Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Review
Oncology
Parham Jabbarzadeh Kaboli, Saber Imani, Masume Jomhori, King-Hwa Ling
Summary: Breast cancer displays poor response to conventional chemotherapy due to the activation of Akt signaling, which is considered a key factor in intrinsic and acquired drug resistance. Akt signaling not only enhances multi-drug resistance, but also plays crucial roles in cellular metabolism, apoptosis, and other processes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Shaghayegh Abaft, Fatemeh Jamali, Pardis Safaiepour, Kiyana Narimisa, Gloria Jackson, Anusha Bishayee, Nima Rezaei, Amir Hossein Abdolghaffari, Anupam Bishayee
Summary: The importance of the PI3K/Akt/mTOR pathway in prostate cancer treatment and the clinical applications of natural agents and small molecule inhibitors targeting this pathway are discussed in the study. Research suggests that natural mTOR inhibitors can interfere with the PI3K/Akt/mTOR pathway through multiple mechanisms, with inhibition of Akt and suppression of mTOR 1 activity being the main therapeutic approaches. Combination therapy has been shown to improve the efficacy of these inhibitors in suppressing prostate cancer progression or overcoming resistance by cancer cells.
Review
Biochemistry & Molecular Biology
Torki A. Zughaibi, Mohd Suhail, Mohammad Tarique, Shams Tabrez
Summary: Cancer is a leading cause of death globally, and current therapies often fail due to side effects, drug resistance, and limited accessibility. Studies have shown that flavonoids, found in herbal/plant sources, may act as complementary treatments for cancer patients with their broad biological properties and anticancer activity by affecting different signaling cascades.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Maria Sofia Basile, Eugenio Cavalli, James McCubrey, Jorge Hernandez-Bello, Jose Francisco Munoz-Valle, Paolo Fagone, Ferdinando Nicoletti
Summary: This review examines the involvement of the PI3K/Akt/mTOR pathway in COVID-19 and discusses the potential use of specific inhibitors of this pathway for treating the disease.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Marwa El-Sheikh, Ayman Mesalam, Atif Ali Khan Khalil, Muhammad Idrees, Mi-Jeong Ahn, Ahmed Atef Mesalam, Il-Keun Kong
Summary: In this study, we investigated the toxicity of juglone and its relationship with PI3K/AKT/mTOR signaling during the in vitro maturation (IVM) of oocytes. Results showed that juglone exposure led to a significant decrease in F-actin accumulation and downregulation of various genes related to oocyte development and meiosis progression. Juglone treatment also resulted in decreased expression of markers associated with glycolysis, ATP synthesis, OXPHOS, and oocyte survival, as well as lower expression of PI3K, AKT, and mTOR. Additionally, juglone-exposed oocytes exhibited increased expression of autophagy markers and DNA damage-specific markers.
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Oncology
Federica Rascio, Federica Spadaccino, Maria Teresa Rocchetti, Giuseppe Castellano, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri
Summary: The PI3K/Akt pathway plays a crucial role in drug resistance in cancer by impacting tumor cell growth and metastasis through different signaling pathways. Its multi-level deregulation contributes to resistance in various cancer types. Understanding the pathway is essential in developing potential inhibition strategies for overcoming drug resistance.
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso, Sajad Fakhri, Haroon Khan
Summary: As a major public health concern, neurological diseases and neurodegenerative diseases significantly impact the growing aging population, leading to disability and mortality. Apoptosis, inflammation, and oxidative stress play crucial roles in the development of neurodegenerative diseases, with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway being a key player. The blood-brain barrier poses challenges for drug delivery, but exosomes have emerged as potential nano-sized vehicles for central nervous system drug delivery due to their ability to cross the blood-brain barrier and their unique characteristics such as low immunogenicity and great tissue/cell penetration capabilities. This systematic review highlights the therapeutic potential of exosomes targeting the PI3K/Akt/mTOR signaling pathway in the context of neurodegenerative diseases and neurological diseases.
Review
Oncology
Qian Luo, Ruijuan Du, Wenting Liu, Guojing Huang, Zigang Dong, Xiang Li
Summary: Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer worldwide, mainly occurring in specific regions of Asia. The PI3K/Akt/mTOR signaling pathway plays a crucial role in regulating cell growth, differentiation, migration, metabolism, and proliferation, and is closely associated with survival and prognosis in ESCC patients. Many molecules can regulate this pathway and lead to its aberrant activation. Several effective inhibitors of the PI3K/Akt/mTOR pathway have been developed.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.