Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Huang, PingPing Zhou, ShanShan Li, Kaiyan Li
Summary: This study showed that dynamic contrast-enhanced ultrasonography (DCE-US) parameters are related to Ki-67 expression in patients with hepatocellular carcinoma (HCC). There were significant differences in clinicopathological features between the high and low Ki-67 expression groups. Certain parameters in the arterial phase and Kupffer phase were significantly different between HCC lesions and distal liver parenchyma, and these differences may contribute to a more accurate diagnosis of the high Ki-67 expression group.
INSIGHTS INTO IMAGING
(2022)
Article
Medicine, General & Internal
Hoa-Jan Lei, Sheng-Yu Wang, Ivy Yenwen Chau, Anna Fen-Yau Li, Yat-Pang Chau, Cheng-Yuan Hsia, Shu-Cheng Chou, Yi-Chu Kao, Gar-Yang Chau
Summary: In patients with hepatocellular carcinoma, HURP expression was found to be associated with certain clinicopathologic features, but not post-resection survival, while Ki-67 expression was identified as an independent prognostic factor for survival. The impact of HURP activity on HCC growth, invasion, and post-resection outcomes in actual patients may be less significant than previously suggested by experimental studies.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Oncology
Cuiyun Wu, Junfa Chen, Yuqian Fan, Ming Zhao, Xiaodong He, Yuguo Wei, Weidong Ge, Yang Liu
Summary: This study developed a radiomics nomogram based on CT radiomics signature and clinical factors for the individualized prediction of Ki-67 expression in HCC. The nomogram showed good performance in predicting high Ki-67 expression and can provide guidance for treatment and clinical monitoring of HCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Jialiang Cai, Suiyi Wu, Feng Zhang, Zhi Dai
Summary: An EGRscore was constructed to evaluate the prognosis, mutation pattern, and immune microenvironment of liver hepatocellular carcinoma (LIHC) and other tumors. The study found that there were differences in TP53 mutation profiles, immune cell composition, and drug resistance genes between EGRscore-high and EGRscore-low patients. Furthermore, EGRscore-low patients showed a higher response rate to immunotherapy and targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jianwei Xie, YaJun Zhao, Yanbing Zhou, Qingliang He, Hankun Hao, Xiantu Qiu, Gang Zhao, Yanchang Xu, Fangqin Xue, Jinping Chen, Guoqiang Su, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study focused on the long-term outcomes of patients with grade 3 gastric neuroendocrine carcinoma (GNEC) who underwent curative surgery, finding that combining carcinoembryonic antigen (CEA) levels and Ki-67 index can predict patient prognosis. A nomogram was constructed to predict patient survival, showing that the combination of Ki-67 status and AJCC 8th stage performed better in predicting prognosis than the AJCC 8th stage alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ganbin Qiu, Jincan Chen, Weixiong Liao, Yonghui Liu, Zhongyan Wen, Yue Zhao
Summary: This study explored the predictive value of gadoxetic acid-enhanced MRI combined with T1 mapping and clinical factors for Ki-67 expression in HCC. A predictive nomogram based on significant factors showed high accuracy in predicting Ki-67 LI, enabling personalized treatment and risk stratification of HCC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Acoustics
Linlin Zhang, Shaobo Duan, Qinghua Qi, Qian Li, Shanshan Ren, Shunhua Liu, Bing Mao, Ye Zhang, Simeng Wang, Long Yang, Ruiqing Liu, Luwen Liu, Yaqiong Li, Na Li, Lianzhong Zhang
Summary: Ultrasomics was proven to be a potential noninvasive method to predict Ki-67 expression in hepatocellular carcinoma (HCC). The combination of ultrasomics and clinical features significantly improved the predictive performance of the model on all three datasets.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Oncology
Qixin Liu, Ziheng Peng, Liangfang Shen, Lin Shen
Summary: Ki-67 overexpression is associated with poor overall survival rates in melanoma patients, but not correlated with PFS and RFS rates. Ki-67 expression levels are associated with tumor thickness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Jianqing Yu, Xianfeng Xia, Yujuan Dong, Zhongqin Gong, Gang Li, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 is significantly down-regulated in HCC tumor tissues and its high expression is associated with better prognosis. CYP1A2 functions as a tumor suppressor in HCC by inhibiting HGF/MET signaling and MMPs expression, thus reducing cell growth and invasion capabilities.
Article
Oncology
Ziwei Liu, Shaomin Yang, Xinjie Chen, Chun Luo, Jieying Feng, Haixiong Chen, Fusheng Ouyang, Rong Zhang, Xiaohong Li, Wei Liu, Baoliang Guo, Qiugen Hu
Summary: T1rt-Pre and T1rt-20min showed strong positive correlation with Ki-67 expression in HCC, and the nomogram based on Gd-EOB-DTPA enhanced MRI combined with T1 mapping effectively predicted high Ki-67 expression in HCC with good concordance indices in the training and validation cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Koji Okudela, Tetsukan Woo, Yusuke Saigusa, Hiromasa Arai, Mai Matsumura, Hideaki Mitsui, Misaki Sugiyama, Motoki Sekiya, Yoshihiro Ishikawa, Hisashi Oshiro, Yoichi Kameda, Kenichi Ohashi
Summary: This study optimized a procedure for measuring the Ki-67 index in lung adenocarcinoma and established the best cut-off value. Using the SP6 antibody for immunohistochemical staining, they successfully developed an optimal procedure for determining the Ki-67 labeling index. They identified an optimal cut-off value of 0.12 and achieved a coverage probability >70% and a confidence interval of <0.05 in over 90% of cases.
Article
Oncology
Dirk Andreas Ridder, Arndt Weinmann, Mario Schindeldecker, Lana Louisa Urbansky, Kristina Berndt, Tiemo Sven Gerber, Hauke Lang, Johannes Lotz, Karl J. Lackner, Wilfried Roth, Beate Katharina Straub
Summary: AFP is a commonly used biomarker for HCC, with its serum concentration moderately correlated to in situ expression. High AFP levels in serum and tissue are associated with poor prognosis, vascular invasion, higher tumor grade, and specific tumor subtype. Serum AFP concentration is a stronger prognostic predictor independent of tissue AFP immunostaining.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Baohui Zhang, Bufu Tang, Jiarui Lv, Jianyao Gao, Ling Qin
Summary: This study aimed to develop an improved prognostic signature based on tumor immune microenvironment (TIME) for hepatocellular carcinoma (HCC). By analyzing HCC patients from TCGA and ICGC databases, immune-related genes associated with patient prognosis were identified, and a prognostic model was established. High-risk patients showed worse survival outcomes and poorer response to chemotherapy, but could potentially benefit from immunotherapy. Silencing IGF2BP3 significantly inhibited cell proliferation and migration in HCC. This immune-related model may aid in precise diagnosis and treatment of HCC.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yu Meng, Quan Quan, Fenfen Zhang, Yao Liu, Siling Ren, Xiaoling Mu
Summary: This study investigated the prognostic value of the Ki-67 index in endometrial stromal sarcoma and identified a cut-off value of 35% for predicting recurrence. High Ki-67 index and ovarian preservation were significantly associated with shorter progress free survival. The Ki-67 index could serve as a useful prognostic marker in endometrial stromal sarcoma.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-meng Zhao, Shuang-shuang Xie, Jian Wang, Ya-min Zhang, Wen-Cui Li, Zhao-Xiang Ye, Wen Shen
Summary: This study aimed to develop a CT model to predict Ki-67 expression in HCC and evaluate the added value of radiomics. The CR model combining clinical and CE-CT features showed good performance in predicting Ki-67 expression. However, radiomics did not provide additional value.
BMC MEDICAL IMAGING
(2023)
Article
Gastroenterology & Hepatology
Huiyuan Qiu, Xiubing Zhang, Wenkai Ni, Weidong Shi, Hui Fan, Jian Xu, Yongmei Chen, Runzhou Ni, Tao Tao
DIGESTIVE DISEASES AND SCIENCES
(2016)
Article
Oncology
Baoying Hu, Xia Yan, Fang Liu, Changlai Zhu, Huiling Zhou, Yuyan Chen, Jinxia Liu, Xingxing Gu, Runzhou Ni, Tianyi Zhang
PATHOLOGY & ONCOLOGY RESEARCH
(2016)
Article
Oncology
Lei Yang, Jun-ya Zhu, Jian-guo Zhang, Bo-jun Bao, Cheng-qi Guan, Xiao-jing Yang, Yan-hua Liu, Yue-jiao Huang, Run-zhou Ni, Li-li Ji
Article
Gastroenterology & Hepatology
Jinxia Liu, Wenkai Ni, Lishuai Qu, Xiaopeng Cui, Zhipeng Lin, Qingqing Liu, Huiling Zhou, Runzhou Ni
DIGESTIVE DISEASES AND SCIENCES
(2016)
Article
Gastroenterology & Hepatology
Lingling Chen, Sujie Ni, Mei Li, Chaoyan Shen, Zhipeng Lin, Yu Ouyang, Fei Xia, Li Liang, Wenyan Jiang, Runzhou Ni, Jianguo Zhang
DIGESTIVE DISEASES AND SCIENCES
(2017)
Article
Pathology
Jinxia Liu, Xiaopeng Cui, Lishuai Qu, Lu Hua, Miaomiao Wu, Zhongyi Shen, Cuihua Lu, Runzhou Ni
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Huiyuan Qiu, Fang Liu, Tao Tao, Dongmei Zhang, Xiaojuan Liu, Guizhou Zhu, Zhiwei Xu, Runzhou Ni, Aiguo Shen
MOLECULAR CARCINOGENESIS
(2017)
Article
Pathology
Han Wu, Liang Wang, Dongmei Zhang, Ji Qian, Lijun Yan, Qiyun Tang, Runzhou Ni, Xiaoping Zou
PATHOLOGY RESEARCH AND PRACTICE
(2017)
Article
Medicine, Research & Experimental
Jiao-Jiao Yang, Hua Huang, Ming-Bing Xiao, Feng Jiang, Wen-Kai Ni, Yi-Fei Ji, Cui-Hua Lu, Run-Zhou Ni
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Oncology
Mingbing Xiao, Tao Li, Yifei Ji, Feng Jiang, Wenkai Ni, Jing Zhu, Baijun Bao, Cuihua Lu, Runzhou Ni
Article
Gastroenterology & Hepatology
Lijun Yan, Liang Wang, Jian'an Bai, Xianjing Miao, Weiwen Zeng, Xiumei Hua, Runzhou Ni, Dongmei Zhang, Qiyun Tang
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2017)
Article
Pathology
Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Liu
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Pathology
Zhaoxiu Liu, Chengqi Guan, Cuihua Lu, Yanmei Liu, Runzhou Ni, Mingbing Xiao, Zhaolian Bian
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Oncology
C. Zhang, C. Li, X. Chen, Y. Zhou, B. Yin, R. Ni, Y. Zhang, J. Liu
CLINICAL & TRANSLATIONAL ONCOLOGY
(2017)
Article
Medicine, Research & Experimental
Jinxia Liu, Cuihua Lu, Mingbing Xiao, Feng Jiang, Lishuai Qu, Runzhou Ni
BIOMEDICINE & PHARMACOTHERAPY
(2017)