Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

(2013) Haruka Kaneko et al.   MATRIX BIOLOGY

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors

(2013) Jeroen CH Leijten et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

(2012) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

(2012) J. C. H. Leijten et al.   ARTHRITIS AND RHEUMATISM

Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk

(2012) Martha C. Castaño-Betancourt et al.   ARTHRITIS AND RHEUMATISM

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

(2012) Thomas Funck-Brentano et al.   PLoS One

Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)

(2012) A. Guermazi et al.   BMJ-British Medical Journal

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: An in vivo microfocal computed tomography study

(2011) Sander M. Botter et al.   ARTHRITIS AND RHEUMATISM

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

(2011) Maureen Pickarski et al.   BMC MUSCULOSKELETAL DISORDERS

Crosstalk between cartilage and bone: When bone cytokines matter

(2011) Thomas Funck-Brentano et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

(2011) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Cartilage biology in osteoarthritis—lessons from developmental biology

(2011) Andrew A. Pitsillides et al.   Nature Reviews Rheumatology

Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype

(2011) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

(2010) Steeve Kwan Tat et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

(2010) Sittisak Honsawek et al.   BMC MUSCULOSKELETAL DISORDERS

VEGF and its role in the early development of the long bone epiphysis

(2010) Doris Allerstorfer et al.   JOURNAL OF ANATOMY

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Identification of a stem cell niche in the zone of Ranvier within the knee joint

(2009) Camilla Karlsson et al.   JOURNAL OF ANATOMY

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

(2008) A. Kadri et al.   ARTHRITIS AND RHEUMATISM

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/ -Catenin Signaling, Osteoblast Function, and Bone Formation

(2008) E. Hay et al.   MOLECULAR AND CELLULAR BIOLOGY

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols