标题
Cushioning the cartilage: a canonical Wnt restricting matter
作者
关键词
-
出版物
Nature Reviews Rheumatology
Volume 13, Issue 11, Pages 670-681
出版商
Springer Nature
发表日期
2017-10-12
DOI
10.1038/nrrheum.2017.171
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Differences in the secretion and transport of Wnt proteins
- (2017) Shinji Takada et al. JOURNAL OF BIOCHEMISTRY
- Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage
- (2017) Jiang Wu et al. Molecular Medicine Reports
- Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes
- (2017) G. Huang et al. OSTEOARTHRITIS AND CARTILAGE
- A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study
- (2017) Y. Yazici et al. OSTEOARTHRITIS AND CARTILAGE
- Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?
- (2017) Louise N. Reynard SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
- (2017) Silvia Monteagudo et al. Nature Communications
- R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
- (2017) Floriane Lacour et al. Cell Reports
- WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis
- (2016) Giovanna Nalesso et al. ANNALS OF THE RHEUMATIC DISEASES
- R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification
- (2016) Yasuhiko Takegami et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/β-catenin pathway
- (2016) Yan Zhou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis
- (2016) Ji Wang et al. FREE RADICAL RESEARCH
- Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways
- (2016) Xindie Zhou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis
- (2016) Jason S. Rockel et al. JOURNAL OF CLINICAL INVESTIGATION
- Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury
- (2016) Huimin Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice
- (2016) Wafa Bouaziz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of R-spondins and their receptors in bone metabolism
- (2016) Gui-Xun Shi et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee
- (2016) SHU-GUANG GAO et al. Experimental and Therapeutic Medicine
- Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
- (2016) Xue Yuan et al. Nature Communications
- Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
- (2016) Fatemeh Mirzamohammadi et al. Nature Communications
- A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
- (2016) Monica Florio et al. Nature Communications
- Molecular hydrogen suppresses activated Wnt/β-catenin signaling
- (2016) Yingni Lin et al. Scientific Reports
- Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model
- (2016) K. A. Staines et al. Arthritis & Rheumatology
- Epigenetics and aging
- (2016) S. Pal et al. Science Advances
- The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway
- (2016) Linwei Chen et al. Scientific Reports
- Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage
- (2015) Martijn H. van den Bosch et al. AMERICAN JOURNAL OF PATHOLOGY
- Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
- (2015) Suzanne Eldridge et al. ANNALS OF THE RHEUMATIC DISEASES
- Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3
- (2015) Mirja Oldefest et al. BIOCHEMICAL JOURNAL
- Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury
- (2015) Dikshya Bastakoty et al. FASEB JOURNAL
- Regulation of bone metabolism by Wnt signals
- (2015) Yasuhiro Kobayashi et al. JOURNAL OF BIOCHEMISTRY
- The microRNA-29 family in cartilage homeostasis and osteoarthritis
- (2015) Linh T. T. Le et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis
- (2015) S. Thysen et al. OSTEOARTHRITIS AND CARTILAGE
- Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
- (2015) Wafa Bouaziz et al. ARTHRITIS RESEARCH & THERAPY
- DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
- (2015) Ioanna Papathanasiou et al. ARTHRITIS RESEARCH & THERAPY
- Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis
- (2015) Martijn H. van den Bosch et al. Arthritis & Rheumatology
- Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation
- (2015) Xue Yuan et al. PLoS One
- LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation
- (2014) Nobuyuki Asai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction
- (2014) Arnab Barik et al. Developmental Neurobiology
- Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation
- (2014) XIAPING WENG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- R-spondins: Novel matricellular regulators of the skeleton
- (2014) M. Noelle Knight et al. MATRIX BIOLOGY
- GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition
- (2014) L. Enochson et al. OSTEOARTHRITIS AND CARTILAGE
- Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/β-Catenin Signaling
- (2014) Akira Takamatsu et al. PLoS One
- Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes
- (2014) Carole Bougault et al. ARTHRITIS RESEARCH & THERAPY
- Low-density lipoprotein receptor–related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction
- (2014) Youngnim Shin et al. ARTHRITIS RESEARCH & THERAPY
- Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice
- (2014) Thomas Funck-Brentano et al. Arthritis & Rheumatology
- Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity
- (2013) Élie Abed et al. BONE
- A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling
- (2013) Anne-Kathrin Gorny et al. Cell Communication and Signaling
- IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways
- (2013) Changdong Wang et al. EXPERIMENTAL CELL RESEARCH
- Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders
- (2013) Carmen García-Ibarbia et al. GENE
- T Cell Factor 4 Is a Pro-catabolic and Apoptotic Factor in Human Articular Chondrocytes by Potentiating Nuclear Factor κB Signaling
- (2013) Bin Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes
- (2013) Katherine C. Hall et al. MOLECULAR AND CELLULAR BIOLOGY
- To Wnt or not to Wnt: the bone and joint health dilemma
- (2013) Rik J. Lories et al. Nature Reviews Rheumatology
- Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
- (2013) K. A. Waller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation
- (2013) Ellie BM Landman et al. ARTHRITIS RESEARCH & THERAPY
- GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors
- (2013) Jeroen CH Leijten et al. ARTHRITIS RESEARCH & THERAPY
- Osteoarthritis: A disease of the joint as an organ
- (2012) Richard F. Loeser et al. ARTHRITIS AND RHEUMATISM
- Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis
- (2012) J. C. H. Leijten et al. ARTHRITIS AND RHEUMATISM
- Stimulation of superficial zone protein accumulation by hedgehog and Wnt signaling in surface zone bovine articular chondrocytes
- (2012) Takashi Iwakura et al. ARTHRITIS AND RHEUMATISM
- Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
- (2012) Martine Roudier et al. ARTHRITIS AND RHEUMATISM
- The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation
- (2012) Yoon-Sook Lee et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice
- (2012) Juliane Pasold et al. EXPERIMENTAL CELL RESEARCH
- Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
- (2012) M. C. Castano Betancourt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis
- (2012) L. Lodewyckx et al. RHEUMATOLOGY
- Alternative Wnt Pathways and Receptors
- (2012) R. van Amerongen Cold Spring Harbor Perspectives in Biology
- TCF/LEFs and Wnt Signaling in the Nucleus
- (2012) K. M. Cadigan et al. Cold Spring Harbor Perspectives in Biology
- Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway
- (2011) Melissa M. Matzelle et al. ARTHRITIS AND RHEUMATISM
- The diverse functions of Dot1 and H3K79 methylation
- (2011) A. T. Nguyen et al. GENES & DEVELOPMENT
- WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
- (2011) Giovanna Nalesso et al. JOURNAL OF CELL BIOLOGY
- Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells
- (2011) Rika Yasuhara et al. LABORATORY INVESTIGATION
- Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
- (2011) B.Y. Chan et al. OSTEOARTHRITIS AND CARTILAGE
- GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
- (2010) M. Daans et al. ANNALS OF THE RHEUMATIC DISEASES
- The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance
- (2010) A. M. Valdes et al. ANNALS OF THE RHEUMATIC DISEASES
- R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
- (2010) Gerhard Krönke et al. ARTHRITIS AND RHEUMATISM
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
- (2010) L. Grumolato et al. GENES & DEVELOPMENT
- The bone–cartilage unit in osteoarthritis
- (2010) Rik J. Lories et al. Nature Reviews Rheumatology
- Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand
- (2009) Evangelos Evangelou et al. ARTHRITIS AND RHEUMATISM
- Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1
- (2009) Arjen B. Blom et al. ARTHRITIS AND RHEUMATISM
- Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum
- (2009) D. P. Cavalcanti et al. JOURNAL OF MEDICAL GENETICS
- Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction
- (2008) Mei Zhu et al. ARTHRITIS AND RHEUMATISM
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
- (2008) Francesco Dell'Accio et al. ARTHRITIS AND RHEUMATISM
- Transcriptional targets of sirtuins in the coordination of mammalian physiology
- (2008) Jerome N Feige et al. CURRENT OPINION IN CELL BIOLOGY
- R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
- (2008) Wenyan Lu et al. FEBS LETTERS
- Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice
- (2008) Mei Zhu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
- (2008) P. Bovolenta et al. JOURNAL OF CELL SCIENCE
- Deletion of frizzled-related protein reduces voluntary running exercise performance in mice
- (2008) R.J.U. Lories et al. OSTEOARTHRITIS AND CARTILAGE
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