Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss

(2015) X Yuan et al.   CELL DEATH AND DIFFERENTIATION

Cilia Ift protein and motor -related bone diseases and mouse models

(2015) Shuying Yang   Frontiers in Bioscience-Landmark

Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

(2015) Yu Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

(2015) Jongshin Kim et al.   Nature Communications

Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation

(2015) Xue Yuan et al.   PLoS One

Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

(2014) Xue Yuan et al.   Annals of the New York Academy of Sciences

IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways

(2013) Changdong Wang et al.   EXPERIMENTAL CELL RESEARCH

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice

(2013) Takeshi Takarada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

(2013) Nataliya Razumilava et al.   JOURNAL OF HEPATOLOGY

Inhibition of Rac and ROCK Signalling Influence Osteoblast Adhesion, Differentiation and Mineralization on Titanium Topographies

(2013) Paul D. H. Prowse et al.   PLoS One

BMP2 Genetically Engineered MSCs and EPCs Promote Vascularized Bone Regeneration in Rat Critical-Sized Calvarial Bone Defects

(2013) Xiaoning He et al.   PLoS One

Mechanically induced osteogenic lineage commitment of stem cells

(2013) Julia C Chen et al.   Stem Cell Research & Therapy

Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gαq/11 - p63RhoGEF - RhoA Axis

(2013) Peter Siegert et al.   PLoS Pathogens

Effects of aspect ratios of stem cells on lineage commitments with and without induction media

(2012) Xiang Yao et al.   BIOMATERIALS

The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis

(2012) Shuying Yang et al.   BONE

Branched F-actin as a negative regulator of cilia formation

(2012) Xiumin Yan et al.   EXPERIMENTAL CELL RESEARCH

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics

(2012) Jingli Cao et al.   NATURE CELL BIOLOGY

Mechanosensing by the Primary Cilium: Deletion of Kif3A Reduces Bone Formation Due to Loading

(2012) Sara Temiyasathit et al.   PLoS One

Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium

(2012) M. F. Bijlsma et al.   Science Signaling

A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

(2011) David A. Hoey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

(2011) Zhousheng Xiao et al.   FASEB JOURNAL

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia

(2011) Suzanne Rix et al.   HUMAN MOLECULAR GENETICS

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus

(2011) J. M. Friedland-Little et al.   HUMAN MOLECULAR GENETICS

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers

(2011) T. Vallenius et al.   JOURNAL OF CELL SCIENCE

Soluble levels of cytosolic tubulin regulate ciliary length control

(2011) Neeraj Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

Do cilia put brakes on the cell cycle?

(2011) Peter K. Jackson   NATURE CELL BIOLOGY

Complex interactions between genes controlling trafficking in primary cilia

(2011) Polloneal Jymmiel R Ocbina et al.   NATURE GENETICS

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Angiogenin Enhances Cell Migration by Regulating Stress Fiber Assembly and Focal Adhesion Dynamics

(2011) Saisai Wei et al.   PLoS One

Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins

(2011) A. H. Polizio et al.   Science Signaling

Osteocyte primary cilium and its role in bone mechanotransduction

(2010) Sara Temiyasathit et al.   Annals of the New York Academy of Sciences

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

(2010) Pilar Chinchilla et al.   CELL CYCLE

Neogenin, a Receptor for Bone Morphogenetic Proteins

(2010) Meiko Hagihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis

(2010) S Kurita et al.   ONCOGENE

DYNC2H1 Mutations Cause Asphyxiating Thoracic Dystrophy and Short Rib-Polydactyly Syndrome, Type III

(2009) Nathalie Dagoneau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho Kinase Inhibitor: A Pilot Study

(2009) Hideki Yoshikawa et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Conditional Disruption ofPkd1in Osteoblasts Results in Osteopenia Due to Direct Impairment of Bone Formation

(2009) Zhousheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation

(2009) Chikahisa Higuchi et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum

(2009) D. P. Cavalcanti et al.   JOURNAL OF MEDICAL GENETICS

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA