Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide

Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies

(2014) Yalda kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel spirooxindole–pyrrolidine compounds: Synthesis, anticancer and molecular docking studies

(2014) Y. Arun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Stoichiometry-controlled cycloaddition of azomethine ylide with dipolarophiles: chemoselective and regioselective synthesis of bis- and tris-spirooxindole derivatives

(2014) Srinu Lanka et al.   TETRAHEDRON LETTERS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Enantioselective Construction of Spirooxindole Derivatives: Asymmetric [3+2] Cyclization of Isothiocyanatooxindoles with Allenic Esters or 2-Butynedioic Acid Diesters

(2013) Dan Du et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2′-pyrrole] Derivatives

(2013) Feng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines

(2013) Hongchao Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trienamines Derived from Interrupted Cyclic 2,5-Dienones: Remote δ,ε-CC Bond Activation for Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction

(2013) Xin Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals

(2013) Mattia Silvi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Recoding the Genetic Code with Selenocysteine (Angew. Chem. Int. Ed. 1/2014)

(2013) Markus J. Bröcker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole–pyrrolizine–piperidine hybrids

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ-butyrolactone catalyzed by Cu(i)/DTBM-BIPHEP

(2013) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Construction of Quaternary α-Amino Acid Containing Pyrrolidines through 1,3-Dipolar Cycloaddition of Azomethine Ylides to α-Aminoacrylates

(2013) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model

(2013) Carlos E. Puerto Galvis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biomimetic Asymmetric 1,3-Dioplar Cycloaddition: Amino Acid Precursors in Biosynthesis Serve as Latent Azomethine Ylides

(2013) Chang Guo et al.   ORGANIC LETTERS

Phosphoramidite–Cu(OTf)2 Complexes as Chiral Catalysts for 1,3-Dipolar Cycloaddition of Iminoesters and Nitroalkenes

(2013) Luis M. Castelló et al.   ORGANIC LETTERS

Highly enantioselective hydrogenation of N-unprotected indoles using (S)-C10–BridgePHOS as the chiral ligand

(2013) Chao Li et al.   TETRAHEDRON

An expedient synthesis of pyrrolidinyl spirooxindole grafted 3-nitrochromanes through 1,3-dipolar cycloaddition reaction of azomethine ylides

(2013) J. Naga Siva Rao et al.   TETRAHEDRON LETTERS

Cu-mediated 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles: a faster access to spirooxindoles of potential pharmacological interest

(2013) Shambhu Nath Singh et al.   TETRAHEDRON LETTERS

Recent advances in organocatalytic asymmetric synthesis of polysubstituted pyrrolidines

(2013) Man-Yi Han et al.   TETRAHEDRON LETTERS

A novel and diastereoselective construction of H-pyrazolo[3,2-a]isoquinoline fused spirooxindoles via [3+2] cycloaddition

(2013) Panneerselvam Yuvaraj et al.   TETRAHEDRON LETTERS

Aminocatalytic Asymmetric Diels–Alder Reactions via HOMO Activation

(2012) Jun-Long Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Catalytic Asymmetric Synthesis of α-Quaternary Proline Derivatives by 1,3-Dipolar Cycloaddition of α-Silylimines

(2012) Jorge Hernández-Toribio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic stereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones

(2012) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity

(2012) Gangaru Bhaskar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of 2,3-Disubstituted Indoline Diastereoisomers by Chemoenzymatic Processes

(2012) María López-Iglesias et al.   JOURNAL OF ORGANIC CHEMISTRY

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

A Facile Access to Enantioenriched Isoindolines via One-Pot Sequential Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition/Aromatization

(2012) Zhaolin He et al.   ORGANIC LETTERS

Catalytic Asymmetric Construction of Spirocycles Containing Pyrrolidine Motifs and Spiro Quaternary Stereogenic Centers via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 2-Alkylidene-Cycloketones

(2011) Tang-Lin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability

(2011) Huicai Huang et al.   CHEMICAL COMMUNICATIONS

Highly Efficient Hydrogen-Bonding Catalysis of the Diels–Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeletons

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective synthesis of the spirotryprostatin A scaffold

(2011) Andrey P. Antonchick et al.   TETRAHEDRON

Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

(2010) Mohamed Ashraf Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asymmetric organocatalytic formal double-arylation of azomethines for the synthesis of highly enantiomerically enriched isoindolines

(2010) Chao Wang et al.   CHEMICAL COMMUNICATIONS

Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide

(2010) Arumugam Thangamani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation

(2010) Pitchaimani Prasanna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New Chiral Ferrocenyl P,S-Ligands for Highly Diastereo-/Enantioselective Catalytic [3 + 2] Cycloaddition of Azomethine Ylides with Cyclic and Acyclic Enones

(2010) Cheng Zhang et al.   ORGANIC LETTERS

HighlyEndo-Selective and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylide with α-Enones Catalyzed by a Silver(I)/ThioClickFerrophos Complex

(2010) Ichiro Oura et al.   ORGANIC LETTERS

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines

(2009) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Construction of Nitrogen-Containing [2.2.2] Bicyclic Scaffolds UsingN-(p-Dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide

(2009) Hua Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Regioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention

(2008) Raju Ranjith Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole

(2008) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY