Regulation of bone metabolism by Wnt signals

Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a

(2015) Yasuhiro Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption

(2015) Lei Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels

(2014) Ming-Kang Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

(2014) Masanori Okamoto et al.   Scientific Reports

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

(2013) Ernesto Canalis   Nature Reviews Endocrinology

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Wntless functions in mature osteoblasts to regulate bone mass

(2012) Z. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

(2012) N. M. Collette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function

(2011) Olivier Leupin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

(2011) William F Powell et al.   JOURNAL OF ENDOCRINOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice

(2009) Ina Kramer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling

(2009) M Enomoto et al.   ONCOGENE

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

(2008) Charles A. O'Brien et al.   PLoS One