The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or WZB-117 Inhibit the Viability of Highly Resistant Human Lung Cancer Cells

Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation

(2017) Juan Sebastian Yakisich et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres

(2017) Juan Sebastian Yakisich et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres

(2017) Vivek Kaushik et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

(2017) Amanda B. Parris et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides

(2017) Juan Sebastian Yakisich et al.   TUMOR BIOLOGY

Selective and Irreversible Induction of Necroptotic Cell Death in Lung Tumorspheres by Short-Term Exposure to Verapamil in Combination with Sorafenib

(2017) Juan Sebastian Yakisich et al.   Stem Cells International

Combination of 2-deoxy d -glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism

(2016) Xiao-bin Hou et al.   BIOMEDICINE & PHARMACOTHERAPY

Combinational strategies of metformin and chemotherapy in cancers

(2016) Hui-Hui Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase

(2016) QIANQIAN GUO et al.   Molecular Medicine Reports

The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development

(2016) Jun Gong et al.   Targeted Oncology

Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells

(2016) ZHIYUN YU et al.   Oncology Letters

Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis

(2016) Qiuli Liu et al.   Oncotarget

Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer

(2016) Kyung-Min Lee et al.   Oncotarget

Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model

(2016) Juan Sebastian Yakisich et al.   Stem Cells International

Bulk pancreatic cancer cells can convert into cancer stem cells(CSCs) in vitro and 2 compounds can target these CSCs

(2015) Xiaoyan Ning et al.   CELL CYCLE

Negative regulation of Bmi-1 by AMPK and implication in cancer progression

(2015) Deqiang Huang et al.   Oncotarget

Inhibitory effects of metformin at low concentration on epithelial–mesenchymal transition of CD44+CD117+ ovarian cancer stem cells

(2015) Rongrong Zhang et al.   Stem Cell Research & Therapy

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

(2015) Zhiguang Xiao et al.   Oncotarget

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Protective Effects of Sesaminol on BEAS-2B Cells Impaired by Cigarette Smoke Extract

(2014) Ping Dong et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

(2014) Audrey Mansuet-Lupo et al.   Journal of Translational Medicine

Interpreting the Consequences of Metformin Accumulation in an Emergency Context: Impact of the Time Frame on the Blood Metformin Levels

(2014) Jean-Daniel Lalau et al.   International Journal of Endocrinology

Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis

(2014) Deepika Neelakantan et al.   Cell Adhesion & Migration

Opportunities to address lung cancer disparities among African Americans

(2014) Steven S. Coughlin et al.   Cancer Medicine

Metformin accumulation: Lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy

(2013) S. Vecchio et al.   CLINICAL TOXICOLOGY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Multifunctional Role of Bcl-2 in Malignant Transformation and Tumorigenesis of Cr(VI)-Transformed Lung Cells

(2012) Djordje Medan et al.   PLoS One

Establishment of a Database of Metformin Plasma Concentrations and Erythrocyte Levels in Normal and Emergency Situations

(2011) Jean-Daniel Lalau et al.   CLINICAL DRUG INVESTIGATION

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

(2011) Qilong Wang et al.   PLoS One

Clonogenic Assay: Adherent Cells

(2011) Haloom Rafehi et al.   Jove-Journal of Visualized Experiments

Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound

(2010) Youcef M. Rustum et al.   Journal of Oncology

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

(2009) S. Saito et al.   CANCER RESEARCH

Identification of DDB2 Protein as a Transcriptional Regulator of ConstitutiveSOD2Gene Expression in Human Breast Cancer Cells

(2009) Vanessa Minig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY