One-Pot Organocatalytic Enantioselective Michael/Povarov Domino Strategy for the Construction of Spirooctahydroacridine-3,3′-oxindole Scaffolds

Vinylogous Organocatalytic Triple Cascade Reaction: Forging Six Stereocenters in Complex Spiro-Oxindolic Cyclohexanes

(2013) Indranil Chatterjee et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters

(2013) Dan Du et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Vinylogous Michael Addition/Cyclization Cascade Reaction for the Construction of Diversely Structured Spiro- Oxindole Skeletons

(2013) Xiao-Mei Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

Complex Bioactive Alkaloid-Type Polycycles through Efficient Catalytic Asymmetric Multicomponent Aza-Diels-Alder Reaction of Indoles with Oxetane as Directing Group

(2013) Zhilong Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones

(2013) Wangsheng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of Remote Stereochemistry in the Synthesis of Spirocyclic Oxindoles: Vinylogous Organocascade Catalysis

(2013) Xu Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals

(2013) Mattia Silvi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Asymmetric Diels-Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles

(2013) Guilong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives

(2013) Xiaofei Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Recent Developments in Catalytic Asymmetric Inverse-Electron-Demand Diels–Alder Reaction

(2013) Xianxing Jiang et al.   CHEMICAL REVIEWS

Synthesis of Six-Membered Spirocyclic Oxindoles with Five Consecutive Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence

(2013) Bing Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic oxa/aza-Michael–Michael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3′-oxindole] Scaffolds

(2013) Haibin Mao et al.   ORGANIC LETTERS

Anhydrides as α,β-unsaturated acyl ammonium precursors: isothiourea-promoted catalytic asymmetric annulation processes

(2013) Emily R. T. Robinson et al.   Chemical Science

Development of Cascade Reactions for the Concise Construction of Diverse Heterocyclic Architectures

(2012) Liang-Qiu Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton

(2012) Zhifeng Mao et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

(2012) Hervé Clavier et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles

(2012) Li-Tao Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic highly enantioselective vinylogous Povarov reaction

(2012) Lorenzo Caruana et al.   CHEMICAL COMMUNICATIONS

Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol

(2012) Charles M. Marson   CHEMICAL SOCIETY REVIEWS

Catalytic enantioselective [4 + 2]-cycloaddition: a strategy to access aza-hexacycles

(2012) Géraldine Masson et al.   CHEMICAL SOCIETY REVIEWS

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Cyclic Enethioureas as Dienophiles: Stereocontrolled Access to Enantioenriched Hexahydropyrroloquinolines

(2012) Guillaume Dagousset et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael-Cyclization Reaction

(2012) Hao Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Asymmetric Organocatalytic Povarov Reaction with 2-Hydroxystyrenes

(2012) Feng Shi et al.   JOURNAL OF ORGANIC CHEMISTRY

FeCl3-Catalyzed Stereoselective Construction of Spirooxindole Tetrahydroquinolines via Tandem 1,5-Hydride Transfer/Ring Closure

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

(2012) Feng Shi et al.   ORGANIC LETTERS

Highly enantioselective [4 + 2] annulations catalyzed by amino acid-based phosphines: Synthesis of functionalized cyclohexenes and 3-spirocyclohexene-2-oxindoles

(2012) Fangrui Zhong et al.   Chemical Science

Highly enantioselective three-component Povarov reaction catalyzed by SPINOL-phosphoric acids

(2012) Dan Huang et al.   RSC Advances

The Diarylprolinol Silyl Ether System: A General Organocatalyst

(2011) Kim L. Jensen et al.   ACCOUNTS OF CHEMICAL RESEARCH

An Asymmetric Organocatalytic One-Pot Strategy to Octahydroacridines

(2011) Gustav Dickmeiss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric [3+2] Annulation of Allylsilanes with Isatins: Synthesis of Spirooxindoles

(2011) Nadine V. Hanhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dioxindole in Asymmetric Catalytic Synthesis: Routes to Enantioenriched 3-Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A

(2011) Giulia Bergonzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective methodologies for the synthesis of spiro compounds

(2011) Ramon Rios   CHEMICAL SOCIETY REVIEWS

Asymmetric Synthesis of Tetrahydroquinolines with Quaternary Stereocenters through the Povarov Reaction

(2011) Mingsheng Xie et al.   CHEMISTRY-A EUROPEAN JOURNAL

Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles

(2011) Bin Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity

(2011) Florence Wong et al.   GUT

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Enecarbamates as Dienophiles: Highly Diastereo- and Enantioselective Synthesis of Substituted 4-Aminotetrahydroquinolines

(2011) Guillaume Dagousset et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Hydrogen-Bonding Catalysis of the Diels–Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeletons

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclicortho-Quinodimethanes

(2011) Yankai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Organocatalytic Synthesis of Complex Cyclopenta[b]quinoline Derivatives

(2011) Kim L. Jensen et al.   ORGANIC LETTERS

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Asymmetric Three-Component Inverse Electron-Demand Aza-Diels-Alder Reaction: Efficient Synthesis of Ring-Fused Tetrahydroquinolines

(2010) Mingsheng Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

(2010) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

(2010) Kun Jiang et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Asymmetric Cooperative Catalysis of Strong Bronsted Acid-Promoted Reactions Using Chiral Ureas

(2010) H. Xu et al.   SCIENCE

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

The Proline-Catalyzed Double Mannich Reaction of Acetaldehyde withN-Boc Imines

(2009) Carley Chandler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric Povarov reactions with 2- and 3-vinylindoles

(2009) Giulia Bergonzini et al.   CHEMICAL COMMUNICATIONS

The art of total synthesis through cascade reactions

(2009) K. C. Nicolaou et al.   CHEMICAL SOCIETY REVIEWS

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chiral Brønsted Acid-Catalyzed Enantioselective Three-Component Povarov Reaction

(2009) Hua Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Organocatalytic Enantioselective Aminosulfenylation of α,β-Unsaturated Aldehydes

(2008) Gui-Ling Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Organocatalysis: From Infancy to Adolescence

(2008) Alessandro Dondoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of satavaptan, a selective vasopressin V2receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial

(2008) Pere Ginès et al.   HEPATOLOGY

Three-Component Ag-Catalyzed Enantioselective Vinylogous Mannich and Aza-Diels−Alder Reactions with Alkyl-Substituted Aldehydes

(2008) Hiroki Mandai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines

(2008) Xinhong Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids

(2008) Vladimir V. Kouznetsov   TETRAHEDRON