Review
Pharmacology & Pharmacy
Dongqin Xia, Wenjie Li, Ce Tang, Juan Jiang
Summary: Cancer is increasing in developing countries with unsatisfactory outcomes from traditional cancer treatments. Traditional Chinese medicine (TCM) components, such as Astragaloside IV (AS-IV), have shown significant anticancer activities. AS-IV has various effects, including modulation of enzyme activities, cell cycle arrest, apoptosis and autophagy induction, and suppression of cancer progression. This article reviews the bioavailability, anticancer activity, and mechanism of AS-IV and provides suggestions for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdur Rauf, Tareq Abu-Izneid, Anees Ahmed Khalil, Muhammad Imran, Zafar Ali Shah, Talha Bin Emran, Saikat Mitra, Zidan Khan, Fahad A. Alhumaydhi, Abdullah S. M. Aljohani, Ishaq Khan, Md Mominur Rahman, Philippe Jeandet, Tanweer Aslam Gondal
Summary: Berberine, a potential bioactive agent, shows remarkable health benefits and promising anticancer activity. It inhibits cancer cell proliferation, invasion, and metastasis through various mechanisms, and also plays a role in the early stages of cancer development. Despite its potential, pure berberine preparations for specific ailments are currently not approved, but research on its sources, extraction methods, pharmacokinetics, and proposed mechanisms of action related to its anticancer potential continues.
Review
Medicine, Research & Experimental
YingZheng Wang, Tong Wang, HuaXin Wang, WeiDong Liu, Xiao Li, XiaoYan Wang, YaNan Zhang
Summary: The antitumor effects of traditional drugs have received attention and active antitumor components extracted from traditional drugs have shown good efficacy. Cepharanthine (CEP) is an active component derived from Stephania plants that can inhibit tumor progression through multiple signaling pathways. By summarizing recent studies on CEP's antitumor effects and mechanism, this review aims to provide new insights and a theoretical basis for further development and application of CEP.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Gulay Ozkan, Deniz Gunal-Koroglu, Ayse Karadag, Esra Capanoglu, Susana M. Cardoso, Basem Al-Omari, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: This comprehensive review examines the anticancer mechanisms of lycopene through in vivo and in vitro research, highlighting the experimental conditions. Relevant scientific pharmacological articles were collected from multiple databases, investigating the molecular action and cellular effects of lycopene in various tumors. The anticancer potential of lycopene is attributed to its singlet-oxygen quencher characteristics, stimulation of detoxifying enzymes, initiation of apoptosis, inhibition of cell proliferation and cycle progression, as well as modulation of gap junctional communication, growth factors, and signal transduction pathways. Factors such as dose, drug delivery systems, cancer type, tumor size, and treatment time are crucial in determining the anticancer properties of lycopene.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Xiaofeng Wang, Qingqing Liu, Yuanfeng Fu, Ren-Bo Ding, Xingzhu Qi, Xuejun Zhou, Zhihua Sun, Jiaolin Bao
Summary: This review summarizes the latest advances in preclinical studies on the anticancer properties of magnolol. It highlights its ability to inhibit cancer growth and metastasis and its mechanism of action through multiple signaling pathways. Magnolol shows promise as a potential candidate for cancer therapy.
Review
Oncology
Noor Azleen Mohamad, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir
Summary: This review summarizes the medicinal properties of Piper betle leaves and their potential as an anticancer agent. The primary constituent, Hydroxychavicol (HC), has been found to possess antiproliferative activity against various cancer cell lines while leaving normal cells unharmed. The review also discusses the mechanisms of action of HC and suggests future research directions.
Review
Pharmacology & Pharmacy
Saikat Mitra, Rajib Das, Talha Bin Emran, Rafiuddin Khan Labib, Noor-E-Tabassum, Fahadul Islam, Rohit Sharma, Islamudin Ahmad, Firzan Nainu, Kumarappan A. Chidambaram, Fahad A. Alhumaydhi, Deepak Chandran, Raffaele Capasso, Polrat Wilairatana
Summary: Garlic, a widely used plant medicinal product, contains a compound called diallyl disulfide (DADS) that has shown anticancer effects against various types of tumors, including gynecological, hematological, lung, and gastrointestinal cancers. The mechanisms of action of DADS against cancer cells involve regulating epithelial-mesenchymal transition and inhibiting invasion and migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wen Zhang, Chaoying Lu, Shuhui Cai, Yaru Feng, Jinjun Shan, Liuqing Di
Summary: Aconiti Lateralis Radix Praeparata (Fuzi) is a traditional herbal medicine widely used in China and other Asian countries, with considerable anticancer, anti-inflammatory, and analgesic effects. Its main components, alkaloids and polysaccharides, have been shown to induce apoptosis and autophagy, inhibit proliferation, migration and invasion, regulate immune function, and affect energy metabolism, making them attractive candidates for anticancer drug development.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Anchal Trivedi, Adria Hasan, Rumana Ahmad, Sahabjada Siddiqui, Aditi Srivastava, Aparna Misra, Snober S. Mir
Summary: Good nutrition is essential for a balanced lifestyle. Nutraceuticals, especially flavonoids found in fruits, vegetables, tea, cocoa, and wine, have been proven to have various health benefits, including anti-inflammatory, anti-allergic, anti-microbial, antioxidant, and anticancer properties. Myricetin, a flavonol present in fruits and vegetables, has shown potential as a nutraceutical that can protect against cancer. This review focuses on discussing recent studies on the anticancer potential of myricetin and the molecular mechanisms involved, aiming to contribute to the development of a novel anticancer nutraceutical with minimal side effects.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
A. Ram Kumar, S. Selvaraj, Mohammad Azam, G. P. Sheeja Mol, N. Kanagathara, Mahboob Alam, P. Jayaprakash
Summary: The geometric structure, vibrational frequencies, solvent effects, and various properties of lemonol were investigated experimentally and theoretically. The results showed its stability and reactivity, as well as its binding sites and weak interactions. The in vitro studies confirmed the structure and demonstrated that lemonol acts as a potent inhibitor against the MCF-7 breast cancer cell line.
Review
Pharmacology & Pharmacy
Fang-Yuan Liu, Dan-Ni Ding, Yun-Rui Wang, Shao-Xuan Liu, Cheng Peng, Fang Shen, Xiao-Ya Zhu, Chan Li, Li-Ping Tang, Feng-Juan Han
Summary: Many chemical compounds from natural herbs, including icariin, have been studied for their potential in cancer treatment due to their various beneficial properties. However, there is a lack of comprehensive review on icariin's role in cancer treatment. This study aims to fill this gap by examining and summarizing the relevant literature on icariin's chemopreventive and therapeutic potentials in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Adelina Simamora, Kris Herawan Timotius, Mukerrem Betul Yerer, Heri Setiawan, Abdul Mun'im
Summary: Xanthorrhizol (XTZ), a bisabolene sesquiterpenoid, has anticancer activities and multiple pharmacological effects. Studies have shown that XTZ has preventive and therapeutic effects against various types of cancer, and it inhibits the growth and metastasis of cancer cells by regulating multiple signaling pathways.
Article
Multidisciplinary Sciences
Savinee Chanvijit, Suttinee Phuagkhaopong, Panupong Mahalapbutr, Methus Klaewkla, Warinthorn Chavasiri, Piyanuch Wonganan
Summary: The study found that Mansonone G (MG) and its derivatives exhibited concentration-dependent cytotoxicity on CRC cell lines, with allyl ether mansonone G (MG7) being the most toxic. MG7 induced ROS generation and apoptosis, and modulated protein expression and signaling pathways related to cell survival and proliferation. Molecular docking analysis revealed the potential binding of MG7 to ATP-binding pockets of AKT and ERK1 proteins.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Siqi Xiao, Zehua Lu, Jianmin Yang, Xianai Shi, Yunquan Zheng
Summary: In this study, researchers found that the phycocyanobilin compound in phycocyanin can be used as a new anticancer photosensitizer with anti-inflammatory and immunomodulatory activities. The compound was produced rapidly with high purity and showed significant anticancer activity under light conditions. Its active oxygen quantum yield was much higher than that of chlorophyll, making it a promising candidate for cancer treatment.
Article
Plant Sciences
Eman Fikry, Raha Orfali, Samar S. Elbaramawi, Shagufta Perveen, Azza M. El-Shafae, Maher M. El-Domiaty, Nora Tawfeek
Summary: Cancer is a major cause of death globally, and the essential oil from Chamaecyparis lawsoniana leaves (CLLEO) shows potential anticancer properties, making it a possible alternative treatment option.