Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential
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Title
Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential
Authors
Keywords
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Journal
MEDICINAL RESEARCH REVIEWS
Volume 38, Issue 1, Pages 261-324
Publisher
Wiley
Online
2017-04-19
DOI
10.1002/med.21440
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Note: Only part of the references are listed.- Statin Users Without an APOE-ε4 Allele have Increased Insulin Resistance
- (2017) Brian T. VanFossen et al. JOURNAL OF ALZHEIMERS DISEASE
- Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
- (2016) Joanne S. Allard et al. BEHAVIOURAL BRAIN RESEARCH
- Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats
- (2016) Yukihiro Oritani et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
- (2016) Henrik H. Hansen et al. BRAIN RESEARCH
- Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2
- (2016) Bhakkiyalakshmi Elango et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: Potential role of serine kinases
- (2016) Nachimuthu Maithilikarpagaselvi et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease
- (2016) Mudasir Maqbool et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antioxidative and Neuroprotective Effects of Curcumin in an Alzheimer’s Disease Rat Model Co-Treated with Intracerebroventricular Streptozotocin and Subcutaneous D-Galactose
- (2016) Han-Chang Huang et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
- (2016) José A. Luchsinger et al. JOURNAL OF ALZHEIMERS DISEASE
- Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer’s Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats
- (2016) Nirmal Verma et al. JOURNAL OF ALZHEIMERS DISEASE
- Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors
- (2016) Rita Maria Concetta Di Martino et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protective effect of resveratrol against neuronal damage following transient global cerebral ischemia in mice
- (2016) Jeong-Ho Hong et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Ginsenoside Rb1 Attenuates Acute Inflammatory Nociception by Inhibition of Neuronal ERK Phosphorylation by Regulation of the Nrf2 and NF-κB Pathways
- (2016) Minhee Jang et al. JOURNAL OF PAIN
- Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model
- (2016) Huagang Li et al. Journal of Stroke & Cerebrovascular Diseases
- Cilostazol improves high glucose-induced impaired angiogenesis in human endothelial progenitor cells and vascular endothelial cells as well as enhances vasculoangiogenesis in hyperglycemic mice mediated by the adenosine monophosphate-activated protein kinase pathway
- (2016) Shih-Ya Tseng et al. JOURNAL OF VASCULAR SURGERY
- Multiplicity of effects and health benefits of resveratrol
- (2016) Lolita Kuršvietienė et al. Medicina-Lithuania
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Differential metformin dose-dependent effects on cognition in rats: role of Akt
- (2016) Dalia K. Mostafa et al. PSYCHOPHARMACOLOGY
- Evaluating preferences for profiles of glucagon-like peptide-1 receptor agonists among injection-naive type 2 diabetes patients in Japan
- (2016) Heather Gelhorn et al. Patient Preference and Adherence
- A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
- (2016) Robert G. Moses et al. Journal of Diabetes
- Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model
- (2016) Huagang Li et al. Journal of Stroke & Cerebrovascular Diseases
- Sodium-glucose co-transporter-2 inhibitors as add-on therapy to insulin: rationale and evidences
- (2016) Awadhesh Kumar Singh et al. Expert Review of Clinical Pharmacology
- Multiplicity of effects and health benefits of resveratrol
- (2016) Lolita Kuršvietienė et al. Medicina-Lithuania
- Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice
- (2016) Wenjun Zhou et al. PLoS One
- 3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease
- (2015) Federica Prati et al. ACS Chemical Neuroscience
- Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway
- (2015) Arjun Thapa et al. ACS Chemical Neuroscience
- Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial
- (2015) Sony S Thazhath et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- In Vivo Seeding and Cross-Seeding of Localized Amyloidosis
- (2015) Marie E. Oskarsson et al. AMERICAN JOURNAL OF PATHOLOGY
- Benefits and Harms of Once-Weekly Glucagon-like Peptide-1 Receptor Agonist Treatments
- (2015) Francesco Zaccardi et al. ANNALS OF INTERNAL MEDICINE
- Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways
- (2015) Feng Hao et al. APOPTOSIS
- Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice
- (2015) Paula L. McClean et al. BEHAVIOURAL BRAIN RESEARCH
- Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidine–Inhibitor Interactions
- (2015) Ling-Hsien Tu et al. BIOCHEMISTRY
- High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents
- (2015) Dmitry Petrov et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect
- (2015) Pasquale Picone et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand
- (2015) Arun K. Ghosh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
- (2015) K. G. Goozee et al. BRITISH JOURNAL OF NUTRITION
- Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain
- (2015) Haider Raza et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrol
- (2015) Martina Gobec et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Advance on the FlavonoidC-glycosides and Health Benefits
- (2015) Jianbo Xiao et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
- (2015) Fabio Lolicato et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2015) N. Hishikawa et al. EUROPEAN JOURNAL OF NEUROLOGY
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- (2015) Csenge Antus et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2015) Xi-Ding Yang et al. FITOTERAPIA
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- (2015) Camila Carla Guimarães et al. FOOD AND CHEMICAL TOXICOLOGY
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- (2015) Giovanna Viticchi et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
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- (2015) Claudia E. Ramirez et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2015) Kusal K. Das et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
- (2015) Maria Szaruga et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Modulation of the Nitrergic Pathway via Activation of PPAR-γ Contributes to the Neuroprotective Effect of Pioglitazone Against Streptozotocin-Induced Memory Dysfunction
- (2015) Atish Prakash et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains
- (2015) Linda Adzovic et al. Journal of Neuroinflammation
- Curcumin Inhibits Neuronal Loss in the Retina and Elevates Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Rats
- (2015) Jun Li et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
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- (2015) Marta Llarena et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
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- (2015) Yu Liu et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Cilostazol and freedom from amputation after lower extremity revascularization
- (2015) J. David Neel et al. JOURNAL OF VASCULAR SURGERY
- Cognitive function in patients with diabetes mellitus: guidance for daily care
- (2015) Paula S Koekkoek et al. LANCET NEUROLOGY
- Ginsenoside Compound K suppresses the hepatic gluconeogenesis via activating adenosine-5′monophosphate kinase: A study in vitro and in vivo
- (2015) Shengnan Wei et al. LIFE SCIENCES
- C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
- (2015) Hugo Gutiérrez-Hermosillo et al. MEDICINA CLINICA
- Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
- (2015) Xianchu Liu et al. METABOLIC BRAIN DISEASE
- Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury
- (2015) WEINA LI et al. Molecular Medicine Reports
- Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner
- (2015) Águeda González-Rodríguez et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
- (2015) Clémence D Côté et al. NATURE MEDICINE
- GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
- (2015) Ethan A Winkler et al. NATURE NEUROSCIENCE
- Islet α cells and glucagon—critical regulators of energy homeostasis
- (2015) Jonathan E. Campbell et al. Nature Reviews Endocrinology
- Hippocampal insulin resistance and cognitive dysfunction
- (2015) Geert Jan Biessels et al. NATURE REVIEWS NEUROSCIENCE
- Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: Implication of cilostazol for diabetes mellitus-induced dementia
- (2015) Kyoung Ja Kwon et al. NEUROBIOLOGY OF DISEASE
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
- (2015) R. Scott Turner et al. NEUROLOGY
- Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease
- (2015) Ana Ugarte et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition
- (2015) Alexander McGirr et al. NEUROPSYCHOPHARMACOLOGY
- Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats
- (2015) H.F. Zhao et al. NEUROSCIENCE
- Combined intervention with pioglitazone and n-3 fatty acids in metformin-treated type 2 diabetic patients: improvement of lipid metabolism
- (2015) Jiri Veleba et al. Nutrition & Metabolism
- Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats
- (2015) George Naijil et al. NUTRITION RESEARCH
- Resveratrol-based benzoselenophenes with an enhanced antioxidant and chain breaking capacity
- (2015) Damiano Tanini et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Tideglusib protects neural stem cells against NMDA receptor overactivation
- (2015) Güliz Armagan et al. Pharmacological Reports
- Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose- and time-dependent manner in mice
- (2015) Yu Zhou et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice
- (2015) Priya J. Ghumatkar et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Effects of Resveratrol on Receptor for Advanced Glycation End Products (RAGE) Expression and Oxidative Stress in the Liver of Rats with Type 2 Diabetes
- (2015) Mohammad Khazaei et al. PHYTOTHERAPY RESEARCH
- Cyclic GMP–mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice
- (2015) Lindsay M. Lueptow et al. PSYCHOPHARMACOLOGY
- Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion
- (2015) Bo-Ryoung Choi et al. STROKE
- A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats
- (2015) Samuel Treviño et al. SYNAPSE
- BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid
- (2015) John A. Findlay et al. Frontiers in Cellular Neuroscience
- Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
- (2015) Rebecca Deprez-Poulain et al. Nature Communications
- Efficacy and safety of vildagliptin, sitagliptin, and linagliptin as add-on therapy in Chinese patients with T2DM inadequately controlled with dual combination of insulin and traditional oral hypoglycemic agent
- (2015) Yun-Zhao Tang et al. Diabetology & Metabolic Syndrome
- Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets
- (2015) Brandon B Boland et al. Islets
- Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner
- (2015) Sandeep K. Sharma et al. Scientific Reports
- Ginsenoside Rb1 ameliorates liver fat accumulation by upregulating perilipin expression in adipose tissue of db/db obese mice
- (2015) Xizhong Yu et al. Journal of Ginseng Research
- Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons
- (2015) Naomi Mamada et al. Molecular Brain
- Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease
- (2015) M. Cuadrado-Tejedor et al. Clinical Epigenetics
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- (2015) Auriel A. Willette et al. JAMA Neurology
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- (2015) Stephen Atkin et al. Therapeutic Advances in Chronic Disease
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- (2015) Jun Sung Moon et al. Diabetes & Metabolism Journal
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- (2015) Donna G. Crenshaw et al. PLoS One
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- (2015) Mennatallah A. Ali et al. PLoS One
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- (2015) Shun-Yao Ko et al. PLoS One
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- (2014) Mark Yarchoan et al. ACTA NEUROPATHOLOGICA
- How does brain insulin resistance develop in Alzheimer's disease?
- (2014) Fernanda G. De Felice et al. Alzheimers & Dementia
- 2014 Alzheimer's disease facts and figures
- (2014) Alzheimers & Dementia
- Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation
- (2014) Kyong Kim et al. ARCHIVES OF PHARMACAL RESEARCH
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- (2014) Sorabh Sharma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2014) Elham Farsi et al. BMC Complementary and Alternative Medicine
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- (2014) Andrea Špolcová et al. BMC NEUROSCIENCE
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- (2014) Bowen Lin et al. Cardiovascular Diabetology
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- (2014) Junxiang Yin et al. Current Alzheimer Research
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- (2014) N. Hishikawa et al. EUROPEAN JOURNAL OF NEUROLOGY
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- (2014) Shuang Jiang et al. FITOTERAPIA
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- (2014) Michael Rouse et al. JOURNAL OF ENDOCRINOLOGY
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- (2014) Ana R. Jesus et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) Dongyan Tang et al. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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- (2013) P. B. Verghese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) S. I. A. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies
- (2013) Zhichun Chen et al. PROGRESS IN NEUROBIOLOGY
- Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence
- (2013) K. R. Patel et al. Science Translational Medicine
- Chemistry and Biological Activities of Flavonoids: An Overview
- (2013) Shashank Kumar et al. TheScientificWorldJOURNAL
- Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms
- (2013) Alin Stirban et al. Molecular Metabolism
- Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease
- (2012) Ana García-Osta et al. ACS Chemical Neuroscience
- Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice
- (2012) Miki Minakawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Insulin resistance in the brain: An old-age or new-age problem?
- (2012) Ritchie Williamson et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
- (2012) Seung-Chul Lee et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Expression analyses of the genes harbored by the type 2 diabetes and pediatric BMI associated locus on 10q23
- (2012) Jianhua Zhao et al. BMC Medical Genetics
- Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model
- (2012) Veronica Lifshitz et al. BRAIN BEHAVIOR AND IMMUNITY
- Cilostazol Strengthens Barrier Integrity in Brain Endothelial Cells
- (2012) Shoji Horai et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy
- (2012) Elisa Giannetta et al. CIRCULATION
- Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes
- (2012) Sanda Despa et al. CIRCULATION RESEARCH
- Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
- (2012) Cristina Carvalho et al. DIABETES
- Curcumin Extract for Prevention of Type 2 Diabetes
- (2012) S. Chuengsamarn et al. DIABETES CARE
- Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin
- (2012) Axel Bidon-Chanal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola
- (2012) Luisa Helena Cazarolli et al. FITOTERAPIA
- Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: A pilot study
- (2012) Hirofumi Sakurai et al. Geriatrics & Gerontology International
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
- (2012) Roger H. Unger et al. JOURNAL OF CLINICAL INVESTIGATION
- Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition
- (2012) C.Y. Choo et al. JOURNAL OF ETHNOPHARMACOLOGY
- Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders
- (2012) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Vascular predictors of cognitive decline in patients with mild cognitive impairment
- (2012) Giovanna Viticchi et al. NEUROBIOLOGY OF AGING
- Risk of Alzheimers Disease in Relation to Diabetes: A Population-Based Cohort Study
- (2012) Kai-Chen Wang et al. NEUROEPIDEMIOLOGY
- Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats
- (2012) Lina Qin et al. NEUROSCIENCE LETTERS
- Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
- (2012) Jayesh Kumar Bhatt et al. NUTRITION RESEARCH
- Insulin in the brain: There and back again
- (2012) William A. Banks et al. PHARMACOLOGY & THERAPEUTICS
- Inhibitory Effects of Ginsenoside Rb1 on Neuroinflammation Following Systemic Lipopolysaccharide Treatment in Mice
- (2012) Joon-Suk Lee et al. PHYTOTHERAPY RESEARCH
- Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease
- (2012) Latha Devi et al. PLoS One
- On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin
- (2012) Vincent Mascitti et al. MedChemComm
- Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
- (2012) John M Ringman et al. Alzheimers Research & Therapy
- The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
- (2012) Eric R Kandel Molecular Brain
- “Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations
- (2011) Sukanta Dolai et al. ACS Chemical Neuroscience
- cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle
- (2011) A. J. Genders et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Bioavailability of resveratrol
- (2011) Thomas Walle Annals of the New York Academy of Sciences
- Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation
- (2011) Sun Haeng Park et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anti-platelet therapy: phosphodiesterase inhibitors
- (2011) Paolo Gresele et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
- (2011) Pál Brasnyó et al. BRITISH JOURNAL OF NUTRITION
- Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β
- (2011) Ali Reza A. Ladiwala et al. CHEMBIOCHEM
- Flavonoids as Acetylcholinesterase Inhibitors
- (2011) I. Uriarte-Pueyo et al. CURRENT MEDICINAL CHEMISTRY
- Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding
- (2011) Sanshiro Tateya et al. DIABETES
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
- (2011) R. Grempler et al. DIABETES OBESITY & METABOLISM
- Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease
- (2011) Suzanne M. de la Monte DRUGS
- Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib
- (2011) Juan Manuel Domínguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
- (2011) Subbiah Pugazhenthi et al. Molecular Neurodegeneration
- Enhancing the bioavailability of resveratrol by combining it with piperine
- (2011) Jeremy J. Johnson et al. MOLECULAR NUTRITION & FOOD RESEARCH
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- (2011) Jaewon Chang et al. NEUROBIOLOGY OF AGING
- Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease
- (2011) B. DaRocha-Souto et al. NEUROBIOLOGY OF DISEASE
- The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
- (2011) P.H. Hutson et al. NEUROPHARMACOLOGY
- Biology of Human Sodium Glucose Transporters
- (2011) Ernest M. Wright et al. PHYSIOLOGICAL REVIEWS
- Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
- (2011) Per Westermark et al. PHYSIOLOGICAL REVIEWS
- Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance
- (2011) Samer O. Abdul-Hay et al. PLoS One
- Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity
- (2011) B Omar et al. Nutrition & Diabetes
- Safety and pharmacokinetics of PF-04447943, a PDEA inhibitor, in single and multiple dose Phase 1 studies in healthy volunteers
- (2010) Rebecca M. Evans et al. Alzheimers & Dementia
- α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion
- (2010) Xuehui Geng et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity
- (2010) Marie Daval et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Reduced NO-cGMP Signaling Contributes to Vascular Inflammation and Insulin Resistance Induced by High-Fat Feeding
- (2010) Norma O. Rizzo et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
- (2010) Eisuke Kato et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?
- (2010) Kawser Akter et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Cilostazol prevents amyloid β peptide25-35-induced memory impairment and oxidative stress in mice
- (2010) Masayuki Hiramatsu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells
- (2010) Ronn S. Friedlander et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats
- (2010) Y. Xiong et al. DIABETES
- Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
- (2010) W. Xu et al. DIABETES
- Is insulin resistance a disorder of the brain?
- (2010) Undurti et al. Frontiers in Bioscience-Landmark
- Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers
- (2010) Ali Reza A. Ladiwala et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
- (2010) Christopher D. Morrison et al. JOURNAL OF NEUROCHEMISTRY
- Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging
- (2010) Debjani Tripathy et al. Journal of Neuroinflammation
- Alzheimer's disease: clinical trials and drug development
- (2010) Francesca Mangialasche et al. LANCET NEUROLOGY
- Chronic Inflammation in Obesity and the Metabolic Syndrome
- (2010) Rosário Monteiro et al. MEDIATORS OF INFLAMMATION
- Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease
- (2010) Katarzyna Urszula Domek-Łopacińska et al. MOLECULAR NEUROBIOLOGY
- Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease
- (2010) Margarita C Dinamarca et al. Molecular Neurodegeneration
- Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
- (2010) Mahiuddin Ahmed et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging
- (2010) Vincenzo Solfrizzi et al. NEUROBIOLOGY OF AGING
- AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation
- (2010) Michela Guglielmotto et al. NEUROBIOLOGY OF AGING
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phloridzin: Biosynthesis, distribution and physiological relevance in plants
- (2010) Christian Gosch et al. PHYTOCHEMISTRY
- Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats
- (2010) Amélia P. Rauter et al. PHYTOTHERAPY RESEARCH
- Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
- (2010) Malcolm A. Leissring et al. PLoS One
- Amyloid fibrils
- (2010) Roma N. Rambaran et al. Prion
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- Memantine
- (2009) Massimo Tabaton et al. AMERICAN JOURNAL OF PATHOLOGY
- The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
- (2009) Michael P. DeNinno et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release
- (2009) WK Ong et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2009) Rajesh Mishra et al. CHEMBIOCHEM
- Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
- (2009) R. L. Hull et al. DIABETOLOGIA
- Stimulatory effect of apigenin-6-C-β-l-fucopyranoside on insulin secretion and glycogen synthesis
- (2009) Luisa Helena Cazarolli et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera
- (2009) Amélia P. Rauter et al. JOURNAL OF ETHNOPHARMACOLOGY
- Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
- (2009) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes
- (2009) Natalia Rudovich et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains
- (2009) Hedvig Welander et al. JOURNAL OF NEUROCHEMISTRY
- Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
- (2009) V. Solfrizzi et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Cilostazol Ameliorates Metabolic Abnormalities with Suppression of Proinflammatory Markers in a db/db Mouse Model of Type 2 Diabetes via Activation of Peroxisome Proliferator-Activated Receptor Transcription
- (2009) S. Y. Park et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- PIOGLITAZONE IMPROVED COGNITION IN A PILOT STUDY ON PATIENTS WITH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT WITH DIABETES MELLITUS
- (2009) Haruo Hanyu et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Oxidative stress and metabolic syndrome
- (2009) Christian K. Roberts et al. LIFE SCIENCES
- Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease
- (2009) Tomohiko Sato et al. NEUROBIOLOGY OF AGING
- A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
- (2009) L. Serenó et al. NEUROBIOLOGY OF DISEASE
- Protective effect of ginsenoside Rb1 onβ-amyloid protein(1-42)-induced neurotoxicity in cortical neurons
- (2009) Yi-Hua Qian et al. NEUROLOGICAL RESEARCH
- Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management
- (2009) K. Tziomalos et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
- (2008) Alex E. Roher et al. Alzheimers & Dementia
- Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes
- (2008) K. Suzuki et al. AMERICAN JOURNAL OF HYPERTENSION
- Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation
- (2008) Crystal M. Cordes et al. BIOCHEMICAL PHARMACOLOGY
- The blood-brain barrier in brain homeostasis and neurological diseases
- (2008) Nicolas Weiss et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of β-amyloid peptide25–35-induced tau hyperphosphorylation in cortical neurons
- (2008) Xiaochun Chen et al. BRAIN RESEARCH
- Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
- (2008) Xiumei Zuo et al. BRAIN RESEARCH
- Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: The Three-City Study
- (2008) C. Raffaitin et al. DIABETES CARE
- Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4
- (2008) S. Casas et al. DIABETOLOGIA
- Brain Regulation of Appetite and Satiety
- (2008) Rexford S. Ahima et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats
- (2008) Takayuki Matsumoto et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Non-hydrolytic functions of acetylcholinesterase
- (2008) Susan A. Greenfield et al. FEBS Journal
- Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes
- (2008) Anna Kotronen et al. GASTROENTEROLOGY
- Metabolic syndrome risk for cardiovascular disease and diabetes in the ARIC study
- (2008) C M Ballantyne et al. INTERNATIONAL JOURNAL OF OBESITY
- Inhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequentin vitro/in vivoevaluation
- (2008) Yasser Bustanji et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α
- (2008) Michela Guglielmotto et al. JOURNAL OF NEUROCHEMISTRY
- Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin
- (2008) C.G. Jolivalt et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
- (2008) Robert L Wilensky et al. NATURE MEDICINE
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
- (2008) Ganesh M Shankar et al. NATURE MEDICINE
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
- Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity
- (2008) Andrea Tarozzi et al. NEUROREPORT
- Assessment of oxidative stress and endothelial dysfunction in Asian Indians with type 2 diabetes mellitus with and without macroangiopathy
- (2008) N. Singhania et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3
- (2007) Seong-Ho Koh et al. BRAIN RESEARCH
- Amyloid beta oligomers induce impairment of neuronal insulin receptors
- (2007) Wei-Qin Zhao et al. FASEB JOURNAL
- Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts
- (2007) Xiaofang Peng et al. FOOD CHEMISTRY
- Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
- (2003) Craig S. Atwood et al. JOURNAL OF NEUROCHEMISTRY
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