Determinants and clinical implications of chromosomal instability in cancer

Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells

(2017) Yan Gao et al.   GENOME RESEARCH

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

(2017) Samra Turajlic et al.   LANCET ONCOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence

(2017) Damiana D.C.G. Pierssens et al.   ORAL ONCOLOGY

Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer

(2017) Jacqueline M. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

(2017) Teresa Davoli et al.   SCIENCE

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

(2017) Inma M. Berenjeno et al.   Nature Communications

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

(2017) Tohru Takaki et al.   Nature Communications

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

(2017) Laurent Sansregret et al.   Cancer Discovery

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

(2016) H.-S. Lee et al.   CANCER RESEARCH

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

(2016) Mathieu Chicard et al.   CLINICAL CANCER RESEARCH

The Combination of DNA Ploidy Status and PTEN/6q15 Deletions Provides Strong and Independent Prognostic Information in Prostate Cancer

(2016) M. Lennartz et al.   CLINICAL CANCER RESEARCH

The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance

(2016) Stacie E. Dodgson et al.   GENES & DEVELOPMENT

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

(2016) Sarah J. Pfau et al.   GENES & DEVELOPMENT

Evolution of genetic instability in heterogeneous tumors

(2016) Ani D. Asatryan et al.   JOURNAL OF THEORETICAL BIOLOGY

Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53

(2016) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity

(2016) A. M. Wengner et al.   MOLECULAR CANCER THERAPEUTICS

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

(2016) Andrew McPherson et al.   NATURE GENETICS

Single-cell genome sequencing: current state of the science

(2016) Charles Gawad et al.   NATURE REVIEWS GENETICS

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells

(2016) K. M. Godek et al.   Cancer Discovery

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells

(2016) Bernardo Orr et al.   Cell Reports

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

(2016) Konstantina Rowald et al.   Cell Reports

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

How to count chromosomes in a cell: An overview of current and novel technologies

(2015) Bjorn Bakker et al.   BIOESSAYS

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

(2015) Anastasia Y Kuznetsova et al.   CELL CYCLE

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Revisiting tumour aneuploidy — the place of ploidy assessment in the molecular era

(2015) Håvard E. Danielsen et al.   Nature Reviews Clinical Oncology

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

(2015) Nicholas McGranahan et al.   Science Translational Medicine

Numerical chromosomal instability mediates susceptibility to radiation treatment

(2015) Samuel F. Bakhoum et al.   Nature Communications

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

(2015) Ashley M. Laughney et al.   Cell Reports

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer

(2014) E. Schutz et al.   CLINICAL CHEMISTRY

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

(2014) Dejan Juric et al.   NATURE

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

(2014) Norman Ertych et al.   NATURE CELL BIOLOGY

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

(2014) E. C. de Bruin et al.   SCIENCE

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis

(2013) J. M. Sheltzer   CANCER RESEARCH

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Gene Copy-Number Alterations: A Cost-Benefit Analysis

(2013) Yun-Chi Tang et al.   CELL

Immunosurveillance against tetraploidization-induced colon tumorigenesis

(2013) Alice Boilève et al.   CELL CYCLE

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

(2013) Ciorsdaidh A. Watts et al.   CHEMISTRY & BIOLOGY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

Tumor Environmental Factors Glucose Deprivation and Lactic Acidosis Induce Mitotic Chromosomal Instability – An Implication in Aneuploid Human Tumors

(2013) Chunyan Dai et al.   PLoS One

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

(2013) Miyako Kondoh et al.   PLoS One

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

(2012) Guangbo Chen et al.   NATURE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle

(2012) Michael Hesse et al.   Nature Communications

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells

(2012) Judit Pampalona et al.   PLoS Genetics

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

(2011) R. Roylance et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics

(2011) J. D. Orth et al.   CANCER RESEARCH

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

A non-genetic route to aneuploidy in human cancers

(2011) Matej Krajcovic et al.   NATURE CELL BIOLOGY

Mitosis is not a key target of microtubule agents in patient tumors

(2011) Edina Komlodi-Pasztor et al.   Nature Reviews Clinical Oncology

Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure

(2011) Laurent Sansregret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Constitutional aneuploidy and cancer predisposition

(2009) I. Ganmore et al.   HUMAN MOLECULAR GENETICS

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

(2008) A Walther et al.   GUT

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

The cell biology of cell-in-cell structures

(2008) Michael Overholtzer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE