期刊
INTERNAL MEDICINE
卷 48, 期 4, 页码 203-208出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.48.1659
关键词
beta-tubulin; biomarker; docetaxel; drug resistance; immunohistochemistry; non-small-cell lung cancer
资金
- Promotion of Niigata University Research Projects to Hideyuki Kuriyama
- Ministry of Education, Science, and Culture of Japan
- Niigata University Grant
Objective To assess the relationship between in vitro chemosensitivity evaluated by the histoculture drug response assay (HDRA) and the expression of beta-tubulin isotypes in tumors of patients with completely resected NSCLC in order to determine the predictive value of beta-tubulin in chemotherapy for NSCLC. Methods Expression of beta-tubulin isotypes was immunohistochemically analyzed in a series of 58 tumor samples from patients with completely resected NSCLC. The sensitivity of individual tumors to anticancer agents was evaluated by HDRA. Results Class III beta-tubulin expression by tumor cells was significantly correlated with resistance to docetaxel (p=0.0250), but not related with resistance to gemcitabine. Patient characteristics (age, gender, histology, and stage) were not associated with class III beta-tubulin expression. Conclusion An abundance of class III beta-tubulin in tumor cells could be a biomarker for resistance to docetaxel in patients with completely resected NSCLC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据