Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

(2014) D J Porteous et al.   MOLECULAR PSYCHIATRY

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

(2013) Taiji Goto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PDE4 as a target for cognition enhancement

(2013) Wito Richter et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Enhanced inhibitory neurotransmission in the cerebellar cortex ofAtp1a3-deficient heterozygous mice

(2013) Keiko Ikeda et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na+,K+-ATPase α3 Missense Mutant Mice

(2013) Greer S. Kirshenbaum et al.   PLoS One

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

(2012) Constantinos D. Paspalas et al.   CEREBRAL CORTEX

Attenuating the persistence of fear memory storage using a single dose of antidepressant

(2012) L Slipczuk et al.   MOLECULAR PSYCHIATRY

General learning ability regulates exploration through its influence on rate of habituation

(2011) Kenneth R. Light et al.   BEHAVIOURAL BRAIN RESEARCH

Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese

(2011) Fanglin Guan et al.   HUMAN GENETICS

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats

(2011) Ling-Xia Li et al.   METABOLIC BRAIN DISEASE

Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice

(2011) Kris Rutten et al.   NEUROPHARMACOLOGY

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses

(2009) Liisa Tomppo et al.   BIOLOGICAL PSYCHIATRY

Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy

(2009) Cristina Marchetti et al.   BIOLOGICAL PSYCHIATRY

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

(2009) Bechara J. Saab et al.   NEURON

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of amygdalar PKA by  -arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia

(2009) Anjali Rastogi et al.   SCHIZOPHRENIA RESEARCH

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

(2008) Shusuke Numata et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Up-regulation of exploratory tendencies does not enhance general learning abilities in juvenile or young-adult outbred mice

(2008) Kenneth R. Light et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats

(2008) M.N. de Lima et al.   NEUROPHARMACOLOGY

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH