Construction of Spirocyclic Oxindoles through Regio- and Stereoselective [3+2] or [3+2]/[4+2] Cascade Reaction of α,β-Unsaturated Imines with 3-Isothiocyanato Oxindole

Recent Advances of α-Isothiocyanato Compounds in the Catalytic Asymmetric Reaction

(2015) Wen-Yong Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Trifluoromethylated 2-Butenedioic Acid Diesters

(2015) Dan Du et al.   ChemCatChem

Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

(2015) M. J. Rawling et al.   CHEMICAL COMMUNICATIONS

Manganese catalyzed C–H functionalization of indoles with alkynes to synthesize bis/trisubstituted indolylalkenes and carbazoles: the acid is the key to control selectivity

(2015) Lijun Shi et al.   CHEMICAL COMMUNICATIONS

Gold(I)-Catalyzed Selective Heterocyclization of Propargylic Thioureas: Mechanistic Study of Competitive Gold-Activation Mode

(2015) Yu Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Enantioselective Direct Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactam to β-Acyl Acrylates and 1,2-Diacylethylenes

(2015) Yi-Ru Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective Synthesis of Dispirobarbiturates through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles

(2015) Hong-Wu Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

From meso-Lactide to Isotactic Polylactide: Epimerization by B/N Lewis Pairs and Kinetic Resolution by Organic Catalysts

(2015) Jian-Bo Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic regioselective asymmetric Michael addition of azlactones to o-hydroxy chalcone derivatives

(2015) Shao-Yun Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3-Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst

(2015) Linqing Wang et al.   ORGANIC LETTERS

Zn-Catalyzed Diastereo- and Enantioselective Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

Catalytic Aldol–Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates

(2015) Satavisha Kayal et al.   ORGANIC LETTERS

Enantioselective Synthesis of Functionalized Polycarbocycles via a Three-Component Organocascade Quadruple Reaction

(2015) Yun-Pu Chang et al.   ORGANIC LETTERS

Catalytic Enantioselective Ring-Opening and Ring-Closing Reactions of 3-Isothiocyanato Oxindoles and N-(2-Picolinoyl)aziridines

(2015) Linqing Wang et al.   ORGANIC LETTERS

Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles

(2015) Mei Bai et al.   TETRAHEDRON

Unprecedented Hydrophobic Amplification in Noncovalent Organocatalysis “on Water”: Hydrophobic Chiral Squaramide Catalyzed Michael Addition of Malonates to Nitroalkenes

(2015) Han Yong Bae et al.   ACS Catalysis

Cobalt(II)-Catalyzed Oxidative C–H Alkenylations: Regio- and Site-Selective Access to Isoindolin-1-one

(2015) Wenbo Ma et al.   ACS Catalysis

Organocatalytic Enantioselective Sulfur-Michael Addition of Thioacetic Acid to Arylmethylidenemalonates

(2014) Renchao Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Carboannulation with Allylsilanes

(2014) Nicolas R. Ball-Jones et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of P450pyr Hydroxylase for the Highly Regio- and Enantioselective Subterminal Hydroxylation of Alkanes

(2014) Yi Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amide Synthesis by Nucleophilic Attack of Vinyl Azides

(2014) Feng-Lian Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles

(2014) Hao Cai et al.   CHEMICAL COMMUNICATIONS

Enantioselective Cascade Michael Addition/Cyclization Reactions of 3-Nitro-2H-Chromenes with 3-Isothiocyanato Oxindoles: Efficient Synthesis of Functionalized Polycyclic Spirooxindoles

(2014) Fen Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Organocatalytic Activation of Unmodified Morita-Baylis-Hillman Alcohols for the Synthesis of Bicyclic α-Alkylidene-Ketones

(2014) Julian Stiller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Amide Allylation of Isatins and Its Application in the Synthesis of 2-Oxindole Derivatives Spiro-Fused to the α-Methylene-γ-Butyrolactone Functionality

(2014) Masaki Takahashi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalyzed Asymmetric 1,4-Addition of Azlactones to α,β-Unsaturated Trichloromethyl Ketones: Synthesis of α,α-Disubstituted α-Amino Acid Derivatives

(2014) Jinlong Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Michael Addition/Cyclization Cascade Reaction of 3-Isothiocyanatooxindoles with Nitro Olefins

(2014) Satavisha Kayal et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tandem Michael Addition–Ring Transformation Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with Olefinic Azlactones: Direct Access to Structurally Diverse Spirocyclic Oxindoles

(2014) Bao-Dong Cui et al.   JOURNAL OF ORGANIC CHEMISTRY

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Facile Access to Functionalized Spiro[indoline-3,2′-pyrrole]-2,5′-diones via Post-Ugi Domino Buchwald–Hartwig/Michael Reaction

(2014) Nandini Sharma et al.   ORGANIC LETTERS

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters

(2014) Bao-Dong Cui et al.   TETRAHEDRON

Organocatalytic domino Michael/cyclization reaction: efficient synthesis of multi-functionalized tetracyclic spirooxindoles with multiple stereocenters

(2014) Zu-Kang Fu et al.   RSC Advances

Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters

(2013) Dan Du et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α-Fluorinatedgem-Diols toN-Benzyl Isatins

(2013) Ibrayim Saidalimu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amine-Promoted Asymmetric (4+2) Annulations for the Enantioselective Synthesis of Tetrahydropyridines: A Traceless and Recoverable Auxiliary Strategy

(2013) Pengfei Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of Remote Stereochemistry in the Synthesis of Spirocyclic Oxindoles: Vinylogous Organocascade Catalysis

(2013) Xu Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst

(2013) Qiao Chen et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

(2013) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Counterion effects in the catalytic stereoselective synthesis of 2,3′-pyrrolidinyl spirooxindoles

(2013) Jacob P. MacDonald et al.   CHEMICAL COMMUNICATIONS

3-Isothiocyanato Oxindoles Serving as Powerful and Versatile Precursors to Structurally Diverse Dispirocyclic Thiopyrrolidineoxindoles through a Cascade Michael/Cyclization Process with Amino-Thiocarbamate Catalysts

(2013) Wen-Yong Han et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of Spirooxindoles: Asymmetric [3+2] Cycloaddition of (3-Isothiocyanato)oxindoles with Azodicarboxylates

(2013) Yu Jiang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Spirooxindoles via Direct Catalytic Asymmetric Aldol-Type Reaction of Isothiocyanato Oxindoles

(2013) Shigeki Matsunaga et al.   HETEROCYCLES

A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ-Lactams via Rh(III)-Catalyzed C–H Activation

(2013) Todd K. Hyster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient and Stereocontrolled Construction of 3,3′-Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction

(2013) Xiong-Li Liu et al.   ORGANIC LETTERS

Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines

(2013) Gongming Zhu et al.   ORGANIC LETTERS

Highly efficient synthesis of spiro[oxazolidine-2-thione-oxindoles] with 3-isothiocyanato oxindoles and aldehydes via an organocatalytic cascade aldol-cyclization reaction

(2013) Wen-Bing Chen et al.   TETRAHEDRON

Highly efficient and diastereoselective construction of bispirooxindoles through a cascade Michael-cyclization reaction

(2013) Song Wu et al.   TETRAHEDRON

cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity

(2013) Xingkuan Chen et al.   Chemical Science

A Concise Assembly of Electron-Deficient 2,4-Dienes and 2,4-Dienals: Regio- and Stereoselectiveexo-Diels-Alder and Redox Reactions through Sequential Amine and Carbene Catalysis

(2012) Chao Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles

(2012) Shota Kato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Selective Synthesis

(2012) Jessada Mahatthananchai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereodivergent Synthesis of 3-Spirocyclopropyl-2-oxindoles through Direct Enantioselective Cyclopropanation of Oxindoles

(2012) Xiaowei Dou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael-Cyclization Reaction

(2012) Hao Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′-Pyrrolidinyl Mono- and Bi-spirooxindole Frameworks

(2012) Yi-Ming Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Synthesis of Enaminophosphines via Palladacycle-Catalyzed Addition of Ph2PH to α,β-Unsaturated Imines

(2012) Yinhua Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hydrogen-Bond-Mediated Cascade Reaction Involving Chalcones: Facile Synthesis of Enantioenriched Trisubstituted Tetrahydrothiophenes

(2012) Jun-Bing Ling et al.   ORGANIC LETTERS

Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro[imidazolidine-2-thione]bisoxindoles

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

Enantioselective Intramolecular Formal [2 + 4] Annulation of Acrylates and α,β-Unsaturated Imines Catalyzed by Amino Acid Derived Phosphines

(2012) Zhichao Jin et al.   ORGANIC LETTERS

Highly enantioselective [4 + 2] annulations catalyzed by amino acid-based phosphines: Synthesis of functionalized cyclohexenes and 3-spirocyclohexene-2-oxindoles

(2012) Fangrui Zhong et al.   Chemical Science

Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles

(2011) Jie Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dioxindole in Asymmetric Catalytic Synthesis: Routes to Enantioenriched 3-Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A

(2011) Giulia Bergonzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient stereo- and regioselective hydroxylation of alkanes catalysed by a bulky polyoxometalate

(2010) Keigo Kamata et al.   Nature Chemistry

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

An enantioselective organocatalyzed aza-MBH domino process: application to the facile synthesis of tetrahydropyridines

(2010) Shinobu Takizawa et al.   TETRAHEDRON LETTERS

Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-β-lactam core of chartellines

(2009) Shigeki Sato et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction ofN-Sulfonyl-1-aza-1,3-butadienes and Aldehydes

(2008) Bo Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel Selective Aza-Morita-Baylis-Hillman (aza-MBH) Domino Reaction and Aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst

(2008) Xiangtai Meng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes

(2008) Xu Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel and facile stereocontrolled synthetic method for polyhydro-quinolines and pyridopyridazines via a diene-transmissive Diels–Alder reaction involving inverse electron-demand hetero Diels–Alder cycloaddition of cross-conjugated azatrienes

(2008) Satoru Kobayashi et al.   TETRAHEDRON

A diene-transmissive Diels–Alder reaction involving inverse electron-demand hetero-Diels–Alder cycloaddition of cross-conjugated azatrienes

(2008) Satoru Kobayashi et al.   TETRAHEDRON LETTERS