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Title
Cushioning the cartilage: a canonical Wnt restricting matter
Authors
Keywords
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Journal
Nature Reviews Rheumatology
Volume 13, Issue 11, Pages 670-681
Publisher
Springer Nature
Online
2017-10-12
DOI
10.1038/nrrheum.2017.171
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- (2017) Shinji Takada et al. JOURNAL OF BIOCHEMISTRY
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- (2016) Xindie Zhou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
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- (2016) Jason S. Rockel et al. JOURNAL OF CLINICAL INVESTIGATION
- Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury
- (2016) Huimin Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2016) K. A. Staines et al. Arthritis & Rheumatology
- Epigenetics and aging
- (2016) S. Pal et al. Science Advances
- The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway
- (2016) Linwei Chen et al. Scientific Reports
- Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage
- (2015) Martijn H. van den Bosch et al. AMERICAN JOURNAL OF PATHOLOGY
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- (2015) Mirja Oldefest et al. BIOCHEMICAL JOURNAL
- Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury
- (2015) Dikshya Bastakoty et al. FASEB JOURNAL
- Regulation of bone metabolism by Wnt signals
- (2015) Yasuhiro Kobayashi et al. JOURNAL OF BIOCHEMISTRY
- The microRNA-29 family in cartilage homeostasis and osteoarthritis
- (2015) Linh T. T. Le et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis
- (2015) S. Thysen et al. OSTEOARTHRITIS AND CARTILAGE
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- (2014) Nobuyuki Asai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- Osteoarthritis: A disease of the joint as an organ
- (2012) Richard F. Loeser et al. ARTHRITIS AND RHEUMATISM
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- (2012) J. C. H. Leijten et al. ARTHRITIS AND RHEUMATISM
- Stimulation of superficial zone protein accumulation by hedgehog and Wnt signaling in surface zone bovine articular chondrocytes
- (2012) Takashi Iwakura et al. ARTHRITIS AND RHEUMATISM
- Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
- (2012) Martine Roudier et al. ARTHRITIS AND RHEUMATISM
- The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation
- (2012) Yoon-Sook Lee et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice
- (2012) Juliane Pasold et al. EXPERIMENTAL CELL RESEARCH
- Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
- (2012) M. C. Castano Betancourt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis
- (2012) L. Lodewyckx et al. RHEUMATOLOGY
- Alternative Wnt Pathways and Receptors
- (2012) R. van Amerongen Cold Spring Harbor Perspectives in Biology
- TCF/LEFs and Wnt Signaling in the Nucleus
- (2012) K. M. Cadigan et al. Cold Spring Harbor Perspectives in Biology
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- (2011) Melissa M. Matzelle et al. ARTHRITIS AND RHEUMATISM
- The diverse functions of Dot1 and H3K79 methylation
- (2011) A. T. Nguyen et al. GENES & DEVELOPMENT
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- (2011) Giovanna Nalesso et al. JOURNAL OF CELL BIOLOGY
- Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells
- (2011) Rika Yasuhara et al. LABORATORY INVESTIGATION
- Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
- (2011) B.Y. Chan et al. OSTEOARTHRITIS AND CARTILAGE
- GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
- (2010) M. Daans et al. ANNALS OF THE RHEUMATIC DISEASES
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- (2010) A. M. Valdes et al. ANNALS OF THE RHEUMATIC DISEASES
- R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
- (2010) Gerhard Krönke et al. ARTHRITIS AND RHEUMATISM
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
- (2010) L. Grumolato et al. GENES & DEVELOPMENT
- The bone–cartilage unit in osteoarthritis
- (2010) Rik J. Lories et al. Nature Reviews Rheumatology
- Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand
- (2009) Evangelos Evangelou et al. ARTHRITIS AND RHEUMATISM
- Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1
- (2009) Arjen B. Blom et al. ARTHRITIS AND RHEUMATISM
- Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum
- (2009) D. P. Cavalcanti et al. JOURNAL OF MEDICAL GENETICS
- Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction
- (2008) Mei Zhu et al. ARTHRITIS AND RHEUMATISM
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
- (2008) Francesco Dell'Accio et al. ARTHRITIS AND RHEUMATISM
- Transcriptional targets of sirtuins in the coordination of mammalian physiology
- (2008) Jerome N Feige et al. CURRENT OPINION IN CELL BIOLOGY
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- (2008) Wenyan Lu et al. FEBS LETTERS
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- (2008) Mei Zhu et al. JOURNAL OF BONE AND MINERAL RESEARCH
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- Deletion of frizzled-related protein reduces voluntary running exercise performance in mice
- (2008) R.J.U. Lories et al. OSTEOARTHRITIS AND CARTILAGE
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