Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
出版年份 2014 全文链接
标题
Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
作者
关键词
ABCG2, ATP-binding cassette, BCRP, drug transport, transporter
出版物
AAPS Journal
Volume 17, Issue 1, Pages 65-82
出版商
American Association of Pharmaceutical Scientists (AAPS)
发表日期
2014-09-19
DOI
10.1208/s12248-014-9668-6
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia
- (2014) Luciene Terezina de Lima et al. MEDICAL ONCOLOGY
- Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1
- (2013) Chung-Pu Wu et al. BIOCHEMICAL PHARMACOLOGY
- Predicting substrates of the human breast cancer resistance protein using a support vector machine method
- (2013) Eszter Hazai et al. BMC BIOINFORMATICS
- Progesterone Negatively Regulates BCRP in Progesterone Receptor-Positive Human Breast Cancer Cells
- (2013) Xiaojuan Wu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Multidrug Resistance-Associated Protein 2 (MRP2/ABCC2) Haplotypes Significantly Affect the Pharmacokinetics of Tacrolimus in Kidney Transplant Recipients
- (2013) Ken Ogasawara et al. CLINICAL PHARMACOKINETICS
- Harmful effect of ERβ on BCRP-mediated drug resistance and cell proliferation in ERα/PR-negative breast cancer
- (2013) Weiwei Li et al. FEBS Journal
- Interindividual Variability in the Hepatic Expression of the Human Breast Cancer Resistance Protein (BCRP/ABCG2): Effect of Age, Sex, and Genotype
- (2013) Bhagwat Prasad et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Identification of Novel Breast Cancer Resistance Protein (BCRP) Inhibitors by Virtual Screening
- (2013) Yongmei Pan et al. MOLECULAR PHARMACEUTICS
- Effects of polymorphisms in ABCG2, SLCO1B1, SLC10A1 and CYP2C9/19 on plasma concentrations of rosuvastatin and lipid response in Chinese patients
- (2013) Hon-Kit Lee et al. PHARMACOGENOMICS
- Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
- (2013) Wang-Qing Chen et al. PLoS One
- Influence of enzyme and transporter polymorphisms on trough imatinib concentration and clinical response in chronic myeloid leukemia patients
- (2012) S. J. Seong et al. ANNALS OF ONCOLOGY
- CYP2C9*3(1075A>C), MDR1 G2677T/A and MDR1 C3435T are Determinants of Inter-subject Variability in Fluvastatin Pharmacokinetics in Healthy Chinese Volunteers
- (2012) Q. Zhou et al. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
- (2012) Karthika Natarajan et al. BIOCHEMICAL PHARMACOLOGY
- Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP
- (2012) Hiroyuki Kusuhara et al. BRITISH JOURNAL OF PHARMACOLOGY
- Impact of Genetic Variation in Breast Cancer Resistance Protein (BCRP/ABCG2) on Sunitinib Pharmacokinetics
- (2012) Tomoyuki Mizuno et al. Drug Metabolism and Pharmacokinetics
- Impact of ABCC2, ABCG2 and SLCO1B1 Polymorphisms on the Pharmacokinetics of Pitavastatin in Humans
- (2012) Eun Sil Oh et al. Drug Metabolism and Pharmacokinetics
- Influence of ABCC2, SLCO1B1, and ABCG2 Polymorphisms on the Pharmacokinetics of Olmesartan
- (2012) Choon O. Kim et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Quantitative Structure-Activity Relationship (QSAR) Analysis to Predict Drug-Drug Interactions of ABC Transporter ABCG2
- (2012) T. Ishikawa et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Protein structure prediction from sequence variation
- (2012) Debora S Marks et al. NATURE BIOTECHNOLOGY
- Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior
- (2012) Carole Saison et al. NATURE GENETICS
- Selective increase of two ABC drug efflux transporters at the blood–spinal cord barrier suggests induced pharmacoresistance in ALS
- (2012) Michael R. Jablonski et al. NEUROBIOLOGY OF DISEASE
- Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patients
- (2012) Sang Hyub Lee et al. PATHOLOGY INTERNATIONAL
- Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: fromin vitrodata to clinical study design
- (2012) Joseph W. Polli et al. XENOBIOTICA
- Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity
- (2011) Zhanglin Ni et al. BIOCHEMISTRY
- Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers
- (2011) Alicia J. Allred et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients
- (2011) Sin-Chi Chew et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Suspicion of Drug-Drug Interaction between High-Dose Methotrexate and Proton Pump Inhibitors: A Case Report – Should the Practice Be Changed?
- (2011) F. Ranchon et al. CHEMOTHERAPY
- ATP-Binding Cassette Efflux Transporters in Human Placenta
- (2011) Zhanglin Ni et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein
- (2011) L. Li et al. DRUG METABOLISM AND DISPOSITION
- Substituted Chromones as Highly Potent Nontoxic Inhibitors, Specific for the Breast Cancer Resistance Protein
- (2011) Glaucio Valdameri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Upregulation of ABCG2 by Romidepsin via the Aryl Hydrocarbon Receptor Pathway
- (2011) K. K. W. To et al. MOLECULAR CANCER RESEARCH
- The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers
- (2011) Akihiro Yamada et al. Pharmacogenetics and Genomics
- Dimerization of ABCG2 Analysed by Bimolecular Fluorescence Complementation
- (2011) Ameena J. Haider et al. PLoS One
- Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein
- (2011) Zsolt Bikadi et al. PLoS One
- Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport
- (2010) Zhanglin Ni et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Mutational Analysis of Threonine 402 Adjacent to the GXXXG Dimerization Motif in Transmembrane Segment 1 of ABCG2
- (2010) Orsolya Polgar et al. BIOCHEMISTRY
- hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion and side populations
- (2010) F Wang et al. BRITISH JOURNAL OF CANCER
- Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
- (2010) Zhanglin Ni et al. CURRENT DRUG METABOLISM
- Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level
- (2010) Kyoung-Ah Kim et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib
- (2010) Neeltje Steeghs et al. INVESTIGATIONAL NEW DRUGS
- Proinflammatory Cytokines Enhance Estrogen-dependent Expression of the Multidrug Transporter GeneABCG2through Estrogen Receptor and NFκB Cooperativity at Adjacent Response Elements
- (2010) Madhumita Pradhan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 17-β-Estradiol: A Powerful Modulator of Blood–Brain Barrier BCRP Activity
- (2010) Anika MS Hartz et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia
- (2010) Naoto Takahashi et al. JOURNAL OF HUMAN GENETICS
- Role of Basic Residues within or near the Predicted Transmembrane Helix 2 of the Human Breast Cancer Resistance Protein in Drug Transport
- (2010) X. Cai et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone
- (2010) H. Kodaira et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
- (2010) S. Agarwal et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Membrane transporters in drug development
- (2010) NATURE REVIEWS DRUG DISCOVERY
- Dynamic vs Static ABCG2 Inhibitors to Sensitize Drug Resistant Cancer Cells
- (2010) Hui Peng et al. PLoS One
- The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone
- (2010) Mark F. Rosenberg et al. STRUCTURE
- Structure–Activity Relationships and Quantitative Structure–Activity Relationships for Breast Cancer Resistance Protein (ABCG2)
- (2009) Yash A. Gandhi et al. AAPS Journal
- Differential Effects of Tipranavir plus Ritonavir on Atorvastatin or Rosuvastatin Pharmacokinetics in Healthy Volunteers
- (2009) P. A. Pham et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Effects of Putative Catalytic Base Mutation E211Q on ABCG2-Mediated Methotrexate Transport
- (2009) Yue-xian Hou et al. BIOCHEMISTRY
- Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties
- (2009) C Hegedűs et al. BRITISH JOURNAL OF PHARMACOLOGY
- ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin
- (2009) J E Keskitalo et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors
- (2009) Neeltje Steeghs et al. INVESTIGATIONAL NEW DRUGS
- Effects of Atazanavir/Ritonavir or Fosamprenavir/Ritonavir on the Pharmacokinetics of Rosuvastatin
- (2009) Anthony J Busti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar
- (2009) Matthias Kühnle et al. JOURNAL OF MEDICINAL CHEMISTRY
- ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides
- (2009) H. Xiong et al. JOURNAL OF NEUROSCIENCE
- Oral Sulfasalazine as a Clinical BCRP Probe Substrate: Pharmacokinetic Effects of Genetic Variation (C421A) and Pantoprazole Coadministration
- (2009) Kimberly K. Adkison et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2
- (2009) K. K.W. To et al. MOLECULAR CANCER THERAPEUTICS
- MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells
- (2009) Y.-Z. Pan et al. MOLECULAR PHARMACOLOGY
- Different effects of theABCG2c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin
- (2009) Jenni E Keskitalo et al. PHARMACOGENOMICS
- Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
- (2009) O. M. Woodward et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- QSAR analysis and molecular modeling of ABCG2-specific inhibitors
- (2008) E. Nicolle et al. ADVANCED DRUG DELIVERY REVIEWS
- Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice
- (2008) Maria L.H. Vlaming et al. ADVANCED DRUG DELIVERY REVIEWS
- Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells
- (2008) Mylène Honorat et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Membrane Topology of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Determined by Epitope Insertion and Immunofluorescence†
- (2008) Honggang Wang et al. BIOCHEMISTRY
- Breast Cancer Resistance Protein Expression and 5-Fluorouracil Resistance
- (2008) Jian-Hui YUAN et al. BIOMEDICAL AND ENVIRONMENTAL SCIENCES
- Structure–activity relationships of new inhibitors of breast cancer resistance protein (ABCG2)
- (2008) Anne Pick et al. BIOORGANIC & MEDICINAL CHEMISTRY
- TheABCG2C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects
- (2008) Kimberly K. Adkison et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
- (2008) Kunihiro Suzuki et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2
- (2008) C.-l. Dai et al. CANCER RESEARCH
- Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans
- (2008) Y Yamasaki et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N- -6-[5-( methyl)-2-furyl]-4-quinazolinamine; GW572016)
- (2008) J. W. Polli et al. DRUG METABOLISM AND DISPOSITION
- Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
- (2008) N. Giri et al. DRUG METABOLISM AND DISPOSITION
- Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
- (2008) S. Kitamura et al. DRUG METABOLISM AND DISPOSITION
- Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers
- (2008) Jennifer J Kiser et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Pharmacogenomic and Pharmacokinetic Determinants of Erlotinib Toxicity
- (2008) Charles M. Rudin et al. JOURNAL OF CLINICAL ONCOLOGY
- Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
- (2008) T. Watanabe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
- (2008) Shuji Ota et al. LUNG CANCER
- Regulation of ABCG2 Expression at the 3' Untranslated Region of Its mRNA through Modulation of Transcript Stability and Protein Translation by a Putative MicroRNA in the S1 Colon Cancer Cell Line
- (2008) K. K. W. To et al. MOLECULAR AND CELLULAR BIOLOGY
- Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe
- (2008) Bradley L. Urquhart et al. Pharmacogenetics and Genomics
- The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane
- (2007) M. Huls et al. KIDNEY INTERNATIONAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started