Review: Parkinson's disease: from synaptic loss to connectome dysfunction

Distinct higher-order α-synuclein oligomers induce intracellular aggregation

(2015) Eva Illes-Toth et al.   BIOCHEMICAL JOURNAL

β-Amyloid and α-Synuclein Cooperate To Block SNARE-Dependent Vesicle Fusion

(2015) Bong-Kyu Choi et al.   BIOCHEMISTRY

Connectivity measures are robust biomarkers of cortical function and plasticity after stroke

(2015) Jennifer Wu et al.   BRAIN

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Lewy Bodies: A Spectator or Salient Killer?

(2015) Jeswinder Sian-Hulsmann et al.   CNS & Neurological Disorders-Drug Targets

Selective expression of Parkinson's disease-relatedLeucine-rich repeat kinase 2G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

(2015) Guoxiang Liu et al.   HUMAN MOLECULAR GENETICS

 -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons

(2015) M. Zaltieri et al.   JOURNAL OF CELL SCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure

(2015) Laura Navarria et al.   NEUROCHEMISTRY INTERNATIONAL

Colonic mucosal  -synuclein lacks specificity as a biomarker for Parkinson disease

(2015) N. P. Visanji et al.   NEUROLOGY

Drift in centrality of different brain regions in an anatomical neural network with Parkinson’s disease: A view from complex network analysis

(2015) X. Lei et al.   NEUROSCIENCE

α-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca2+ influx upon NMDA stimulation

(2015) Y. Chen et al.   NEUROSCIENCE

MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease

(2015) Jianli Wang et al.   PARKINSONISM & RELATED DISORDERS

Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of intrinsic brain activity

(2015) Jiuquan Zhang et al.   PARKINSONISM & RELATED DISORDERS

Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

(2015) Niklas K. U. Koehler et al.   PLoS One

Impaired intracellular trafficking defines early Parkinson's disease

(2015) Benjamin H.M. Hunn et al.   TRENDS IN NEUROSCIENCES

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson’s Disease

(2015) Maria Graciela Cersosimo   Gastroenterology Research and Practice

The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences

(2015) Michael Fauth et al.   PLoS Computational Biology

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

(2015) Scarlet Gallegos et al.   Frontiers in Neuroscience

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein

(2015) Cristine Betzer et al.   PLoS One

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease

(2015) Anke A. Dijkstra et al.   PLoS One

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Neurobiological correlates of depressive symptoms in people with subjective and mild cognitive impairment

(2014) E. Auning et al.   ACTA PSYCHIATRICA SCANDINAVICA

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

(2014) Gabrielle R. Wilson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson Disease Progression in the DATATOP Cohort

(2014) Tessandra Stewart et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding

(2014) Ying Lai et al.   BIOCHEMISTRY

Greater Loss of White Matter Integrity in Postural Instability and Gait Difficulty Subtype of Parkinson's Disease

(2014) Quanquan Gu et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Resting State Functional Magnetic Resonance Imaging in Parkinson’s Disease

(2014) Janey Prodoehl et al.   Current Neurology and Neuroscience Reports

The small GTPase Rab11 co-localizes with  -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

(2014) O. Chutna et al.   HUMAN MOLECULAR GENETICS

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour

(2014) Carlo Breda et al.   HUMAN MOLECULAR GENETICS

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N

(2014) L. N. Munsie et al.   HUMAN MOLECULAR GENETICS

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

(2014) Dayne A. Beccano-Kelly et al.   HUMAN MOLECULAR GENETICS

Rab-mediated trafficking role in neurite formation

(2014) David Villarroel-Campos et al.   JOURNAL OF NEUROCHEMISTRY

Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson’s disease

(2014) Yaroslau Compta et al.   JOURNAL OF NEUROLOGY

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

(2014) C. Pifl et al.   JOURNAL OF NEUROSCIENCE

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

(2014) D. Games et al.   JOURNAL OF NEUROSCIENCE

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(2014) G. Piccoli et al.   MOLECULAR AND CELLULAR BIOLOGY

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

(2014) Anke A. Dijkstra et al.   MOVEMENT DISORDERS

Abnormal functional connectivity of the amygdala is associated with depression in Parkinson's disease

(2014) Xiao Hu et al.   MOVEMENT DISORDERS

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

(2014) Jun-Shiao Chou et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

(2014) Guowei Yin et al.   NEUROBIOLOGY OF DISEASE

Visualization of nigrosome 1 and its loss in PD: Pathoanatomical correlation and in vivo 7T MRI

(2014) C. Mueller et al.   NEUROLOGY

Skin nerve  -synuclein deposits: A biomarker for idiopathic Parkinson disease

(2014) V. Donadio et al.   NEUROLOGY

Submandibular gland needle biopsy for the diagnosis of Parkinson disease

(2014) C. H. Adler et al.   NEUROLOGY

Functional connectivity in the basal ganglia network differentiates PD patients from controls

(2014) K. Szewczyk-Krolikowski et al.   NEUROLOGY

Strengthening Connections: Functional Connectivity and Brain Plasticity

(2014) Clare Kelly et al.   NEUROPSYCHOLOGY REVIEW

Generating bursts (and pauses) in the dopamine midbrain neurons

(2014) C.A. Paladini et al.   NEUROSCIENCE

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

(2014) Gergely Tóth et al.   PLoS One

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors

(2014) Fernando J. Bustos et al.   PLoS One

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

(2014) Daniel Rial et al.   PLoS One

Alpha-synuclein spreading in Parkinson’s disease

(2014) Ariadna Recasens et al.   Frontiers in Neuroanatomy

LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

(2014) Hui-Fang Liu et al.   Annals of Clinical and Translational Neurology

Structural plasticity of dendritic spines: The underlying mechanisms and its dysregulation in brain disorders

(2013) Kwok-On Lai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures

(2013) Catharine E. Krebs et al.   HUMAN MUTATION

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity

(2013) Robert H. C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mind the gut: secretion of α-synuclein by enteric neurons

(2013) Stefan A. Grathwohl et al.   JOURNAL OF NEUROCHEMISTRY

Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling

(2013) K. Zhang et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones

(2013) Angela R. Wild et al.   JOURNAL OF PHYSIOLOGY-LONDON

PINK1heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity

(2013) Graziella Madeo et al.   MOVEMENT DISORDERS

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study

(2013) ChunYan Luo et al.   NEUROBIOLOGY OF AGING

Quantification of α-synuclein in cerebrospinal fluid: How ideal is this biomarker for Parkinson's disease?

(2013) Brit Mollenhauer   PARKINSONISM & RELATED DISORDERS

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy

(2013) Malin Wennström et al.   PLoS One

Enhanced Functional Connectivity between Putamen and Supplementary Motor Area in Parkinson’s Disease Patients

(2013) Rongjun Yu et al.   PLoS One

The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

(2013) Eleftheria K. Pissadaki et al.   Frontiers in Computational Neuroscience

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Resting-state functional connectivity as a marker of disease progression in Parkinson's disease: A longitudinal MEG study

(2013) Kim T.E. Olde Dubbelink et al.   NeuroImage-Clinical

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

(2013) Nady Braidy et al.   Translational Neurodegeneration

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

(2012) Eric C. Freundt et al.   ANNALS OF NEUROLOGY

Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein

(2012) Eun-Jin Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Resting state functional connectivity of the striatum in Parkinson’s disease

(2012) Carl D. Hacker et al.   BRAIN

Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease

(2012) Kavita Prasad et al.   BRAIN PATHOLOGY

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease

(2012) Min Jeong Park et al.   Journal of Clinical Neurology

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Cognitive impairment and dementia in Parkinson's disease

(2012) Javier Pagonabarraga et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein Genetic Variants Predict Faster Motor Symptom Progression in Idiopathic Parkinson Disease

(2012) Beate Ritz et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death

(2011) Furong Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

DJ-1 associates with synaptic membranes

(2011) Yukiko Usami et al.   NEUROBIOLOGY OF DISEASE

Parkinson’s disease: The non-motor issues

(2011) K. Ray Chaudhuri et al.   PARKINSONISM & RELATED DISORDERS

Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

(2011) Wilma D.J. van de Berg et al.   PARKINSONISM & RELATED DISORDERS

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease

(2011) Arianna Bellucci et al.   PLoS One

Imaging biomarkers in Parkinson's disease

(2011) David J. Brooks et al.   PROGRESS IN NEUROBIOLOGY

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

(2010) Walter J. Schulz-Schaeffer   ACTA NEUROPATHOLOGICA

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

(2010) Pablo Garcia-Reitböck et al.   BRAIN

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Synapsins Differentially Control Dopamine and Serotonin Release

(2010) B. M. Kile et al.   JOURNAL OF NEUROSCIENCE

Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of  1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells

(2010) R. Eva et al.   JOURNAL OF NEUROSCIENCE

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Occurrence of depression and anxiety prior to Parkinson’s disease

(2010) E.L. Jacob et al.   PARKINSONISM & RELATED DISORDERS

White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study

(2009) G. Gattellaro et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The progression of pathology in Parkinson's disease

(2009) Glenda Margaret Halliday et al.   Annals of the New York Academy of Sciences

α-Synuclein Gene Rearrangements in Dominantly Inherited Parkinsonism

(2009) Pablo Ibáñez   ARCHIVES OF NEUROLOGY

A clinico-pathological study of subtypes in Parkinson's disease

(2009) M. Selikhova et al.   BRAIN

Activity-dependent structural plasticity

(2009) Markus Butz et al.   BRAIN RESEARCH REVIEWS

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Rab11a and HSP90 Regulate Recycling of Extracellular  -Synuclein

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Uncoupling Dendrite Growth and Patterning: Single-Cell Knockout Analysis of NMDA Receptor 2B

(2009) J. Sebastian Espinosa et al.   NEURON

Neuropathology of non-motor features of Parkinson disease

(2009) Dennis W. Dickson et al.   PARKINSONISM & RELATED DISORDERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controversies over the staging of α-synuclein pathology in Parkinson’s disease

(2008) Michail E. Kalaitzakis et al.   ACTA NEUROPATHOLOGICA

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

(2008) Filip Simunovic et al.   BRAIN

Parkinson patient fibroblasts show increased alpha-synuclein expression

(2008) Hans-Hermann Hoepken et al.   EXPERIMENTAL NEUROLOGY

Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2D3receptor activation

(2008) Arianna Bellucci et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Principles of Long-Term Dynamics of Dendritic Spines

(2008) N. Yasumatsu et al.   JOURNAL OF NEUROSCIENCE

Nigral burden of α-synuclein correlates with striatal dopamine deficit

(2008) Gabor G. Kovacs et al.   MOVEMENT DISORDERS

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Neue Sicht des kortiko-striato-thalamo-kortikalen Regelkreises bei M. Parkinson

(2008) H. Braak et al.   NERVENARZT

Dementia and survival in Parkinson disease: A 12-year population study

(2008) T. C. Buter et al.   NEUROLOGY

DJ-1 is Essential for Long-Term Depression at Hippocampal CA1 Synapses

(2008) Yue Wang et al.   NEUROMOLECULAR MEDICINE

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC