Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles

(2011) Jie Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Binaphthol-Derived Bisphosphoric Acids Serve as Efficient Organocatalysts for Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides to Electron-Deficient Olefins

(2011) Long He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclicortho-Quinodimethanes

(2011) Yankai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru-Catalyzed Cross-Metathesis/Double Michael Addition Sequence

(2011) Ying-Mei Li et al.   ORGANIC LETTERS

Tertiary Amine-Catalyzed Chemoselective and Asymmetric [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates of Isatins with Propargyl Sulfones

(2011) Jing Peng et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

(2010) Mohamed Ashraf Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

(2010) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide

(2010) Arumugam Thangamani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation

(2010) Pitchaimani Prasanna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations

(2010) Masahiro Terada   SYNTHESIS-STUTTGART

A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents

(2009) Subramanian Vedhanarayanan Karthikeyan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asymmetric Iminium Ion Catalysis with a Novel Bifunctional Primary Amine Thiourea: Controlling Adjacent Quaternary and Tertiary Stereocenters

(2009) Patrizia Galzerano et al.   CHEMISTRY-A EUROPEAN JOURNAL

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines

(2009) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cu-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phenylsulfonyl Enones. Ligand Controlled Diastereoselectivity Reversal

(2009) Rocío Robles-Machín et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiourea-Catalyzed Highly Enantio- and Diastereoselective Additions of Oxindoles to Nitroolefins: Application to the Formal Synthesis of (+)-Physostigmine

(2009) Tommy Bui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Catalytic 1,3-Dipolar Cycloaddition Involving 2,3-Allenoate Dipolarophiles

(2009) Jie Yu et al.   ORGANIC LETTERS

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binaphthol-derived phosphoric acid as a versatile catalyst for enantioselective carbon–carbon bond forming reactions

(2008) Masahiro Terada   CHEMICAL COMMUNICATIONS

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Reaction Control in the Organocatalytic Asymmetric One-Pot, Three-Component Reaction of Aldehydes, Diethyl α-Aminomalonate and Nitroalkenes: Toward Diversity-Oriented Synthesis

(2008) Yan-Kai Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention

(2008) Raju Ranjith Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides Catalyzed by Copper(I)/TF-BiphamPhos Complexes

(2008) Chun-Jiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Catalytic Asymmetric 1,4-Addition and [3 + 2] Cycloaddition Reactions Using Chiral Calcium Complexes

(2008) Tetsu Tsubogo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole

(2008) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Calcium-Catalyzed Diastereo- and Enantioselective 1,4-Addition of Glycine Derivatives to α,β-Unsaturated Esters

(2008) Shū Kobayashi et al.   ORGANIC LETTERS

A facile and efficient synthesis of highly functionalised 3,3′-dispiropyrrolidine- and 3,3′-dispiropyrrolizidine bisoxindoles via [3+2] cycloaddition

(2008) Ponnusamy Shanmugam et al.   TETRAHEDRON LETTERS