Bioactivity of Olive Oil Phenols in Neuroprotection

Protective effect of hydroxytyrosol in arsenic-induced mitochondrial dysfunction in rat brain

(2017) Manisha Soni et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2017) Wenyan Sun et al.   NEUROPHARMACOLOGY

Oleocanthal ameliorates amyloid-β oligomers’ toxicity on astrocytes and neuronal cells: In vitro studies

(2017) Yazan S. Batarseh et al.   NEUROSCIENCE

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer’s disease: as it was in the beginning

(2017) Stanislav Kozlov et al.   REVIEWS IN THE NEUROSCIENCES

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Protective effects of fisetin and other berry flavonoids in Parkinson's disease

(2017) Pamela Maher   Food & Function

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

Traumatic spinal cord injury

(2017) Christopher S. Ahuja et al.   Nature Reviews Disease Primers

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

(2017) Marcela Cruz-Haces et al.   Translational Neurodegeneration

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Oleuropein, a natural extract from plants, offers neuroprotection in focal cerebral ischemia/reperfusion injury in mice

(2016) Hailong Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

(2016) Fiorella Casamenti et al.   Expert Review of Neurotherapeutics

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats

(2016) Soheila Pourkhodadad et al.   Journal of Physiological Sciences

Oleuropein ameliorates arsenic induced oxidative stress in mice

(2016) Metin Ogun et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice

(2016) Yunhua Peng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells

(2016) David S. Goldstein et al.   NEUROCHEMICAL RESEARCH

Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity

(2016) Guohua Yu et al.   NEUROCHEMISTRY INTERNATIONAL

Review: Parkinson's disease: from synaptic loss to connectome dysfunction

(2016) Arianna Bellucci et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

(2016) Massimiliano De Paola et al.   PHARMACOLOGICAL RESEARCH

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Immunology of Multiple Sclerosis

(2016) Mireia Sospedra et al.   SEMINARS IN NEUROLOGY

Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

(2016) Fiorella Casamenti et al.   Expert Review of Neurotherapeutics

Mediterranean Diet and Risk of Dementia

(2015) Apostolos Safouris et al.   Current Alzheimer Research

Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants

(2015) Amir Sarrafchi et al.   CURRENT PHARMACEUTICAL DESIGN

Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins

(2015) Ken Declerck et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: A review

(2015) Chandra Prakash et al.   JOURNAL OF APPLIED TOXICOLOGY

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

(2015) Hisham Qosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

(2015) Jose Rodríguez-Morató et al.   MOLECULES

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

(2015) Ilaria Luccarini et al.   NEUROBIOLOGY OF AGING

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

The Ubiquitin-Proteasome System in Neurodegeneration

(2014) Chris McKinnon et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

Extra virgin olive oil intake delays the development of amyotrophic lateral sclerosis associated with reduced reticulum stress and autophagy in muscle of SOD1G93A mice

(2014) Sara Oliván et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity

(2014) P. Browne et al.   NEUROLOGY

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

(2014) Elena Gallardo et al.   RSC Advances

Role of Methylglyoxal in Alzheimer’s Disease

(2014) Cristina Angeloni et al.   Biomed Research International

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Neuroprotection of Dietary Virgin Olive Oil on Brain Lipidomics During Stroke

(2013) Zahra Rabiei et al.   CURRENT NEUROVASCULAR RESEARCH

Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson’s disease

(2013) Pradeep Dewapriya et al.   FOOD CHEMISTRY

Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial

(2013) Elena H Martínez-Lapiscina et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

(2013) Vincent B. Owona Ayissi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain

(2013) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Inhibition of 6-Hydroxydopamine-Induced PC12 Cell Apoptosis by Olive (Olea europaea L.) Leaf Extract Is Performed by Its Main Component Oleuropein

(2013) Hamzeh Pasban-Aliabadi et al.   REJUVENATION RESEARCH

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Relation of the Traditional Mediterranean Diet to Cerebrovascular Disease in a Mediterranean Population

(2012) G. Misirli et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice

(2012) Daniela Impellizzeri et al.   BIOCHEMICAL PHARMACOLOGY

Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis

(2012) R Martín et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes

(2012) Nidhi Bhutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Tau Protein Fibrillization by Oleocanthal

(2012) Maria Chiara Monti et al.   JOURNAL OF NATURAL PRODUCTS

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Enfermedad de Parkinson y enfermedad de Alzheimer: factores de riesgo ambientales

(2012) J. Campdelacreu   NEUROLOGIA

Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease

(2012) P.-C. Lee et al.   NEUROLOGY

Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli

(2012) Don James et al.   NUTRITION REVIEWS

Potential benefits of adherence to the Mediterranean diet on cognitive health

(2012) Catherine Féart et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Long-Term Dietary Extra-Virgin Olive Oil Rich in Polyphenols Reverses Age-Related Dysfunctions in Motor Coordination and Contextual Memory in Mice: Role of Oxidative Stress

(2012) Vanessa Pitozzi et al.   REJUVENATION RESEARCH

Monoamine Oxidase B Inhibitors for the Treatment of Parkinsonʼs Disease

(2011) Anthony H.V. Schapira   CNS DRUGS

Tyrosol and Hydroxytyrosol Two Main Components of Olive Oil, Protect N2a Cells Against Amyloid-β-Induced Toxicity. Involvement of the NF-κB Signaling

(2011) C. St-Laurent-Thibault et al.   Current Alzheimer Research

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

(2011) Stefania Rigacci et al.   Current Alzheimer Research

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

Effects of acetaminophen on reactive oxygen species and nitric oxide redox signaling in kidney of arsenic-exposed rats

(2011) Chhaya Rani Majhi et al.   FOOD AND CHEMICAL TOXICOLOGY

Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

(2011) Sebastian Schaffer et al.   Genes and Nutrition

Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake

(2011) Aida Serra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Structure-Dependent Inhibition of Gelatinases by Dietary Antioxidants in Rat Astrocytes and Sera of Multiple Sclerosis Patients

(2011) Grazia Maria Liuzzi et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of oleuropein following spinal cord injury in rats

(2011) Ali Reza Khalatbary et al.   NEUROLOGICAL RESEARCH

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Dietary Virgin Olive Oil Reduces Blood Brain Barrier Permeability, Brain Edema, and Brain Injury in Rats Subjected to Ischemia-Reperfusion

(2011) Fatemeh Mohagheghi et al.   TheScientificWorldJOURNAL

Mechanisms of action of isothiocyanates in cancer chemoprevention: an update

(2011) Sandi L. Navarro et al.   Food & Function

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

(2011) Maria Chiara Monti et al.   Food & Function

Exploratory analysis of human urine by LC–ESI-TOF MS after high intake of olive oil: understanding the metabolism of polyphenols

(2010) Rocío García-Villalba et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease

(2010) Nikolaos Scarmeas et al.   ANNALS OF NEUROLOGY

Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

(2010) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies

(2010) Gulrana Khuwaja et al.   BRAIN RESEARCH

Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats

(2010) Vanessa Pitozzi et al.   BRITISH JOURNAL OF NUTRITION

EFNS guidelines for the diagnosis and management of Alzheimer’s disease

(2010) J. Hort et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes

(2010) David Vauzour et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nutraceutical Antioxidants as Novel Neuroprotective Agents

(2010) Natalie A. Kelsey et al.   MOLECULES

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008

(2010) J. López-Miranda et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins

(2010) Maria González-Santiago et al.   PHARMACOLOGICAL RESEARCH

Current and emerging treatments for amyotrophic lateral sclerosis

(2010) Zoccolella   Neuropsychiatric Disease and Treatment

Treatment strategies for Parkinson’s disease

(2010) Hong Yuan et al.   Neuroscience Bulletin

Mediterranean Diet and Mild Cognitive Impairment

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

(2009) Rubén Martín et al.   BIOCHEMICAL PHARMACOLOGY

Mediterranean diet and cognitive function in older adults

(2009) Catherine Féart et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Olive Oil and Cognition: Results from the Three-City Study

(2009) Claudine Berr et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells

(2009) A. Melchini et al.   FOOD AND CHEMICAL TOXICOLOGY

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease

(2009) Ana Navarro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease

(2009) Teresa G. Hastings   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line

(2009) Andrea Tarozzi et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms

(2009) Maria C Rodriguez-Oroz et al.   LANCET NEUROLOGY

Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

(2009) Jason Pitt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure

(2009) M. Servili et al.   INFLAMMOPHARMACOLOGY

Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson’s disease and protection by polyphenols

(2008) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane

(2008) Natalya Hanlon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The neuroprotective potential of flavonoids: a multiplicity of effects

(2008) David Vauzour et al.   Genes and Nutrition

Effects of Hydroxytyrosol and Hydroxytyrosol Acetate Administration to Rats on Platelet Function Compared to Acetylsalicylic Acid

(2008) José Antonio González-Correa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms

(2008) Manjeet Singh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health

(2008) Ruud Verkerk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia–reoxygenation

(2008) José Antonio González-Correa et al.   NEUROSCIENCE LETTERS

Bioavailability of olive oil phenolic compounds in humans

(2008) R. de la Torre   INFLAMMOPHARMACOLOGY

Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

(2007) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING

MMPs in the central nervous system: Where the good guys go bad

(2007) S AGRAWAL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY