB LIFE
- Design, Synthesis, and Biological Evaluation of New-Generation Taxoids
- (2008) Iwao Ojima et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stathmin Activity Influences Sarcoma Cell Shape, Motility, and Metastatic Potential
- (2008) Barbara Belletti et al. MOLECULAR BIOLOGY OF THE CELL
- Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression
- (2008) J. M-M. Kwok et al. MOLECULAR CANCER THERAPEUTICS
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Tracking the ends: a dynamic protein network controls the fate of microtubule tips
- (2008) Anna Akhmanova et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
- (2008) S.-F. Zhou XENOBIOTICA
- The roles of cys124 and ser239 in the functional properties of human βIII tubulin
- (2008) Patrick A. Joe et al. CELL MOTILITY AND THE CYTOSKELETON
- The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells
- (2008) Daniela A. Brito et al. CELL MOTILITY AND THE CYTOSKELETON
- Taxanes, microtubules and chemoresistant breast cancer
- (2007) Barbara T. McGrogan et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor
- (2007) Stefano Franceschini et al. FASEB JOURNAL
- Hypoxia induces class III beta-tubulin gene expression by HIF-1α binding to its 3' flanking region
- (2007) Giuseppina Raspaglio et al. GENE
- P-glycoprotein: So Many Ways to Turn It On
- (2007) Richard Callaghan et al. JOURNAL OF CLINICAL PHARMACOLOGY
- ABC multidrug transporters: structure, function and role in chemoresistance
- (2007) Frances J Sharom PHARMACOGENOMICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started