New development in the enantioselective synthesis of spiro compounds

N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate

(2017) Xiang-Yu Chen et al.   Chemical Science

Efficient construction of biologically important functionalized polycyclic spiro-fused carbocyclicoxindoles via an asymmetric organocatalytic quadruple-cascade reaction

(2017) Wen Ren et al.   RSC Advances

Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles

(2017) Ye Lin et al.   Organic Chemistry Frontiers

Squaramide-Catalyzed Enantioselective Cascade Approach to Bispirooxindoles with Multiple Stereocenters

(2016) Bo-Liang Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Construction of Highly Functionalized Spirobarbiturate-Cyclopentenes through Chiral Phosphine-Catalyzed [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Barbiturate-Derived Alkenes

(2016) Yang Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Chlorinative Dearomatization Reaction of Benzofurans

(2016) Xiao-Wei Liang et al.   ADVANCED SYNTHESIS & CATALYSIS

Diastereo- and Enantioselective Construction of Dihydroisocoumarin-Based Spirooxindole Frameworks via Organocatalytic Tandem Reactions

(2016) Jia-Le Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Regioselective Asymmetric Formal (3+2) Cycloadditions of Nitrone Ylides from Isatins and Enals

(2016) Yu-Rong Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores

(2016) Jijun Xue et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic [3+2] Cycloadditions of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles: Highly Diastereoselective and Enantioselective Synthesis of Dispirobarbiturates

(2016) Hong-Wu Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Spiro β-Lactamsviaa Squaramide- Catalyzed Sulfa-Michael Addition/Desymmetrization Protocol

(2016) Pankaj Chauhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

(2016) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzofulvenes in Trienamine Catalysis: Stereoselective Spiroindene Synthesis

(2016) Bjarke S. Donslund et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

(2016) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Organocatalytic Construction of Spiroindane Derivatives by Intramolecular Friedel-Crafts-Type 1,4-Addition

(2016) Keisuke Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Strategy for the Enantioselective Cycloaddition to Trisubstituted Nitroolefins to Create Spirocyclohexene-Oxetane Scaffolds

(2016) Alicia Monleón et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of C 1 - and C 2 -Symmetric Spirobiindanones through Counterion-Directed Enolate C -Acylation

(2016) Benjamin F. Rahemtulla et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst-Controlled Switch in Chemo- and Diastereoselectivities: Annulations of Morita-Baylis-Hillman Carbonates from Isatins

(2016) Gu Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition of 5H-thiazol-4-ones with N-itaconimides

(2016) Shuai Qiu et al.   Beilstein Journal of Organic Chemistry

Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence

(2016) Kun Zhao et al.   CHEMICAL COMMUNICATIONS

An asymmetric assembly of spirooxindole dihydropyranones through a direct enantioselective organocatalytic vinylogous aldol-cyclization cascade reaction of 3-alkylidene oxindoles with isatins

(2016) Jeng-Liang Han et al.   CHEMICAL COMMUNICATIONS

Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters

(2016) Bo-Liang Zhao et al.   CHEMICAL COMMUNICATIONS

Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones

(2016) Zhenhua Zhang et al.   CHEMICAL COMMUNICATIONS

Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C–H activation: unexpected inversion of the enantioselectivity induced by protic acids

(2016) Midori Nagamoto et al.   CHEMICAL COMMUNICATIONS

Enantioselective formation of cyclopropane spiroindenes from benzofulvenes by phase transfer catalysis

(2016) Bjarke S. Donslund et al.   CHEMICAL COMMUNICATIONS

The enantioselective construction of chiral spirooxindole-based 4-thiazolidinone via asymmetric catalytic formal [3+2] annulation using a bifunctional catalyst

(2016) Ping Cheng et al.   CHEMICAL COMMUNICATIONS

Asymmetric preparation of polysubstituted cyclopentanes by synergistic Pd(0)/amine catalyzed formal [3+2] cycloadditions of vinyl cyclopropanes with enals

(2016) Maxime Laugeois et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones

(2016) Zhen-Hua Wang et al.   CHEMICAL COMMUNICATIONS

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

(2016) Yue-Ming Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective Access to Spirocyclic Sultams by Chiral Cpx -Rhodium(III)-Catalyzed Annulations

(2016) Manh V. Pham et al.   CHEMISTRY-A EUROPEAN JOURNAL

Construction of Spirocyclic Oxindoles through Regio- and Stereoselective [3+2] or [3+2]/[4+2] Cascade Reaction of α,β-Unsaturated Imines with 3-Isothiocyanato Oxindole

(2016) Dan Du et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric, Three-Component, One-Pot Synthesis of Spiropyrazolones and 2,5-Chromenediones from Aldol Condensation/NHC-Catalyzed Annulation Reactions

(2016) Lei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Stereoselective [3+2] Cycloadditions of Chiral Palladium-ContainingN1-1,3-Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles

(2016) Tian-Ren Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synergistic Catalysis: Enantioselective Ring Expansion of Vinyl Cyclopropanes Combining Four Catalytic Cycles for the Synthesis of Highly Substituted Spirocyclopentanes Bearing up to Four Stereocenters

(2016) Marta Meazza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Cascade Reaction of α-Cyano Ketones and Isatylidene Malononitriles: Asymmetric Construction of Spiro[4H-pyran-oxindoles]

(2016) Jin Xie et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Synthesis of Spiro-Pyrrolidine-Pyr­azolones by Squaramide-Catalyzed Cascade Aza-Michael/Michael Reactions

(2016) Jun-Hua Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Nitroso Aldol Intramolecular Transesterification Cyclization Domino Reaction for Highly Effective Construction of Chiral Spirooxindoles

(2016) Shan-Ping Ji et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Spiro[indoline-3,2′-pyrroles] through N-Heterocyclic-Carbene-Catalyzed Formal [3+2] Annulation

(2016) Chengyuan Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles with Maleimides for the Efficient Construction of Pyrrolidonyl Spirooxindoles

(2016) Lei Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

(2016) G. Madhusudhan Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Construction of Spirocyclic Oxindoles via Tandem Michael/Michael Reactions Catalyzed by Multifunctional Quaternary Phosphonium Salt

(2016) Jiaxing Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin

(2016) Mattia Stucchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Construction of Tetrahydroquinolin-5-one-Based Spirooxindole Scaffold via an Organocatalytic Asymmetric Multicomponent [3 + 3] Cyclization

(2016) Qiu-Ning Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

1-Hydroxybenzotriazole-Assisted, N-Heterocyclic Carbene Catalyzed β-Functionalization of Saturated Carboxylic Esters: Access to Spirooxindole Lactones

(2016) Jianfeng Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic One-Pot Asymmetric Synthesis of Thiolated Spiro-γ-lactam Oxindoles Bearing Three Stereocenters

(2016) Xin Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective direct vinylogous aldol-cyclization cascade reaction between β,γ-unsaturated amides and o-quinones

(2016) Yu Jiang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2′-pyrrolidinyl bispirooxindoles

(2016) Satavisha Kayal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalyzed enantioselective Michael addition/cyclization cascade reaction of 3-isothiocyanato oxindoles with arylidene malonates

(2016) Raghunath Chowdhury et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalyzed [4 + 2] cyclization of α,β-unsaturated carboxylic acids bearing γ-H with isatins: an enantioselective synthesis of spirocyclic oxindole–dihydropyranones

(2016) Ling Zhu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction

(2016) Yongjian Chi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective synthesis of spirooxindole derivatives using an organocatalyzed tandem Michael–Michael reaction

(2016) Huicai Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives via an organocatalytic asymmetric Michael/cyclization cascade reaction

(2016) Jin Xie et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic asymmetric hetero-Diels–Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives

(2016) Hai-Lei Cui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalyzed [3 + 2] annulation of bromoenals with 3-aminooxindoles: highly enantioselective synthesis of spirocyclic oxindolo-γ-lactams

(2016) Kun-Quan Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diastereospecific and Enantioselective Access to Dispirooxindoles from Furfurylcyclobutanols by Means of a Pd-Catalyzed Arylative Dearomatization/Ring Expansion Cascade

(2016) Jianchao Liu et al.   ORGANIC LETTERS

Enantioselective Synthesis of Spirobarbiturate-Cyclohexenes through Phosphine-Catalyzed Asymmetric [4 + 2] Annulation of Barbiturate-Derived Alkenes with Allenoates

(2016) Honglei Liu et al.   ORGANIC LETTERS

Enantioselective Synthesis of Polysubstituted Spiro-nitroprolinates Mediated by a (R,R)-Me-DuPhos·AgF-Catalyzed 1,3-Dipolar Cycloaddition

(2016) Alberto Cayuelas et al.   ORGANIC LETTERS

Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of 1,6-Enynes with Cyclopropylideneacetamides

(2016) Soichi Yoshizaki et al.   ORGANIC LETTERS

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

(2016) Shengzheng Wang et al.   ORGANIC LETTERS

Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction

(2016) Luyi Zhu et al.   ORGANIC LETTERS

Chiral Aryliodine-Mediated Enantioselective Organocatalytic Spirocyclization: Synthesis of Spirofurooxindoles via Cascade Oxidative C–O and C–C Bond Formation

(2016) Yang Cao et al.   ORGANIC LETTERS

Asymmetric [3 + 2] Cycloaddition of Vinylcyclopropanes and α,β-Unsaturated Aldehydes by Synergistic Palladium and Organocatalysis

(2016) Kim Søholm Halskov et al.   ORGANIC LETTERS

α-Regioselective Asymmetric [3 + 2] Annulations of Morita–Baylis–Hillman Carbonates with Cyclic 1-Azadienes and Mechanism Elucidation

(2016) Kai-Kai Wang et al.   ORGANIC LETTERS

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

(2016) Nandarapu Kumarswamyreddy et al.   ORGANIC LETTERS

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

(2016) Jia-Xing Zhang et al.   ORGANIC LETTERS

PyBidine–Ni(OAc)2-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles

(2016) Takayoshi Arai et al.   ORGANIC LETTERS

Enantioselective synthesis of spirocyclic tetrahydrothiophene derivatives bearing a benzofuran-3(2H)-one scaffold. Unusual supramolecular crystal structure with high Z′

(2016) Dorota Kowalczyk et al.   TETRAHEDRON LETTERS

Organocatalytic asymmetric synthesis of trans -configured trispirooxindoles through a cascade Michael-cyclization reaction

(2016) Chaoling Wu et al.   TETRAHEDRON LETTERS

Nickel(ii)-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbene

(2016) Jing Guo et al.   Chemical Science

NHC-Catalyzed Enantioselective Dearomatizing Hydroacylation of Benzofurans and Benzothiophenes for the Synthesis of Spirocycles

(2016) Daniel Janssen-Müller et al.   ACS Catalysis

Stereoselective 1,6-Conjugate Addition/Annulation of para-Quinone Methides with Vinyl Epoxides/Cyclopropanes

(2016) Chao Ma et al.   ACS Catalysis

Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote γ-Carbon Addition of Enals with Isatins

(2016) Xianfeng Rong et al.   ACS Combinatorial Science

Enantioselective Synthesis of Spirooxindole Enols: Regioselective and Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Dibenzylidene Ketones

(2016) Dan Du et al.   ChemistryOpen

N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones

(2016) Wen-Qiang Jia et al.   Organic Chemistry Frontiers

Catalytic Asymmetric Dearomatization by Transition-Metal Catalysis: A Method for Transformations of Aromatic Compounds

(2016) Chao Zheng et al.   Chem

Organocatalytic Enantioselective Synthesis of Polysubstituted Spirooxindoles using a Tandem Michael-Michael Reaction

(2015) Santhi Abbaraju et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ-Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles

(2015) Tian-Ze Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused SpirooxindolesviaOrganocatalytic [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylides with Maleimides

(2015) Hong-Wu Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles

(2015) Lin-Jie Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Spirocyclic Oxindole-Fused Tetrahydrothiophenesvia N,N′-Dioxide-Nickel(II) Catalyzed Domino Reaction of 1,4-Dithiane-2,5-diol with 3-Alkenyloxindoles

(2015) Pengfei Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Cyclohexane-Fused Drug-Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic CentersviaOrganocatalytic Cascade Reactions

(2015) Bo Han et al.   ADVANCED SYNTHESIS & CATALYSIS

The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes withN-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5′-Trifluoromethyl-spiro[pyrrolidin-3,2′-oxindoles]

(2015) Quantao Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Spiroketals with Aminothiourea Catalysts

(2015) Naoki Yoneda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions

(2015) Chun-Xiang Zhuo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Construction of Spiroindolines with Three Contiguous Stereogenic Centers and Chiral Tryptamine Derivatives via Reactive Spiroindolenine Intermediates

(2015) Chun-Xiang Zhuo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enantioselective Synthesis of Spirobilactams through Copper-Catalyzed Intramolecular Double N-Arylation and Phase Separation

(2015) Jianguang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites

(2015) Qiang-Sheng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

(2015) Daniel Hack et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed [3+2+2] and [2+2+2] Cycloadditions of Two Alkynes with Cyclopropylideneacetamides

(2015) Tomoka Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed CH Functionalization and Spiroannulation

(2015) Suresh Reddy Chidipudi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles

(2015) Ming-Yue Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Spirocyclohexadienones by NHC-Catalyzed Formal [3+3] Annulation Reaction of Enals

(2015) Santhivardhana Reddy Yetra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds

(2015) Michael J. James et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic asymmetric construction of spiro[pyrrolidine-2,3′-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles

(2015) Guodong Zhu et al.   CHEMICAL COMMUNICATIONS

Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans

(2015) Youqiang Lin et al.   CHEMICAL COMMUNICATIONS

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

(2015) Wu-Lin Yang et al.   CHEMICAL COMMUNICATIONS

Asymmetric Kita spirolactonisation catalysed by anti-dimethanoanthracene-based iodoarenes

(2015) Stephen J. Murray et al.   CHEMICAL COMMUNICATIONS

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

(2015) Mingxia Ma et al.   CHEMICAL COMMUNICATIONS

Enantioselective Formal [3+3] Cycloadditions of Ketones and Cyclic 1-Azadienes by Cascade Enamine-Enamine Catalysis

(2015) Xiao-Long He et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Stereoselective [4+2] and [3+2] Spiroannulations of 2-(2-Oxoindolin-3-ylidene)acetic Esters Catalyzed by Bifunctional Thioureas

(2015) Magda Monari et al.   CHEMISTRY-A EUROPEAN JOURNAL

An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones

(2015) Yuanwei Xie et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Spirocyclic Indolenines

(2015) Michael J. James et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Iodine-Catalyzed Dearomatizative Spirocyclization for the Enantioselective Construction of an All-Carbon Stereogenic Center

(2015) Dong-Yang Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of Spiro[1,3-­indanedione-tetrahydrothiophene]s by ­Organocatalytic Sulfa-Michael/Michael Domino Reaction

(2015) Jindian Duan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Synthesis of Chiral Pyranonaphthoquinone-Fused Spirooxindoles through Organocatalytic Three-Component Cascade Reactions

(2015) Hong-Wu Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chiral Squaramide-Catalyzed Michael/­Alkylation Cascade Reaction for the Asymmetric Synthesis of Nitro-Spirocyclopropanes

(2015) Bo-Liang Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Brønsted Acid Catalyzed Asymmetric Diels–Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3′-oxindole] Framework

(2015) Yang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Assembly of Spirocyclic Oxindole-dihydropyranones through NHC-Catalyzed Cascade Reaction of Isatins with N-Hydroxybenzotriazole Esters of α,β-Unsaturated Carboxylic Acid

(2015) Yonglei Que et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams

(2015) Delu Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Optically Pure Spiro[cyclohexane-oxindoline] Derivatives via Catalytic Asymmetric Diels–Alder Reaction of Brassard-Type Diene with Methyleneindolines

(2015) Jianfeng Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams

(2015) Lin Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Construction of Polyfunctionalized Spiroannulated Dihydrothiophenes via a Formal Thio [3+2] Cyclization

(2015) Xue-Mei Zeng et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael/Friedel–Crafts Cascade Reaction of 3-Pyrrolyl-oxindoles and α,β-Unsaturated Aldehydes for the Construction of Chiral Spiro[5,6-dihydropyrido[1,2-a]pyrrole-3,3′-oxindoles]

(2015) Yong You et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Spirocyclopropane-Linked Heterocycles Containing Both Pyrazolones and Oxindoles through Michael/Alkylation Cascade Reactions

(2015) Jun-Hua Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective [4 + 1] Annulation Reactions of α-Substituted Ammonium Ylides To Construct Spirocyclic Oxindoles

(2015) Peng-Fei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Biaryls: Axial-to-Central Chirality Transfer

(2015) Liu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction

(2015) Jun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4]nonane-1,6-diones

(2015) Bin-Miao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles

(2015) Lulu Fan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters

(2015) Yong-Yuan Gui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Enantioselective Formal [4 + 2] Cycloaddition of Enones with Cyclic N-Sulfonylimines and Methylene Chromene for Chiral Spirocyclic Compounds

(2015) Jie Fei et al.   ORGANIC LETTERS

Zn-Catalyzed Diastereo- and Enantioselective Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

Organocatalytic Enantioselective 1,3-Dipolar Cycloadditions between Seyferth–Gilbert Reagent and Isatylidene Malononitriles: Synthesis of Chiral Spiro-phosphonylpyrazoline-oxindoles

(2015) Taiping Du et al.   ORGANIC LETTERS

Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

Catalytic Aldol–Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates

(2015) Satavisha Kayal et al.   ORGANIC LETTERS

Chiral Phosphine Oxide–Sc(OTf)3 Complex Catalyzed Enantioselective Bromoaminocyclization of 2-Benzofuranylmethyl N-Tosylcarbamates. Approach to a Novel Class of Optically Active Spiro Compounds

(2015) Zequan Li et al.   ORGANIC LETTERS

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

(2015) Wu-Lin Yang et al.   ORGANIC LETTERS

Highly Enantioselective [3 + 2]-Annulation of Isatin-Derived Morita–Baylis–Hillman Adducts with Cyclic Sulfonimines

(2015) Feng Wei et al.   ORGANIC LETTERS

Asymmetric Construction of Spiro[thiopyranoindole-benzoisothiazole] Scaffold via a Formal [3 + 3] Spiroannulation

(2015) Xiang Chen et al.   ORGANIC LETTERS

Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N-Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals

(2015) Danbo Xie et al.   ORGANIC LETTERS

Cooperative Chiral Guanidine/AgPF6 Catalyzed Asymmetric Isocyanoacetate Aldol Reaction with Isatins

(2015) Xiaohua Liu et al.   SYNLETT

Advances in dearomatization strategies of indoles

(2015) Stéphane P. Roche et al.   TETRAHEDRON

Organocatalytic synthesis of spirocyclohexane indane-1,3-diones via a chiral squaramide-catalyzed Michael/aldol cascade reaction of γ-nitro ketones and 2-arylideneindane-1,3-diones

(2015) Mamatha Amireddy et al.   TETRAHEDRON

Chiral phosphine-catalyzed tunable cycloaddition reactions of allenoates with benzofuranone-derived olefins for a highly regio-, diastereo- and enantioselective synthesis of spiro-benzofuranones

(2015) De Wang et al.   Chemical Science

Highly Enantioselective Control of Dynamic Cascade Transformations by Dual Catalysis: Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles

(2015) Samson Afewerki et al.   ACS Catalysis

Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael–Michael–aldol sequence

(2015) Qiang-Sheng Sun et al.   Organic Chemistry Frontiers

Enantioselective construction of spiro-1,3-indandiones with three stereocenters via organocatalytic Michael-aldol reaction of 2-arylideneindane-1,3-diones and nitro aldehydes

(2015) Jindian Duan et al.   Organic Chemistry Frontiers

Synthesis of Spiro[chroman/tetrahydrothiophene-3,3′-oxindole] ScaffoldsviaHeteroatom-Michael-Michael Reactions: Easily Controlled EnantioselectivityviaBifunctional Catalysts

(2014) Youming Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations

(2014) Luca Deiana et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine-Catalyzed Asymmetric Formal [4+2] Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles

(2014) Fang-Le Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Carboannulation with Allylsilanes

(2014) Nicolas R. Ball-Jones et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric [5+3] Formal Cycloadditions with Cyclic Enones through Cascade Dienamine-Dienamine Catalysis

(2014) Xiang Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro-Heterocycles

(2014) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Triple Relay Catalysis: Enantioselective Synthesis of Spirocyclic Indolines through a One-Pot Process Featuring an Asymmetric 6π Electrocyclization

(2014) Xiao-Ping Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Tamura Cycloadditions

(2014) Francesco Manoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Organocatalytic Direct C(sp2)H/C(sp3)H Oxidative Cross-Coupling by Chiral Iodine Reagents

(2014) Hua Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A catalytic asymmetric hetero-Diels–Alder reaction of olefinic azlactones and isatins: facile access to chiral spirooxindole dihydropyranones

(2014) Tai-Ping Gao et al.   CHEMICAL COMMUNICATIONS

An organocatalytic domino Michael-alkylation reaction: highly enantioselective construction of spiro-cyclopentanoneoxindoles and tetronic acid scaffolds

(2014) Jing Zhou et al.   CHEMICAL COMMUNICATIONS

Iron-catalysed asymmetric tandem spiro-cyclization using dioxygen in air as the hydrogen acceptor

(2014) Takuya Oguma et al.   CHEMICAL COMMUNICATIONS

Phosphine-catalyzed asymmetric [4+1] annulation of activated α,β-unsaturated ketones with Morita–Baylis–Hillman carbonates: enantioselective synthesis of spirooxindoles containing two adjacent quaternary stereocenters

(2014) Fang-Le Hu et al.   CHEMICAL COMMUNICATIONS

Direct enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole–dihydropyranones

(2014) Tian-Ze Li et al.   CHEMICAL COMMUNICATIONS

Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions

(2014) Wei Tan et al.   CHEMICAL COMMUNICATIONS

Highly Enantioselective [3+2] Cycloaddition of Vinylcyclopropane with Nitroalkenes Catalyzed by Palladium(0) with a Chiral Bis(tert-amine) Ligand

(2014) Feng Wei et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Construction of 3,3′-Spirooxindoles Fused with Seven-Membered Rings by Enantioselective Tandem Reactions

(2014) Yang Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Cascade Michael Addition/Cyclization Reactions of 3-Nitro-2H-Chromenes with 3-Isothiocyanato Oxindoles: Efficient Synthesis of Functionalized Polycyclic Spirooxindoles

(2014) Fen Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Organocatalytic Activation of Unmodified Morita-Baylis-Hillman Alcohols for the Synthesis of Bicyclic α-Alkylidene-Ketones

(2014) Julian Stiller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework

(2014) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereo- and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro-β-carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction

(2014) Wei Dai et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Pot Organocatalytic Enantioselective Michael/Povarov Domino Strategy for the Construction of Spirooctahydroacridine-3,3′-oxindole Scaffolds

(2014) Hao Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Facile Synthesis of Chiral Spirooxindole-Based Isotetronic Acids and 5-1H-Pyrrol-2-ones through Cascade Reactions with Bifunctional Organocatalysts

(2014) Wengang Guo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Tandem 1,5-Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines

(2014) Weidi Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Asymmetric Cascade Reactions of 7-Vinylindoles: Diastereo- and Enantioselective Synthesis of C7-Functionalized Indoles

(2014) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade for the Asymmetric Synthesis of Spirocyclic Tetrahydrothiophene Chromanone Derivatives

(2014) Bo-Liang Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Construction of Spirocyclopentaneoxindoles Containing Four Consecutive Stereocenters through an Organocatalytic Iminium-Enamine Cascade Reaction

(2014) Liang-Zhong Ding et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Michael Addition/Cyclization Cascade Reaction of 3-Isothiocyanatooxindoles with Nitro Olefins

(2014) Satavisha Kayal et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide

(2014) Jun-An Xiao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Spirooxindole α-exo-Methylene-γ-butyrolactones from 3-OBoc-Oxindoles

(2014) Samydurai Jayakumar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Spiro[isoxazolin-3,3′-oxindoles] via the Catalytic 1,3-Dipolar Cycloaddition Reaction of Nitrile Oxides

(2014) Xiangjin Lian et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Construction of Spiro[indoline-3,2′-pyrrole] Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions Using Allenes as Equivalents of Alkynes

(2014) Cong-Shuai Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes

(2014) Xiao-Fei Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirocyclic Oxindole–Dihydropyranones

(2014) Zhaoxin Xiao et al.   ORGANIC LETTERS

Streocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2-Addition Reactions

(2014) Pankaj Chauhan et al.   ORGANIC LETTERS

Palladium-Catalyzed Asymmetric Cycloadditions of Vinylcyclopropanes and in Situ Formed Unsaturated Imines: Construction of Structurally and Optically Enriched Spiroindolenines

(2014) Ze-Shui Liu et al.   ORGANIC LETTERS

Chiral Spirooxindole–Butenolide Synthesis through Asymmetric N-Heterocyclic Carbene-Catalyzed Formal (3 + 2) Annulation of 3-Bromoenals and Isatins

(2014) Chenguang Zheng et al.   ORGANIC LETTERS

Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ-Lactones

(2014) Shuai Zhao et al.   ORGANIC LETTERS

Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

(2014) Han-Ming Zhang et al.   ORGANIC LETTERS

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Cyclobutanes through Organocatalytic Formal [2 + 2] Cycloadditions under H-Bond-Directing Dienamine Activation

(2014) Liang-Wen Qi et al.   ORGANIC LETTERS

Asymmetric Synthesis of Spiro-epoxyoxindoles by the Catalytic Darzens Reaction of Isatins with Phenacyl Bromides

(2014) Yulong Kuang et al.   ORGANIC LETTERS

Organocatalytic asymmetric one-pot sequential reaction: synthesis of highly substituted spirocyclohexanepyrazolones with six contiguous stereogenic carbons

(2014) Ping Sun et al.   TETRAHEDRON

Organocatalytic [4+2] addition reactions via tetraenamine intermediate

(2014) Julian Stiller et al.   Chemical Science

Mechanism of Palladium/Amine Cocatalyzed Carbocyclization of Aldehydes with Alkynes and Its Merging with “Pd Oxidase Catalysis”

(2014) Stefano Santoro et al.   ACS Catalysis

Organocatalytic domino Michael/cyclization reaction: efficient synthesis of multi-functionalized tetracyclic spirooxindoles with multiple stereocenters

(2014) Zu-Kang Fu et al.   RSC Advances

Asymmetric Diels-Alder Reactions of 2,4,6-Trienals via Tetraenamine Catalysis

(2014) Qing-Qing Zhou et al.   Asian Journal of Organic Chemistry

Trienamine catalysis with linear deconjugated 3,5-dienones

(2014) Peng-Qiao Chen et al.   Organic Chemistry Frontiers

Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters

(2013) Dan Du et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Synthesis of Unsymmetrical Diaryl-Substituted Spirocyclohexanonepyrazolones through a Cascade [4+2] Double Michael Addition

(2013) Jin-Xin Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

CinchonaAlkaloid-Derived Thiourea-Catalyzed Diastereo- and Enantioselective [3+2] Cycloaddition Reaction of Isocyanoacetates to Isatins: A Facile Access to Optically Active Spirooxindole Oxazolines

(2013) Mei-Xin Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2′-pyrrole] Derivatives

(2013) Feng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine-Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2′,3′-Dihydro-1′H-spiro[indoline-3,4′-pyridin]-2-ones

(2013) Xiao-Nan Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones

(2013) Wangsheng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters

(2013) Yun-Lin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives

(2013) Xiaofei Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3′-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition

(2013) Long Wang et al.   CHEMICAL COMMUNICATIONS

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst

(2013) Qiao Chen et al.   CHEMICAL COMMUNICATIONS

Organocatalytic tandem Morita–Baylis–Hillman–Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold

(2013) Xiang Li et al.   CHEMICAL COMMUNICATIONS

Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades

(2013) Meiling Li et al.   CHEMICAL COMMUNICATIONS

Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita–Baylis–Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines

(2013) Neng-Jun Zhong et al.   CHEMICAL COMMUNICATIONS

Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

(2013) Kailong Zhu et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

(2013) Lara Cala et al.   CHEMICAL COMMUNICATIONS

Enantioselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N′-cyclic azomethine imines

(2013) Liang Hong et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

(2013) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric desymmetrization: efficient construction of spirocyclic oxindoles bearing a unique all-carbon quaternary stereogenic center via sulfa-Michael addition

(2013) Lu Yao et al.   CHEMICAL COMMUNICATIONS

An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles

(2013) Qi-Lin Wang et al.   CHEMICAL COMMUNICATIONS

α,β-Unsaturated Acyl Cyanides as New Bis-Electrophiles for Enantioselective Organocatalyzed Formal [3+3]Spiroannulation

(2013) Sébastien Goudedranche et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Synthesis of Spirocyclic Azlactones by a Double Michael-Addition Approach

(2013) Manuel Weber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Gold/Brønsted Acid Relay Catalysis for Enantioselective Construction of Spirocyclic Diketones

(2013) Deyun Qian et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Formal Hetero-Diels-Alder Reactions of Enones with Isatins to Give Spirooxindole Tetrahydropyranones

(2013) Hai-Lei Cui et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of Spirooxindoles: Asymmetric [3+2] Cycloaddition of (3-Isothiocyanato)oxindoles with Azodicarboxylates

(2013) Yu Jiang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Congested Spiro-cyclopentaneoxindoles via an Organocatalytic Cascade Reaction

(2013) Artur Noole et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Six-Membered Spirocyclic Oxindoles with Five Consecutive Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence

(2013) Bing Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine Species

(2013) Toshifumi Dohi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

(2013) Zhong-Yan Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Druglike Six-Membered Spirooxindoles through an Amino Enyne Catalysis

(2013) D. B. Ramachary et al.   ORGANIC LETTERS

Organocatalytic oxa/aza-Michael–Michael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3′-oxindole] Scaffolds

(2013) Haibin Mao et al.   ORGANIC LETTERS

Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center

(2013) Kang Liu et al.   ORGANIC LETTERS

Asymmetric Diels–Alder Reaction of 3-Olefinic Benzofuran-2-ones and Polyenals: Construction of Chiral Spirocyclic Benzofuran-2-ones

(2013) Xin Li et al.   ORGANIC LETTERS

Aminocatalytic Asymmetric exo-Diels–Alder Reaction with Methiodide Salts of Mannich Bases and 2,4-Dienals to Construct Chiral Spirocycles

(2013) Shan-Jun Zhang et al.   ORGANIC LETTERS

Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines

(2013) Qin Yin et al.   ORGANIC LETTERS

Highly Efficient and Stereocontrolled Construction of 3,3′-Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction

(2013) Xiong-Li Liu et al.   ORGANIC LETTERS

Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions of Disubstituted Ketenes for the Synthesis of β-Lactones and δ-Lactones

(2013) Xiaoyu Hao et al.   ORGANIC LETTERS

Direct Access to Enantioenriched Spiroacetals through Asymmetric Relay Catalytic Three-Component Reaction

(2013) Hua Wu et al.   ORGANIC LETTERS

Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

(2013) Xianjie Chen et al.   ORGANIC LETTERS

Asymmetric Construction of Spirocyclopentenebenzofuranone Core Structures via Highly Selective Phosphine-Catalyzed [3 + 2] Cycloaddition Reactions

(2013) Klaus Albertshofer et al.   ORGANIC LETTERS

Diastereo- and Enantioselective Construction of Oxindole-Fused Spirotetrahydrofuran Scaffolds through Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinyl Cyclopropanes and Isatins

(2013) Liang-yong Mei et al.   ORGANOMETALLICS

Enantioselective [3 + 2] annulation via C–H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

(2013) Takahiro Nishimura et al.   Chemical Science

Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies

(2013) Yongqiang Zhang et al.   ACS Combinatorial Science

Organocatalyzed aza-Michael–Michael cascade reactions to construct spirooxindole tetrahydroquinolines with all-carbon chiral centers

(2013) You-ming Huang et al.   RSC Advances

Heterocyclic Spiranes and Dispiranes via Enantioselective Phosphine-Catalyzed [3+2] Annulations

(2012) Deepti Duvvuru et al.   ADVANCED SYNTHESIS & CATALYSIS

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles

(2012) Li-Tao Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

(2012) Wenbin Wu et al.   CHEMICAL COMMUNICATIONS

Construction of adjacent spiro-quaternary and tertiary stereocenters through phosphine-catalyzed asymmetric [3+2] annulation of allenoates with alkylidene azlactones

(2012) De Wang et al.   CHEMICAL COMMUNICATIONS

An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Construction of Spirooxindole Derivatives through [3+2] Annulation Catalyzed by a Bisthiourea as a Multiple-Hydrogen-Bond Donor

(2012) Yan Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalyzed Cascade Reactions to Highly Functionalized Spirotetracyclic Indolenines and Oxindoles

(2012) Xiaoyu Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3′-oxindole]s

(2012) Atsuko Awata et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.

(2012) Artur Noole et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael-Cyclization Reaction

(2012) Hao Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

“Organo-Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′-Pyrrolidinyl Mono- and Bi-spirooxindole Frameworks

(2012) Yi-Ming Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Synthesis of Spiro[cyclohexanone-oxindoles] and Spiro[cyclohexanone-pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions

(2012) Bin Wu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita–Baylis–Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhos

(2012) Yan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Copper-Catalyzed Alkylation of β-Ketoesters and Subsequent Cyclization to Spirolactones/Bi-spirolactones

(2012) Qing-Hai Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Phosphoric Acid-Catalyzed Enantioselective and Diastereoselective Spiroketalizations

(2012) Zhankui Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Diastereo- and Enantioselective Formal [3 + 2]-Cycloadditions of Substituted Vinylcyclopropanes

(2012) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)/Brønsted Acid Catalyzed Enantioselective Allylic C–H Activation for the Synthesis of Spirocyclic Rings

(2012) Zhuo Chai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric spiroacetalization catalysed by confined Brønsted acids

(2012) Ilija Čorić et al.   NATURE

Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

(2012) Wen-Tao Wei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives

(2012) Jinyan Liang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes

(2012) Utpal Das et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines

(2012) Kun Jiang et al.   ORGANIC LETTERS

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

Rhodium-Catalyzed Asymmetric Formal Cycloadditions of Racemic Butadiene Monoxide with Imines

(2012) Zhaoqun Liu et al.   ORGANIC LETTERS

Enantioselective Gold-Catalyzed Synthesis of Polycyclic Indolines

(2012) Gianpiero Cera et al.   ORGANIC LETTERS

A Highly Diastereo- and Enantioselective Hg(II)-Catalyzed Cyclopropanation of Diazooxindoles and Alkenes

(2012) Zhong-Yan Cao et al.   ORGANIC LETTERS

A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

(2012) Feng Shi et al.   ORGANIC LETTERS

Dinuclear Zinc Catalyzed Asymmetric Spirannulation Reaction: An Umpolung Strategy for Formation of α-Alkylated-α-Hydroxyoxindoles

(2012) Barry M. Trost et al.   ORGANIC LETTERS

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

Palladium-Catalyzed Diastereo- and Enantioselective Synthesis of Substituted Cyclopentanes through a Dynamic Kinetic Asymmetric Formal [3+2]-Cycloaddition of Vinyl Cyclopropanes and Alkylidene Azlactones

(2011) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Aromatic Spiroketals by SpinPhox/Iridium(I)-Catalyzed Hydrogenation and Spiroketalization of α,α′-Bis(2-hydroxyarylidene) Ketones

(2011) Xiaoming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective methodologies for the synthesis of spiro compounds

(2011) Ramon Rios   CHEMICAL SOCIETY REVIEWS

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric dearomatization of pyrrolesviaIr-catalyzed allylic substitution reaction: enantioselective synthesis of spiro-2H-pyrroles

(2011) Chun-Xiang Zhuo et al.   Chemical Science

Organocatalytic enantioselective methodologies using Morita–Baylis–Hillman carbonates and acetates

(2011) Ramon Rios   Catalysis Science & Technology