Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease

(2014) Elias Schwam et al.   Current Alzheimer Research

PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition

(2014) Katja S. Kroker et al.   NEUROBIOLOGY OF AGING

Modulating nitric oxide signaling in the CNS for Alzheimer’s disease therapy

(2013) Qin Zhihui   Future Medicinal Chemistry

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

Determination of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by solid phase extraction on silica and liquid chromatography–triple quadrupole mass spectrometry

(2012) Thomas Van Damme et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

(2012) Michelle M. Claffey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

(2012) Carolina García-Barroso et al.   NEUROPHARMACOLOGY

CSF Concentrations of cAMP and cGMP Are Lower in Patients with Creutzfeldt-Jakob Disease but Not Parkinson's Disease and Amyotrophic Lateral Sclerosis

(2012) Patrick Oeckl et al.   PLoS One

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

(2011) M Cuadrado-Tejedor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simultaneous LC–MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue

(2011) Patrick Oeckl et al.   JOURNAL OF NEUROSCIENCE METHODS

Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease

(2010) Katarzyna Urszula Domek-Łopacińska et al.   MOLECULAR NEUROBIOLOGY

Selective D1 agonism but not D2 antagonism is reflected in cAMP and cGMP levels in rat CSF

(2009) An Torremans et al.   BRAIN RESEARCH BULLETIN

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Lowered cAMP and cGMP signalling in the brain during levodopa-induced dyskinesias in hemiparkinsonian rats: new aspects in the pathogenetic mechanisms

(2008) M. Giorgi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases

(2008) Hayrettin Tumani et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats

(2008) Antonella Marte et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY