Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

Peripheral Amyloid-β Levels Regulate Amyloid-β Clearance from the Central Nervous System

(2017) Marcos A. Marques et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Truncated Tau is Using a Different Mechanism from Amyloid-β to Damage the Blood-Brain Barrier

(2017) Andrej Kovac et al.   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity

(2017) Mária A. Deli et al.   JOURNAL OF ALZHEIMERS DISEASE

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelin-1 is Elevated in Alzheimer's Disease Brain Microvessels and is Neuroprotective

(2017) Jinhua Luo et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade

(2014) Kie Honjo et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

(2013) Manja Lehmann et al.   BRAIN

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Diabetes, Glucose Control, and 9-Year Cognitive Decline Among Older Adults Without Dementia

(2012) Kristine Yaffe et al.   ARCHIVES OF NEUROLOGY

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

Early Brain Injury Alters the Blood–Brain Barrier Phenotype in Parallel with β-Amyloid and Cognitive Changes in Adulthood

(2012) Viorela Pop et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier

(2012) Thorsten Pflanzner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

(2012) Akihiko Hoshi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Does vascular pathology contribute to Alzheimer changes?

(2012) Raj N. Kalaria et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Serum biomarkers of spontaneous intracerebral hemorrhage induced secondary brain injury

(2012) Andrew S. Brunswick et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Aquaporin-4 mediates astrocyte response to β-amyloid

(2012) Wei Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurovascular Unit: a Focus on Pericytes

(2012) Inês Sá-Pereira et al.   MOLECULAR NEUROBIOLOGY

Innate Immunity and the Etiology of Late-Onset Alzheimer’s Disease

(2012) Piet Eikelenboom et al.   Neurodegenerative Diseases

A Multifaceted Role for apoE in the Clearance of Beta-Amyloid across the Blood-Brain Barrier

(2012) Corbin Bachmeier et al.   Neurodegenerative Diseases

Staging and natural history of cerebrovascular pathology in dementia

(2012) V. Deramecourt et al.   NEUROLOGY

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Drug delivery to the brain in Alzheimer's disease: Consideration of the blood–brain barrier

(2011) William A. Banks   ADVANCED DRUG DELIVERY REVIEWS

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

Vascular signaling abnormalities in Alzheimer disease

(2011) P. GRAMMAS et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes

(2011) Sandra D. Mulder et al.   EXPERIMENTAL NEUROLOGY

Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes

(2011) Rea Pihlaja et al.   GLIA

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurovascular function in Alzheimer's disease patients and experimental models

(2011) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

(2011) Masachika Fujiyoshi et al.   JOURNAL OF NEUROCHEMISTRY

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

(2011) Fuyuko Takata et al.   Journal of Neuroinflammation

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

(2011) Andrej Kovac et al.   Journal of Neuroinflammation

Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice

(2011) Steven M. Rauch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A Neurovascular Perspective for Long-Term Changes After Brain Trauma

(2011) V. Pop et al.   Translational Stroke Research

Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors

(2010) K. Blennow et al.   ACTA NEUROLOGICA SCANDINAVICA

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

(2010) Xiangling Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

P-glycoprotein and breast cancer resistance protein expression and function at the blood–brain barrier and blood–cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats

(2010) Valeska Reichel et al.   BRAIN RESEARCH

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aquaporin Expression in the Brains of Patients With or Without Cerebral Amyloid Angiopathy

(2010) Parham Moftakhar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

MAPK induces AQP1 expression in astrocytes following injury

(2009) Eric Mccoy et al.   GLIA

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune blood biomarkers of Alzheimer disease patients

(2009) Hripsime Avagyan et al.   JOURNAL OF NEUROIMMUNOLOGY

β-Amyloid Accumulation in Neurovascular Units Following Brain Embolism

(2009) Feng Han et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Is it appropriate to use albumin CSF/plasma ratio to assess blood brain barrier permeability?

(2009) Ruo-Li Chen   NEUROBIOLOGY OF AGING

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice

(2009) Hao Hong et al.   NEUROPHARMACOLOGY

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study

(2009) John M. Starr et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice

(2009) Li Ping Liu et al.   SYNAPSE

The Precapillary Segment of the Blood-Brain Barrier and Its Relation to Perivascular Drainage in Alzheimer's Disease and Small Vessel Disease.

(2009) Dietmar R. Thal   TheScientificWorldJOURNAL

Pathophysiology of vascular dementia

(2009) Francesco Iemolo et al.   Immunity & Ageing

Close association of water channel AQP1 with amyloid-β deposition in Alzheimer disease brains

(2008) Tamako Misawa et al.   ACTA NEUROPATHOLOGICA

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

Astroglia in dementia and Alzheimer's disease

(2008) J J Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis

(2008) Brian Jeynes et al.   Current Alzheimer Research

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

(2008) Akihiko Urayama et al.   ENDOCRINOLOGY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase

(2008) Laia Tolosa et al.   JOURNAL OF NEUROCHEMISTRY

Soluble aggregates of the amyloid-β protein selectively stimulate permeability in human brain microvascular endothelial monolayers

(2008) Francisco J. Gonzalez-Velasquez et al.   JOURNAL OF NEUROCHEMISTRY

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

(2008) M.-C. Lacroix et al.   JOURNAL OF NEUROENDOCRINOLOGY

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

Aβ accumulation in choroid plexus is associated with mitochondrial-induced apoptosis

(2008) Teo Vargas et al.   NEUROBIOLOGY OF AGING

RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role

(2008) Debjani Tripathy et al.   NEUROBIOLOGY OF AGING

Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

(2008) Oskar Hansson et al.   NEUROBIOLOGY OF AGING

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING