Review
Oncology
Houssein Chhouri, David Alexandre, Luca Grumolato
Summary: Lung cancer is a leading cause of cancer-related deaths worldwide, and targeted therapies have shown significant improvement in patient outcomes. However, acquired resistance is a common issue leading to tumor relapse. This review discusses the mechanisms of resistance and tolerance to targeted therapy in lung cancer.
Review
Oncology
Mary Luz Uribe, Ilaria Marrocco, Yosef Yarden
Summary: Growth factors like epidermal growth factor (EGF) can promote cell division and migration, but cancer hijacks these mechanisms for tumor growth and metastasis. Over-production and mutations of EGF and EGFR are common in various cancers, making them popular targets for anti-cancer therapies. The activation of EGFR triggers a series of molecular switches controlling gene expression, with implications for drug resistance and metastasis.
Article
Cell Biology
Christine Parseghian, Madhulika Eluri, Scott Kopetz, Kanwal Raghav
Summary: This article discusses the development of acquired resistance to anti-EGFR therapies, highlighting the predominance of transcriptomic mechanisms of resistance in first-line treatment and acquired MAPK mutations in later-line treatment. It emphasizes the importance of prospective studies guided by acquired MAPK mutations in evaluating anti-EGFR rechallenge strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Ke-Ren Zhang, Yu-Fei Zhang, Hui-Min Lei, Ya-Bin Tang, Chun-Shuang Ma, Qian-Ming Lv, Shi-Yi Wang, Li-Ming Lu, Ying Shen, Hong-Zhuan Chen, Liang Zhu
Summary: The study uncovered a metabolic mechanism driving resistance to EGFR TKIs by promoting cystine metabolism, and suggested AKR1B1 as a potential therapeutic target to overcome resistance to EGFR TKIs.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Stefania Pizzimenti, Simone Ribero, Marie Angele Cucci, Margherita Grattarola, Chiara Monge, Chiara Dianzani, Giuseppina Barrera, Giuliana Muzio
Summary: Melanoma is a highly aggressive cancer with activating mutations in BRAF being the most common genetic alterations. Targeted inhibitors have improved survival rates in advanced melanoma patients, but resistance still develops in around 50% of patients within the first year of therapy, presenting a significant challenge in managing BRAF-mutated advanced melanoma. Understading the mechanisms of resistance, including genetic, epigenetic, and oxidative stress-related factors, is crucial in developing effective therapies.
Article
Oncology
Yu-Ra Choi, Youngnam Cho, Seog-Yun Park, Sunshin Kim, Myungsun Shin, Yongdoo Choi, Dong Hoon Shin, Ji-Youn Han, Youngjoo Lee
Summary: This study investigates the expansion of resistant cancer cells in response to EGFR inhibitors and suggests that early on-treatment kinetics of resistance-related gene alterations may predict the final mechanism of EGFR-TKI resistance. These findings provide insights into the development of EGFR-TKI resistance.
Article
Cell Biology
Shigetoshi Nishihara, Toshimitsu Yamaoka, Fumihiro Ishikawa, Tohru Ohmori, Koichi Ando, Sojiro Kusumoto, Yasunari Kishino, Ryo Manabe, Yuki Hasebe, Hironori Sagara, Hitoshi Yoshida, Junji Tsurutani
Summary: This study investigated the mechanisms of osimertinib resistance in NSCLC cells and identified diverse resistance mechanisms. The findings provide insights for developing novel therapeutic strategies for NSCLC.
Article
Multidisciplinary Sciences
Helen S. Mueller, Colin E. Fowler, Simona Dalin, Enrico Moiso, Tee Udomlumleart, Salil Garg, Michael T. Hemann, Jacqueline A. Lees
Summary: Epigenetic regulators are crucial in cancer treatment, but resistance mechanisms to their inhibition are not well understood. A study on PRMT5 inhibitors in lung adenocarcinoma cell lines revealed a drug-induced transcriptional switch leading to rapid resistance. The resistant state, stabilized across LUAD variants, also showed vulnerabilities to other chemotherapeutics like paclitaxel, due to the presence of STMN2. This gene was found to be essential for both PRMT5 inhibition resistance and sensitivity to paclitaxel, highlighting a potential therapeutic combination for cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Rui-Fang Dong, Miao-Lin Zhu, Ming-Ming Liu, Yi-Ting Xu, Liu-Liu Yuan, Jing Bian, Yuan-Zheng Xia, Ling-Yi Kong
Summary: The article discusses the mechanisms of EGFR-TKIs resistance induced by secondary EGFR mutations, such as T790M and C797S. It highlights the development of targeted drugs to overcome resistance mediated by EGFR mutations.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Noura J. Choudhury, Antonio Marra, Jane S. Y. Sui, Jessica Flynn, Soo-Ryum Yang, Christina J. Falcon, Pier Selenica, Adam J. Schoenfeld, Natasha Rekhtman, Daniel Gomez, Michael F. Berger, Marc Ladanyi, Maria Arcila, Charles M. Rudin, Gregory J. Riely, Mark G. Kris, Glenn Heller, Jorge S. Reis-Filho, Helena A. Yu
Summary: The study explores the potential of identifying and intervening on molecular markers associated with therapeutic resistance to improve patient outcomes in metastatic EGFR-mutant lung cancer treated with first-line osimertinib. Baseline atypical EGFR and concurrent TP53/RB1 alterations are associated with shorter progression-free survival on first-line osimertinib. Tissue-based genomic analysis allows for treatment adaptation based on identified mechanisms of resistance at the time of progression, leading to improved postprogression survival.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Oncology
Neal S. Akhave, Amadeo B. Biter, David S. Hong
Summary: KRAS mutations drive cancer growth, but the development of resistance to targeted therapies remains a challenge. Understanding the mechanisms of resistance and developing combination strategies are crucial for long-term disease control.
Review
Oncology
Shi-Yong Sun
Summary: A significant clinical challenge in lung cancer treatment is managing acquired resistance to third-generation EGFR-TKIs, especially osimertinib. Inducing apoptosis and restoring cell sensitivity to undergo apoptosis promise to be effective strategies for overcoming acquired resistance to EGFR-TKIs.
FRONTIERS OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yue Zeng, Yuanqing Feng, Guihua Fu, Junlan Jiang, Xiaohan Liu, Yue Pan, Chunhong Hu, Xianling Liu, Fang Wu
Summary: The acquired resistance of EGFR-TKIs is inevitable and heterogeneous. Osimertinib is the standard second-line therapy for T790M-positive patients, but its efficacy in patients with concurrent multiple driver gene resistance is unclear. The T790M accompanying other driver gene resistance will be a new subtype, requiring new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Alejandro Rios-Hoyo, Laura Moliner, Edurne Arriola
Summary: Osimertinib has revolutionized the treatment of EGFR-mutated tumors, but resistance mechanisms inevitably develop. Understanding and studying these resistance mechanisms is crucial for developing effective therapeutic strategies.
Article
Oncology
Helei Hou, Dantong Sun, Chuantao Zhang, Dong Liu, Xiaochun Zhang
Summary: This study identified ALK rearrangement as a potential mechanism of acquired resistance to osimertinib in NSCLC patients with EGFR sensitive mutations. Combination therapy of osimertinib and crizotinib maintained stable disease, while chemotherapy plus bevacizumab was identified as an optimal treatment, especially for patients harboring VEGFA amplification.
Article
Engineering, Environmental
Woosung Jo, Kihoon Jeong, Young-Sam Park, Jeong-Ik Lee, Sung Gap Im, Taek-Soo Kim
Summary: In this study, a thermally stable yet soft pressure-sensitive adhesive (PSA) was synthesized via initiated chemical vapor deposition (iCVD), exhibiting excellent mechanical properties and reliability at the operating temperature of foldable devices.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Keonyong Lee, Kate Molloy O'Neill, Jayoung Ku, Stanislav Yefimovic Shvartsman, Yoosik Kim
Summary: The segmentation of the Drosophila embryo is regulated by localized maternal signals, including Bicoid and Nanos. The terminal system, controlled by mitogen-activated protein kinase, patterns the non-segmented termini. However, the spatial extent of this system in regulating gap genes beyond poles is unknown. Through study on mutagenized embryos, researchers discovered that the terminal system can establish multiple gene expression boundaries along the anteroposterior axis, displaying a potential bistability.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Physical
Jaehyoung Ko, Daeun Kim, Giho Sim, Se Youn Moon, Sang Seok Lee, Se Gyu Jang, Seokhoon Ahn, Sung Gap Im, Yongho Joo
Summary: Boron nitride nanotube (BNNT) has attracted attention due to its exceptional material properties, but practical implementation has been difficult due to purity issues. In this study, a scalable purification method for BNNT was developed using aqueous polymer two-phase extraction, achieving a high purity level of >98%. The method was successfully scaled up and the purified BNNT exhibited liquid crystal behavior. This large-scale purification effort is expected to contribute to the macroscopic realization of BNNT's exceptional properties in the future.
Article
Biophysics
Jayeon Song, Younseong Song, Hyowon Jang, Jeong Moon, Hyunju Kang, Yong-Min Huh, Hye Young Son, Hyun Wook Rho, Mirae Park, Eun-Kyung Lim, Juyeon Jung, Yongwon Jung, Hyun Gyu Park, Kyoung G. Lee, Sung Gap Im, Taejoon Kang
Summary: Accurate and efficient DNA detection is crucial for disease diagnosis and health monitoring. This study presents a one-step elution-free DNA analysis method based on the combination of CRISPR/Cas9-mediated CLAT assay and a DNA-capturing pDMAMS-coated tube. The combination simplifies DNA detection in a single tube without the need for complicated extraction steps, improving sensitivity. The platform demonstrates attomolar sensitivity in various samples and shows potential applications in tissue and liquid biopsies.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Jimin Yoon, Doyeong Ku, Minseok Lee, Namseok Lee, Sung Gap Im, Yoosik Kim
Summary: Human mitochondria contain a circular genome that encodes 13 subunits of the oxidative phosphorylation system. Mitochondria can generate long double-stranded RNAs (mt-dsRNAs) that are closely associated with the pathogenesis of human diseases. Resveratrol (RES), a plant-derived polyphenol, has the potential to suppress mt-dsRNA-mediated immune activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chang Hyun Nam, Jeonghwan Youk, Jeong Yeon Kim, Joonoh Lim, Jung Woo Park, Soo A. Oh, Hyun Jung Lee, Ji Won Park, Hyein Won, Yunah Lee, Seung-Yong Jeong, Dong-Sung Lee, Ji Won Oh, Jinju Han, Junehawk Lee, Hyun Woo Kwon, Min Jung Kim, Young Seok Ju
Summary: This study uncovers the mutational landscape induced by L1 retrotransposition in normal cells and reveals a positive relationship between somatic L1 retrotransposition and age.
Article
Medicine, General & Internal
Jinkyeong Park, Yoonki Hong, Ji Young Hong
Summary: This study investigated the risk factors for multidrug-resistant tuberculosis (MDR-TB) in patients with pulmonary TB. The research found that patients who had received anti-tumor necrosis factor (TNF) agents had a higher risk of developing MDR-TB. Additionally, males and younger patients were also more susceptible to MDR-TB.
FRONTIERS IN MEDICINE
(2023)
Meeting Abstract
Oncology
Gene Li, Ling Wang, Poonam Yakkundi, Paul Hinton, Deepal Pandya, Keerthana Sekar, Rodine Rosete, Zhongde Ye, Nardeen Hanna, Maya F. Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Thomas Manley, Bruce A. Keyt, Angus M. Sinclair, Liqin Liu
Review
Biochemistry & Molecular Biology
Insook Ahn, Chanhee S. Kang, Jinju Han
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Respiratory System
Taehee Kim, Sang Hyuk Kim, Hayoung Choi, Tae Rim Shin, Hwan Il Kim, Seung Hun Jang, Ji Young Hong, Myung Goo Lee, Soojie Chung, In Gyu Hyun, Yun Su Sim
Meeting Abstract
Respiratory System
Jeongmi Lee, Yoonki Hong, Ji-Young Hong, Jinkyeong Park
Meeting Abstract
Respiratory System
Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, Gee Young Suh
Article
Materials Science, Multidisciplinary
Jin Ryu, Myung Seok Oh, Jongsun Yoon, Minjeong Kang, Jae Bem You, Hyomin Lee, Sung Gap Im
Summary: Recent advances in wearable and embeddable displays have increased the demand for functional coatings that are stretchable and maintain high optical transparency in fogging conditions. A conformal antifogging polymer thin film with exceptional stretchability was synthesized using initiated chemical vapor deposition (iCVD). This film offers excellent antifogging performance and high elasticity, and outperforms commercial antifogging spray coatings in transmittance, even in hot water vapor, cold-fog transition tests, and when stretched.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Review
Biochemistry & Molecular Biology
Mingyu Ju, Dayeon Kim, Geurim Son, Jinju Han
Summary: RNAs, versatile molecules primarily involved in gene regulation, could be widely used in therapeutics and diagnostics. Circular RNAs (circRNAs), highly stable in nature, have emerged as strong candidates for next-generation therapeutic platforms. circRNAs control gene regulatory networks through interactions with biomolecules or translation, exhibit cell-type specific expression patterns, and can serve as biomarkers or therapeutic targets in diseases. Additionally, synthetic circRNAs can be introduced into cells to modulate gene expression networks, either identical or artificially designed, showing their potential in therapeutic applications.
MOLECULES AND CELLS
(2023)