Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
出版年份 2018 全文链接
标题
Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
作者
关键词
-
出版物
Cell Death & Disease
Volume 9, Issue 2, Pages -
出版商
Springer Nature
发表日期
2018-01-26
DOI
10.1038/s41419-017-0132-2
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel
- (2016) Sayaka Sobue et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Selumetinib in the treatment of non-small-cell lung cancer
- (2016) Reyes Bernabé et al. Future Oncology
- SET protein overexpression contributes to paclitaxel resistance in MCF-7/S cells through PI3K/Akt pathway
- (2016) Weipeng Zhang et al. JOURNAL OF DRUG TARGETING
- The challenge of screening for early gastric cancer in China
- (2016) Liang Zong et al. LANCET
- Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform
- (2016) Y. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation
- (2016) Mark Borris D. Aldonza et al. Oncotarget
- Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – A critical role of Cdk1 in mitotic entry
- (2015) Wei-Ling Chang et al. BIOCHEMICAL PHARMACOLOGY
- Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules
- (2015) Yu Yu et al. CANCER CELL
- The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Targeting Drugs in Prostate Cancer
- (2015) Zhi Liu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs
- (2015) Youngmi Kim et al. MOLECULES AND CELLS
- Current treatment strategies for inhibiting mTOR in cancer
- (2015) Francesca Chiarini et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Combining Paclitaxel with ABT-263 Has a Synergistic Effect on Paclitaxel Resistant Prostate Cancer Cells
- (2015) Chihuei Wang et al. PLoS One
- Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells
- (2015) Mark Borris Docdoc Aldonza et al. PLoS One
- Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia
- (2015) Jacky Wong et al. Oncotarget
- Combination of microtubule associated protein-tau and β-tubulin III predicts chemosensitivity of paclitaxel in patients with advanced gastric cancer
- (2014) Jingwei Yu et al. EUROPEAN JOURNAL OF CANCER
- The Multicenter, Phase II Prospective Study of Paclitaxel Plus Capecitabine as First-Line Chemotherapy in Advanced Gastric Carcinoma
- (2014) J. Gong et al. ONCOLOGIST
- Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
- (2013) Ju-yeon Jeong et al. APOPTOSIS
- Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells
- (2013) Yunwei Ou et al. CANCER BIOLOGY & THERAPY
- Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy
- (2013) Serena Giovinazzi et al. CELL CYCLE
- A phase II study of triweekly paclitaxel and capecitabine combination therapy in patients with fluoropyrimidine-platinum-resistant metastatic gastric adenocarcinoma
- (2013) Lin Shen et al. Journal of Cancer Research and Therapeutics
- Management of gastric cancer in Asia: resource-stratified guidelines
- (2013) Lin Shen et al. LANCET ONCOLOGY
- Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
- (2012) Edita Aksamitiene et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer
- (2012) Jianan Shen et al. BIOMATERIALS
- Serum levels of TUBB3 correlate with clinical outcome in Chinese patients with advanced gastric cancer receiving first-line paclitaxel plus capecitabine
- (2012) Jingwei Yu et al. MEDICAL ONCOLOGY
- A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells
- (2011) Hong Qiu et al. CANCER LETTERS
- Expressions of thymidylate synthase, thymidine phosphorylase, class III β-tubulin, and excision repair cross-complementing group 1 predict response in advanced gastric cancer patients receiving capecitabine plus paclitaxel or cisplatin
- (2011) Ming Lu et al. Chinese Journal of Cancer Research
- mTOR as a therapeutic target in patients with gastric cancer
- (2011) Salah-Eddin Al-Batran et al. INTERNATIONAL JOURNAL OF CANCER
- Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters
- (2010) Y.-j. Mi et al. CANCER RESEARCH
- Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
- (2010) Margaret E Harley et al. EMBO JOURNAL
- Microtubule Dynamics, Mitotic Arrest, and Apoptosis: Drug-Induced Differential Effects of III-Tubulin
- (2010) P. P. Gan et al. MOLECULAR CANCER THERAPEUTICS
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
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