Review
Pharmacology & Pharmacy
Changwei Wang, Angelo Aguilar, Iwao Ojima
Summary: This review provides an overview of the latest research progress on the clinical applications of paclitaxel and docetaxel, including new formulations, the design and development of next-generation taxanes, and taxane-based drug delivery systems. The review emphasizes the importance of next-generation taxanes in eradicating cancer stem cells and overcoming multidrug resistance, and suggests exploring effective nanoformulations and tumor-targeted drug delivery systems.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Review
Pharmacology & Pharmacy
Yihui Song, Xiaoke Yang, Bin Yu
Summary: Drug repurposing is an attractive strategy for finding new indications for existing drugs. Three approved antidepressants have shown potential in clinical trials for cancer treatment. By conducting further medicinal chemistry research, several TCP-based inhibitors of the histone lysine specific demethylase 1 enzyme have been discovered, showing promise for cancer treatment. Repurposing antidepressants could be a promising strategy for cancer treatment.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Giovanni Graziano, Angela Stefanachi, Marialessandra Contino, Ruben Prieto-Diaz, Alessia Ligresti, Poulami Kumar, Antonio Scilimati, Eddy Sotelo, Francesco Leonetti
Summary: Multicomponent reactions (MCRs) are widely used in synthetic organic chemistry for drug discovery and development due to their flexibility in forming complex products with high efficiency. They are considered as an exploratory and evolutionary tool in medicinal chemistry, enabling sustainable and rapid synthesis of biologically active molecules. This review provides an overview of the approaches and applications of MCRs in the development of new anticancer drugs, showcasing their extensive use in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Organic
Pedro Alves Bezerra Morais, Carla Santana Francisco, Heberth de Paula, Rayssa Ribeiro, Mariana Alves Eloy, Clara Lirian Javarini, Alvaro Cunha Neto, Valdemar Lacerda Junior
Summary: Medicinal chemistry has historically focused on the approach of organic chemistry for new drug synthesis, with dedicated efforts resulting in fruitful collections of new molecular entities. Scientists' altruistic nature drives the planning and search for new and applicable pharmacologic therapies. Since the 19th century, the use of isolated and characterized plant-derived compounds in modern drug discovery and clinical development has highlighted its viability and significance.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Ridam Kapoor, Anamika Saini, Deepika Sharma
Summary: In recent years, there has been a growing focus on the development of naturally derived products for cancer treatment. Natural sources have provided a wide range of medicinal agents, many of which are used to treat various diseases including cancer. The search for effective novel drugs is crucial in cancer treatment due to the development of resistance to chemotherapy drugs and their high toxicity. Microbes, plants, fungi, and marine microorganisms have been explored as sources for chemotherapeutic drugs, with microbial diversity playing a significant role in pharmaceutical formulation. Microbe-derived anticancer drugs have shown promise as effective chemotherapeutic agents, and this review provides an overview of their derivatives, mechanisms of action, isolation procedures, limitations, and clinical study phases.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pan Pantziarka, Rica Capistrano, Arno De Potter, Liese Vandeborne, Gauthier Bouche
Summary: Currently, there is no global, unified listing of approved anticancer drugs, but a methodology exists to combine and cleanse relevant data from multiple sources to produce a database specifically for therapeutic antineoplastic purposes, which can be used by researchers as input for further research projects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Guang Huang, Tomasz Cierpicki, Jolanta Grembecka
Summary: Cancer is a leading cause of death and disease globally, and efforts have been made to develop new compounds with improved anticancer properties. 2-Aminobenzothiazole is a class of important heterocycles with various medical and pharmacological activities. Recent research has discovered potent and low-toxicity 2-aminobenzothiazole compounds as new anticancer agents. This article provides a comprehensive review of the activities, design strategies, mechanisms of action, and pre-clinical development of these compounds, highlighting their advantages over other heterocyclic systems.
BIOORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Li-Juan Deng, Wei-Qing Deng, Shu-Ran Fan, Min-Feng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, Amit K. Tiwari, Jia-Xu Chen, Dong-Mei Zhang, Zhe-Sheng Chen
Summary: Abnormal N6-methyladenosine (m6A) modification is closely related to cancer development, and finding targeted anticancer drugs is important. Traditional herbs and computer-synthesized compounds are reasonable sources for these drugs. Artificial intelligence has advantages in discovering m6A-targeting anticancer drugs.
Article
Chemistry, Medicinal
Jingxing Wu, Yi Xiao, Mujie Lin, Hanxuan Cai, Duancheng Zhao, Yirui Li, Hailin Luo, Chuanqi Tang, Ling Wang
Summary: In this study, a total of 832 classification models were constructed using the FP-GNN deep learning method, based on the collection of 485,900 compounds and their bioactivity records. These models showed considerable predictive performance, with the highest AUC values of 0.91, 0.88, and 0.91 for targets, academia-sourced cell lines, and NCI60 cancer cell lines, respectively. A user-friendly webserver called DeepCancerMap was developed based on these models, providing various functions for anticancer drug discovery.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Xing-Jie Dai, Lei-Peng Xue, Shi-Kun Ji, Ying Zhou, Ya Gao, Yi-Chao Zheng, Hui-Min Liu, Hong-Min Liu
Summary: In recent years, triazole-fused pyrimidines, a widely-used class of heterocycles in medicinal chemistry, have shown potential as anticancer agents that target various cancer-associated targets. This review focuses on the latest advancements in triazole-pyrimidines as target-based anticancer agents, published between 2007 and 2022. The review also discusses the structure-activity relationships (SARs) and multiple pathways to facilitate the development of more effective and biotargeted anticancer candidates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Vivek P. P. Chavda, Yavuz Nuri Ertas, Vinayak Walhekar, Dharti Modh, Avani Doshi, Nirav Shah, Krishna Anand, Mahesh Chhabria
Summary: Investigations into natural chemical compounds for their programmed necrosis potential have led to the emergence of multi-target drugs and new drug discovery methods like fragment-based drug discovery for natural anticancer agents.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Joachim Alexandre, Joe-Elie Salem, Javid Moslehi, Marion Sassier, Camille Ropert, Jennifer Cautela, Franck Thuny, Stephane Ederhy, Ariel Cohen, Ghandi Damaj, Jean-Pierre Vilque, Anne-Flore Plane, Damien Legallois, Laure Champ-Rigot, Paul Milliez, Christian Funck-Brentano, Charles Dolladille
Summary: The emergence of novel anticancer therapies has led to signals of cardiotoxicity, including atrial fibrillation (AF), but data on the liability of anticancer drugs in inducing AF are scarce. A study using the World Health Organization's individual case safety report database, VigiBase(R), identified 19 anticancer drugs significantly associated with AF, with further confirmation needed through dedicated prospective clinical trials. The findings suggest that anticancer drugs themselves could be independent risk factors for AF development, particularly in hematologic malignancies.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Ning Zhang, Cuicui Xie, Yale Jiang, Yunhe Qin, Liyun Zhou, Yi Fan, Lianjie Ren, Chen Yin, Huan Yang, Wei Xie, Qing Zhai, Guanqiao Li, Hongzhuan Chen, Xiaoyuan Chen
Summary: China has undergone a revolution in drug regulation over the past two decades, introducing significant changes to accelerate drug review and approvals. This study provides an overview of this revolution and analyzes the impact on the landscape of drug research and development through a comprehensive analysis of newly approved anticancer drugs in China. The innovative drug development in China has greatly benefited from pro-innovation policies and expedited program designations. The number of imported and domestic new anticancer drugs has significantly increased, and the drug lag has been dramatically shortened.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Nanoscience & Nanotechnology
Jin Qi, Ran Zhang, Xiaoming Liu, Yingyu Liu, Qingmei Zhang, Huaiyi Cheng, Ran Li, Lu Wang, Xiuping Wu, Bing Li
Summary: Carbon dots (CDs) have great potential in drug delivery, especially in the treatment of inflammatory, bacterial, and cancer diseases. CDs improve cellular uptake and absorption and have controlled release properties, enhancing the therapeutic effects. They also offer advantages such as high drug-loading, increased targeting, and reduced systemic side effects. However, the safety and toxicity of CDs need to be carefully evaluated before their clinical application.
ACS APPLIED NANO MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Flavia Anna Mercurio, Marian Vincenzi, Marilisa Leone
Summary: This review provides an overview of the structural and functional aspects of EphA2-Sam and its interactome. Peptide inhibitors that hinder Sam-Sam interactions could serve as anticancer therapeutics, but further research is needed to improve their affinity and validate their anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Murugan Kasi, K. Anandaraj, Ashraf A. Hatamleh, Fahad Saeed Albaqami, Saleh Al-Sohaibani
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2017)
Article
Chemistry, Applied
Judy Gopal, Vimala Anthonydhason, Manikandan Muthu, Enkhtaivan Gansukh, Somang Jung, Sechul Chul, Sivanesan Iyyakkannu
NATURAL PRODUCT RESEARCH
(2019)
Review
Chemistry, Analytical
Muthu Manikandan, Anbarasu Deenadayalan, A. Vimala, Judy Gopal, Sechul Chun
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Shanmugam Anusuya, Manish Kesherwani, K. Vishnu Priya, Antonydhason Vimala, Gnanendra Shanmugam, Devadasan Velmurugan, M. Michael Gromiha
CURRENT PROTEIN & PEPTIDE SCIENCE
(2018)
Review
Chemistry, Multidisciplinary
Sechul Chun, Manikandan Muthu, Judy Gopal, Diby Paul, Doo Hwan Kim, Enkhtaivan Gansukh, Vimala Anthonydhason
Article
Chemistry, Multidisciplinary
Se Chul Chun, Shang Xiaomin, Vimala Anthonydhason, Hyejin Jung, Shimels Tilahun Belachew, Judy Gopal, Diby Paul
APPLIED SCIENCES-BASEL
(2018)
Article
Public, Environmental & Occupational Health
Mysoon Al-Ansari, Noorah Alkubaisi, P. Vijayaragayan, K. Murugan
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2019)
Review
Biochemistry & Molecular Biology
Piby Paul, Vimala Antonydhason, Judy Gopal, Steve W. Haga, Nazim Hasan, Jae-Wook Oh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Engineering, Chemical
Jae-Wook Oh, Manikandan Muthu, Steve W. Haga, Vimala Anthonydhason, Piby Paul, Sechul Chun
Article
Biochemistry & Molecular Biology
Ezgi Uckun, Joachim T. Siaw, Jikui Guan, Vimala Anthonydhason, Johannes Fuchs, Georg Wolfstetter, Bengt Hallberg, Ruth H. Palmer
Summary: The study identified interacting proteins of ALK in NB cells and confirmed the ALK-SHP2 interaction, demonstrating that the interaction and SHP2-Y542 phosphorylation are dependent on ALK activation. Inhibition of SHP2 in ALK-driven NB cells resulted in inhibited cell growth, and there was a strong synergistic effect of combined ALK and SHP2 inhibition specific to ALK-driven NB cells, suggesting a potential therapeutic option.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Developmental Biology
Patricia Mendoza-Garcia, Swaraj Basu, Sanjay Kumar Sukumar, Badrul Arefin, Georg Wolfstetter, Vimala Anthonydhason, Linnea Molander, Ezgi Uckun, Henrik Lindehell, Cristina Lebrero-Fernandez, Jan Larsson, Erik Larsson, Mats Bemark, Ruth H. Palmer
Summary: This study identified some target genes of Alk, including Kah, which may play an important role in the regulation of embryonic midgut morphogenesis dependent on Alk signaling in Drosophila visceral muscle development.
Article
Biochemistry & Molecular Biology
Ezgi Uckun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Linnea Molander, Johannes Fuchs, Ruth H. Palmer
Summary: Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase with diverse functions in the central nervous system of Drosophila. By using BioID technology and CRISPR/Cas9, researchers identified molecules interacting with Alk and found that the next generation BioID proteins exhibit superior labeling speed and efficiency. LC-MS3-based screening revealed an extensive neuronal Alk proximitome and identified potential components of Alk signaling complexes.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sivasubbu Mangala Nagasundari, Kasi Murugan, Palanisamy Jeyakumar, Karuppiah Muthu
Summary: The study presents an ecofriendly and economically benign approach for synthesizing silver nanoparticles using Pedalium murex mucilage. The synthesized nanoparticles showed significant antibacterial, antioxidant, and photocatalytic activity, indicating potential for various applications.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Cell Biology
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Summary: This study investigated the relationship between ALK mutations and neuroblastoma using a fruit fly model. The researchers found that ALK mutations enhanced Alk signaling and caused hyperplasia by regulating apoptosis levels. Using single-cell RNA sequencing, they also identified the impact of ALK mutations on temporal fate specification in neuronal lineages.
DISEASE MODELS & MECHANISMS
(2022)
Article
Multidisciplinary Sciences
Senthilkumar Balakrishnan, Senbagam Duraisamy, Murugan Kasi, Selvam Kandasamy, Rajesh Sarkar, Anbarasu Kumarasamy