Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus

(2010) Xiaoya Zheng et al.   ACTA DIABETOLOGICA

Design and study of peptide-based inhibitors of amylin cytotoxicity

(2010) Karen Muthusamy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

(2010) Daniel Sellin et al.   BIOPHYSICAL CHEMISTRY

Untangling the unfolded protein response

(2010) Emma L. Davenport et al.   CELL CYCLE

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Neprilysin Impedes Islet Amyloid Formation by Inhibition of Fibril Formation Rather Than Peptide Degradation

(2010) Sakeneh Zraika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Fatty acids induce amylin expression and secretion by pancreatic β-cells

(2009) Dongfei Qi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Aß1-42 or IAPP

(2009) Ying Zhang et al.   APOPTOSIS

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro

(2009) Lucie Khemtémourian et al.   BIOCHEMISTRY

The Ability of Rodent Islet Amyloid Polypeptide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications for the Mechanism of Amyloid Formation and the Design of Inhibitors

(2009) Ping Cao et al.   BIOCHEMISTRY

Amyloid inhibitors enhance survival of cultured human islets

(2009) Kathryn J. Potter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Disproportionate Hyperproinsulinemia, β-Cell Restricted Prohormone Convertase 2 Deficiency, and Cell Cycle Inhibitors Expression by Human Islets Transplanted into Athymic Nude Mice: Insights into Nonimmune-Mediated Mechanisms of Delayed Islet Graft Failure

(2009) Alberto M. Davalli et al.   CELL TRANSPLANTATION

A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes

(2009) James A. Hebda et al.   CHEMISTRY & BIOLOGY

Endoplasmic reticulum stress in β-cells and development of diabetes

(2009) Sonya G Fonseca et al.   CURRENT OPINION IN PHARMACOLOGY

Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

(2009) J. F. Aitken et al.   DIABETES

Counterpoint: Clinical Islet Transplantation: Not Ready for Prime Time

(2009) M. H. Khan et al.   DIABETES CARE

Point: Steady Progress and Current Challenges in Clinical Islet Transplantation

(2009) D. Mineo et al.   DIABETES CARE

Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation

(2009) M.-C. Vantyghem et al.   DIABETES CARE

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

(2009) R. L. Hull et al.   DIABETOLOGIA

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

(2009) Natasha C Chang et al.   EMBO JOURNAL

Porcine Marginal Mass Islet Autografts Resist Metabolic Failure Over Time and Are Enhanced by Early Treatment with Liraglutide

(2009) Juliet A. Emamaullee et al.   ENDOCRINOLOGY

Competing discrete interfacial effects are critical for amyloidogenesis

(2009) Létitia Jean et al.   FASEB JOURNAL

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

(2009) Sarah Waters et al.   FEBS LETTERS

Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

(2009) Masaki Wakabayashi et al.   FEBS LETTERS

Localized insulin-derived amyloidosis in patients with diabetes mellitus: a case report

(2009) Saniye Yumlu et al.   HUMAN PATHOLOGY

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Regulates Assembly of Human Islet Amyloid Polypeptide on Model Membranes

(2009) Won-Jin Cho et al.   JOURNAL OF MOLECULAR BIOLOGY

Central amylin expression and its induction in rat dams

(2009) Arpád Dobolyi   JOURNAL OF NEUROCHEMISTRY

Conformation Preorganization: Effects of S20G Mutation on the Structure of Human Islet Amyloid Polypeptide Segment

(2009) Weixin Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

(2009) Ravi Prakash Reddy Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy

(2009) Ronald Soong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide

(2009) Pieter E. S. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of IAPP and IAPP(20−29)Fibrillation by Polymeric Nanoparticles

(2009) C. Cabaleiro-Lago et al.   LANGMUIR

Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme

(2009) Anthony DelleDonne et al.   Molecular Neurodegeneration

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Pancreatic islet amyloidosis,  -cell apoptosis, and  -cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

(2009) R. Guardado-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss

(2009) R Neal Smith et al.   TRANSPLANTATION

The Interaction between Impaired Acute Insulin Response and Insulin Resistance Predict Type 2 Diabetes and Impairment of Fasting Glucose

(2009) Björn Zethelius et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control

(2008) Simona I. Chisalita et al.   ACTA DIABETOLOGICA

The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism

(2008) D. Naot et al.   BONE

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunzytochemische Morphometrie beim Typ-I- und Typ-II-Diabetes mellitus*

(2008) G. Klöppel et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

(2008) L. Marzban et al.   DIABETES

Physiological and Molecular Determinants of Insulin Action in the Baboon

(2008) A. O. Chavez et al.   DIABETES

Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide

(2008) H. J. Woerle et al.   DIABETES CARE

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

(2008) J. Udayasankar et al.   DIABETOLOGIA

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

(2008) Maria Morfis et al.   ENDOCRINOLOGY

Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role inβ-Cell Death in Type 2 Diabetes Mellitus

(2008) Lucie Khemtémourian et al.   Experimental Diabetes Research

The Role of the 14–20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation

(2008) Sharon Gilead et al.   Experimental Diabetes Research

C-Peptide and Its C-Terminal Fragments Improve Erythrocyte Deformability in Type 1 Diabetes Patients

(2008) Thomas Hach et al.   Experimental Diabetes Research

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

(2008) Véronique Serre-Beinier et al.   HUMAN MOLECULAR GENETICS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteins Associated with Immunopurified Granules from a Model Pancreatic Islet β-Cell System: Proteomic Snapshot of an Endocrine Secretory Granule

(2008) Anthony J. R. Hickey et al.   JOURNAL OF PROTEOME RESEARCH

Structure and Dynamics of a Partially Folded Protein Are Decoupled from Its Mechanism of Aggregation

(2008) Giulia Calloni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oscillatory control of insulin secretion

(2008) A TENGHOLM et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Amyloid and Transplanted Islets

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets

(2008) Gunilla T. Westermark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular characterization of calcitonin gene-related peptide (CGRP) related peptides (CGRP, amylin, adrenomedullin and adrenomedullin-2/intermedin) in goldfish (Carassius auratus): Cloning and distribution

(2008) R.M. Martínez-Álvarez et al.   PEPTIDES

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

(2008) Jed J.W. Wiltzius et al.   PROTEIN SCIENCE

Gastric emptying in response to IAPP and CCK in rats with subdiaphragmatic afferent vagotomy

(2008) Johan Wickbom et al.   REGULATORY PEPTIDES

A Picky Eater: Exploring the Mechanisms of Selective Autophagy in Human Pathologies

(2008) Aniek van der Vaart et al.   TRAFFIC

Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

(2004) Bon W. Koo et al.   PROTEIN SCIENCE