Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors

Comparison of mechanistic transport cycle models of ABC exporters

(2018) Dániel Szöllősi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conformational Coupling and trans-Inhibition in the Human Antigen Transporter Ortholog TmrAB Resolved with Dipolar EPR Spectroscopy

(2018) Katja Barth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Confidence Analysis of DEER Data and Its Structural Interpretation with Ensemble-Biased Metadynamics

(2018) Eric J. Hustedt et al.   BIOPHYSICAL JOURNAL

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

(2017) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

(2017) Suneet Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

About P-glycoprotein: a new drugable domain is emerging from structural data

(2017) Ricardo J. Ferreira et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein

(2016) Eduardo E. Chufan et al.   BIOCHEMICAL PHARMACOLOGY

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation

(2014) Tip W. Loo et al.   BIOCHEMICAL PHARMACOLOGY

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

DEER Distance Measurements on Proteins

(2012) Gunnar Jeschke   Annual Review of Physical Chemistry

Snapshots of the maltose transporter during ATP hydrolysis

(2011) M. L. Oldham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy

(2011) Hassane S. Mchaourab et al.   STRUCTURE

Increased Sensitivity and Extended Range of Distance Measurements in Spin-Labeled Membrane Proteins: Q-Band Double Electron-Electron Resonance and Nanoscale Bilayers

(2010) Ping Zou et al.   BIOPHYSICAL JOURNAL

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotamer libraries of spin labelled cysteines for protein studies

(2010) Yevhen Polyhach et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels

(2009) Smriti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP Occlusion by P-Glycoprotein as a Surrogate Measure for Drug Coupling†

(2008) Gregory Tombline et al.   BIOCHEMISTRY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS