Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

The epidemiology of osteoarthritis in Asia

(2011) Marlene FRANSEN et al.   International Journal of Rheumatic Diseases

Cartilage biology in osteoarthritis—lessons from developmental biology

(2011) Andrew A. Pitsillides et al.   Nature Reviews Rheumatology

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture

(2010) Jon Power et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin: A gem from the genome leads to bone-building antibodies

(2010) Chris Paszty et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis

(2010) C. Karlsson et al.   OSTEOARTHRITIS AND CARTILAGE

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis

(2009) Heiner Appel et al.   ARTHRITIS AND RHEUMATISM

Sclerostin in Mineralized Matrices and van Buchem Disease

(2009) R.L. van Bezooijen et al.   JOURNAL OF DENTAL RESEARCH

Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study

(2009) J. Velasco et al.   OSTEOPOROSIS INTERNATIONAL

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin protein HMGB2 regulates articular cartilage surface maintenance via  -catenin pathway

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developments in the clinical understanding of osteoarthritis

(2009) David T Felson   ARTHRITIS RESEARCH & THERAPY

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Wnt signaling and osteoarthritis

(2008) Frank P. Luyten et al.   BONE

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of  -catenin signaling causes defects in postnatal cartilage development

(2008) M. Chen et al.   JOURNAL OF CELL SCIENCE

Matrix Mineralization as a Trigger for Osteocyte Maturation

(2008) Kazuharu Irie et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

The Contribution of Genes to Osteoarthritis

(2008) Ana M. Valdes et al.   MEDICAL CLINICS OF NORTH AMERICA

Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint

(2008) L.-H. Weng et al.   OSTEOARTHRITIS AND CARTILAGE

The role of Wnt proteins in arthritis

(2008) Georg Schett et al.   Nature clinical practice. Rheumatology

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology