标题
New development in the enantioselective synthesis of spiro compounds
作者
关键词
-
出版物
CHEMICAL SOCIETY REVIEWS
Volume -, Issue -, Pages -
出版商
Royal Society of Chemistry (RSC)
发表日期
2018-06-28
DOI
10.1039/c6cs00825a
参考文献
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- Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4]nonane-1,6-diones
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- Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles
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- A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters
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- Organocatalytic Enantioselective Formal [4 + 2] Cycloaddition of Enones with Cyclic N-Sulfonylimines and Methylene Chromene for Chiral Spirocyclic Compounds
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- Zn-Catalyzed Diastereo- and Enantioselective Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles
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- Organocatalytic Enantioselective 1,3-Dipolar Cycloadditions between Seyferth–Gilbert Reagent and Isatylidene Malononitriles: Synthesis of Chiral Spiro-phosphonylpyrazoline-oxindoles
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- Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles
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- Catalytic Aldol–Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates
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- Chiral Phosphine Oxide–Sc(OTf)3 Complex Catalyzed Enantioselective Bromoaminocyclization of 2-Benzofuranylmethyl N-Tosylcarbamates. Approach to a Novel Class of Optically Active Spiro Compounds
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- Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones
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- Highly Enantioselective [3 + 2]-Annulation of Isatin-Derived Morita–Baylis–Hillman Adducts with Cyclic Sulfonimines
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- Asymmetric Construction of Spiro[thiopyranoindole-benzoisothiazole] Scaffold via a Formal [3 + 3] Spiroannulation
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- Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N-Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals
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- Cooperative Chiral Guanidine/AgPF6 Catalyzed Asymmetric Isocyanoacetate Aldol Reaction with Isatins
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- Advances in dearomatization strategies of indoles
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- Organocatalytic synthesis of spirocyclohexane indane-1,3-diones via a chiral squaramide-catalyzed Michael/aldol cascade reaction of γ-nitro ketones and 2-arylideneindane-1,3-diones
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- Chiral phosphine-catalyzed tunable cycloaddition reactions of allenoates with benzofuranone-derived olefins for a highly regio-, diastereo- and enantioselective synthesis of spiro-benzofuranones
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- Highly Enantioselective Control of Dynamic Cascade Transformations by Dual Catalysis: Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles
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- Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael–Michael–aldol sequence
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- Enantioselective construction of spiro-1,3-indandiones with three stereocenters via organocatalytic Michael-aldol reaction of 2-arylideneindane-1,3-diones and nitro aldehydes
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- Synthesis of Spiro[chroman/tetrahydrothiophene-3,3′-oxindole] ScaffoldsviaHeteroatom-Michael-Michael Reactions: Easily Controlled EnantioselectivityviaBifunctional Catalysts
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- Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations
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- Phosphine-Catalyzed Asymmetric Formal [4+2] Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles
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- Catalytic Enantioselective Carboannulation with Allylsilanes
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- Asymmetric [5+3] Formal Cycloadditions with Cyclic Enones through Cascade Dienamine-Dienamine Catalysis
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- N-Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro-Heterocycles
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- Asymmetric Triple Relay Catalysis: Enantioselective Synthesis of Spirocyclic Indolines through a One-Pot Process Featuring an Asymmetric 6π Electrocyclization
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- Catalytic Asymmetric Tamura Cycloadditions
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- Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters
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- Asymmetric Organocatalytic Direct C(sp2)H/C(sp3)H Oxidative Cross-Coupling by Chiral Iodine Reagents
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- The use of spirocyclic scaffolds in drug discovery
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- A catalytic asymmetric hetero-Diels–Alder reaction of olefinic azlactones and isatins: facile access to chiral spirooxindole dihydropyranones
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- An organocatalytic domino Michael-alkylation reaction: highly enantioselective construction of spiro-cyclopentanoneoxindoles and tetronic acid scaffolds
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- Iron-catalysed asymmetric tandem spiro-cyclization using dioxygen in air as the hydrogen acceptor
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- Phosphine-catalyzed asymmetric [4+1] annulation of activated α,β-unsaturated ketones with Morita–Baylis–Hillman carbonates: enantioselective synthesis of spirooxindoles containing two adjacent quaternary stereocenters
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- Direct enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole–dihydropyranones
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- Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions
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- Highly Enantioselective [3+2] Cycloaddition of Vinylcyclopropane with Nitroalkenes Catalyzed by Palladium(0) with a Chiral Bis(tert-amine) Ligand
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- Catalytic Asymmetric Construction of 3,3′-Spirooxindoles Fused with Seven-Membered Rings by Enantioselective Tandem Reactions
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- Enantioselective Cascade Michael Addition/Cyclization Reactions of 3-Nitro-2H-Chromenes with 3-Isothiocyanato Oxindoles: Efficient Synthesis of Functionalized Polycyclic Spirooxindoles
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- Novel Organocatalytic Activation of Unmodified Morita-Baylis-Hillman Alcohols for the Synthesis of Bicyclic α-Alkylidene-Ketones
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- Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework
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- Diastereo- and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro-β-carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction
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- One-Pot Organocatalytic Enantioselective Michael/Povarov Domino Strategy for the Construction of Spirooctahydroacridine-3,3′-oxindole Scaffolds
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- Facile Synthesis of Chiral Spirooxindole-Based Isotetronic Acids and 5-1H-Pyrrol-2-ones through Cascade Reactions with Bifunctional Organocatalysts
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- Asymmetric Tandem 1,5-Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines
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- Organocatalytic Asymmetric Cascade Reactions of 7-Vinylindoles: Diastereo- and Enantioselective Synthesis of C7-Functionalized Indoles
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- Chiral Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade for the Asymmetric Synthesis of Spirocyclic Tetrahydrothiophene Chromanone Derivatives
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- Highly Enantioselective Construction of Spirocyclopentaneoxindoles Containing Four Consecutive Stereocenters through an Organocatalytic Iminium-Enamine Cascade Reaction
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- Catalytic Asymmetric Michael Addition/Cyclization Cascade Reaction of 3-Isothiocyanatooxindoles with Nitro Olefins
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- Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide
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- Enantioselective Synthesis of Spirooxindole α-exo-Methylene-γ-butyrolactones from 3-OBoc-Oxindoles
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- Asymmetric Synthesis of Spiro[isoxazolin-3,3′-oxindoles] via the Catalytic 1,3-Dipolar Cycloaddition Reaction of Nitrile Oxides
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- Enantioselective Construction of Spiro[indoline-3,2′-pyrrole] Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions Using Allenes as Equivalents of Alkynes
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- Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes
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- N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirocyclic Oxindole–Dihydropyranones
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- Streocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2-Addition Reactions
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- Palladium-Catalyzed Asymmetric Cycloadditions of Vinylcyclopropanes and in Situ Formed Unsaturated Imines: Construction of Structurally and Optically Enriched Spiroindolenines
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- Chiral Spirooxindole–Butenolide Synthesis through Asymmetric N-Heterocyclic Carbene-Catalyzed Formal (3 + 2) Annulation of 3-Bromoenals and Isatins
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- Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ-Lactones
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- Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams
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- An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters
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- Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Cyclobutanes through Organocatalytic Formal [2 + 2] Cycloadditions under H-Bond-Directing Dienamine Activation
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- Asymmetric Synthesis of Spiro-epoxyoxindoles by the Catalytic Darzens Reaction of Isatins with Phenacyl Bromides
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- Organocatalytic asymmetric one-pot sequential reaction: synthesis of highly substituted spirocyclohexanepyrazolones with six contiguous stereogenic carbons
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- Organocatalytic [4+2] addition reactions via tetraenamine intermediate
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- Mechanism of Palladium/Amine Cocatalyzed Carbocyclization of Aldehydes with Alkynes and Its Merging with “Pd Oxidase Catalysis”
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- Organocatalytic domino Michael/cyclization reaction: efficient synthesis of multi-functionalized tetracyclic spirooxindoles with multiple stereocenters
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- Asymmetric Diels-Alder Reactions of 2,4,6-Trienals via Tetraenamine Catalysis
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- Trienamine catalysis with linear deconjugated 3,5-dienones
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- Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters
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- Enantioselective Synthesis of Unsymmetrical Diaryl-Substituted Spirocyclohexanonepyrazolones through a Cascade [4+2] Double Michael Addition
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- CinchonaAlkaloid-Derived Thiourea-Catalyzed Diastereo- and Enantioselective [3+2] Cycloaddition Reaction of Isocyanoacetates to Isatins: A Facile Access to Optically Active Spirooxindole Oxazolines
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- Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2′-pyrrole] Derivatives
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- Phosphine-Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2′,3′-Dihydro-1′H-spiro[indoline-3,4′-pyridin]-2-ones
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- Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones
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- One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters
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- A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives
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- Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3′-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition
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- Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines
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- An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst
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- Organocatalytic tandem Morita–Baylis–Hillman–Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold
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- Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades
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- Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita–Baylis–Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines
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- Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives
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- Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives
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- A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals
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- Enantioselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N′-cyclic azomethine imines
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- Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
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- Organocatalytic asymmetric desymmetrization: efficient construction of spirocyclic oxindoles bearing a unique all-carbon quaternary stereogenic center via sulfa-Michael addition
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- An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles
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- α,β-Unsaturated Acyl Cyanides as New Bis-Electrophiles for Enantioselective Organocatalyzed Formal [3+3]Spiroannulation
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- Catalytic Asymmetric Synthesis of Spirocyclic Azlactones by a Double Michael-Addition Approach
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- Gold/Brønsted Acid Relay Catalysis for Enantioselective Construction of Spirocyclic Diketones
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- Catalytic Enantioselective Formal Hetero-Diels-Alder Reactions of Enones with Isatins to Give Spirooxindole Tetrahydropyranones
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- Enantioselective Synthesis of Spirooxindoles: Asymmetric [3+2] Cycloaddition of (3-Isothiocyanato)oxindoles with Azodicarboxylates
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- Asymmetric Synthesis of Congested Spiro-cyclopentaneoxindoles via an Organocatalytic Cascade Reaction
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- Synthesis of Six-Membered Spirocyclic Oxindoles with Five Consecutive Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence
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- Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine Species
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- Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex
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- Asymmetric Synthesis of Druglike Six-Membered Spirooxindoles through an Amino Enyne Catalysis
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- Organocatalytic oxa/aza-Michael–Michael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3′-oxindole] Scaffolds
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- Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center
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- Asymmetric Diels–Alder Reaction of 3-Olefinic Benzofuran-2-ones and Polyenals: Construction of Chiral Spirocyclic Benzofuran-2-ones
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- Aminocatalytic Asymmetric exo-Diels–Alder Reaction with Methiodide Salts of Mannich Bases and 2,4-Dienals to Construct Chiral Spirocycles
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- Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines
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- Highly Efficient and Stereocontrolled Construction of 3,3′-Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction
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- Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions of Disubstituted Ketenes for the Synthesis of β-Lactones and δ-Lactones
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- Direct Access to Enantioenriched Spiroacetals through Asymmetric Relay Catalytic Three-Component Reaction
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- Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives
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- Asymmetric Construction of Spirocyclopentenebenzofuranone Core Structures via Highly Selective Phosphine-Catalyzed [3 + 2] Cycloaddition Reactions
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- Diastereo- and Enantioselective Construction of Oxindole-Fused Spirotetrahydrofuran Scaffolds through Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinyl Cyclopropanes and Isatins
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- Enantioselective [3 + 2] annulation via C–H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes
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- Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies
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- Organocatalyzed aza-Michael–Michael cascade reactions to construct spirooxindole tetrahydroquinolines with all-carbon chiral centers
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- Heterocyclic Spiranes and Dispiranes via Enantioselective Phosphine-Catalyzed [3+2] Annulations
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- An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones
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- Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles
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- Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine
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- Construction of adjacent spiro-quaternary and tertiary stereocenters through phosphine-catalyzed asymmetric [3+2] annulation of allenoates with alkylidene azlactones
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- An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers
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- Enantioselective Construction of Spirooxindole Derivatives through [3+2] Annulation Catalyzed by a Bisthiourea as a Multiple-Hydrogen-Bond Donor
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- Enantioselective Organocatalyzed Cascade Reactions to Highly Functionalized Spirotetracyclic Indolenines and Oxindoles
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- Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3′-oxindole]s
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