Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA

(2013) Rupak Doshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Investigational ABC transporter inhibitors

(2012) Marco Falasca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design and Synthesis of Selenazole-Containing Peptides for Cocrystallization with P-Glycoprotein

(2011) Houchao Tao et al.   CHEMBIOCHEM

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

(2011) Jiangping Bai et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites

(2009) Alena Siarheyeva et al.   BIOCHEMICAL JOURNAL

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels

(2009) Smriti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Functional Role of Transmembrane Helix 6 in Drug Binding and Transport by the ABC Transporter MsbA†

(2008) Barbara Woebking et al.   BIOCHEMISTRY

Functional Characterization ofEscherichia coliMsbA

(2008) Paul D. W. Eckford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY