Review
Nutrition & Dietetics
Theodora Nikou, Maria Eleni Sakavitsi, Evangelos Kalampokis, Maria Halabalaki
Summary: This critical review gathers scientific data from the past two decades on the absorption and metabolism of key olive compounds, with a focus on phenylalcohols and secoiridoids. The review highlights the existing knowledge and lack of data, and provides insights for future research approaches in exploring the bioavailability and metabolism of olive compounds.
Review
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Maria D. Navarro-Hortal, Rosa Quirantes-Pine, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sanchez-Gonzalez, Maurizio Battino, Jose L. Quiles
Summary: Alzheimer's Disease (AD) is a major cause of global dementia cases, affecting around 50 million people worldwide. The leaves of olive trees contain bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT), which have shown medicinal properties in fighting AD. Olive leaf (OL), OLE, and HT can reduce amyloid-beta and neurofibrillary tangles formation, and OL has exhibited high cholinergic inhibitory activity. These compounds may also decrease neuroinflammation and oxidative stress, potentially promoting autophagy and restoring loss of proteostasis in AD models. Therefore, olive phytochemicals hold promise as an adjuvant in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Hidayat Ur Rahman, Muhammad Hamdi Mahmood, Najm Us Sama, Muhammad Afzal, Mohd Razip Asaruddin, Mohammed Safwan Ali Khan
Summary: The study found that major phenolic compounds in olive oil may have potential anti-inflammatory and analgesic properties, and identified other phytochemicals that could be used for pain relief and anti-inflammatory activity.
JOURNAL OF OLEO SCIENCE
(2022)
Review
Agriculture, Multidisciplinary
Beatriz T. Martins, Maria Rosario Bronze, M. Rita Ventura
Summary: Virgin olive oil is the main fat consumed in the Mediterranean basin, and its phenolic compounds are known to have health benefits. The low concentrations and limited availability of commercial standards for these compounds have hindered studies on their biological activity. Chemical synthesis is considered a convenient method for obtaining these compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alvaro Hernaez, Sara Jaramillo, Aranzazu Garcia-Borrego, Juan Antonio Espejo-Calvo, Maria-Isabel Covas, Gemma Blanchart, Rafael de la Torre, Alegria Carrasco-Pancorbo, Maria Dolores Mesa, Maria Africa Fernandez-Prior, Olga Castaner, Montserrat Fito
Summary: The combination of specific olive tree-related extracts showed the best in vitro bioactive properties, particularly at nutritional and nutraceutical doses, for preparing functional products and nutraceuticals with cardioprotective properties. Despite individual extracts showing high in vitro properties, there may be a potential synergistic effect among different olive components in the combination.
Article
Biochemistry & Molecular Biology
Flora V. Romeo, Gina Granuzzo, Paola Foti, Gabriele Ballistreri, Cinzia Caggia, Paolo Rapisarda
Summary: This study aimed to increase the hydroxytyrosol content in olive mill wastewater (OMW) extract by microbial enzymatic activity. Results showed that W. anomalus strain and SP207 resin demonstrated the best performance in this process.
Review
Nutrition & Dietetics
Arindam Sain, Sakshi Sahu, Debdut Naskar
Summary: Phenolic compounds in olive oil have shown potential activities against CRC by reducing proliferation, migration, invasion, and angiogenesis through regulation of various signaling pathways, as well as inducing apoptosis in different CRC models. Further research is needed to establish these compounds as nutritional supplements and develop therapeutic strategies for CRC.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Maria Rita Emma, Giuseppa Augello, Vita Di Stefano, Antonina Azzolina, Lydia Giannitrapani, Giuseppe Montalto, Melchiorre Cervello, Antonella Cusimano
Summary: The Mediterranean diet is rich in antioxidants and anti-inflammatory nutrients, with extra-virgin olive oil playing a key role due to its phenolic compounds and secoiridoids. These compounds have been shown to have antioxidant, anti-inflammatory, and anti-proliferative properties, which contribute to their anti-cancer activity. The review summarizes the pharmacological properties, molecular targets, and action mechanisms of secoiridoids, with a focus on their potential use in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Andres Jimenez-Sanchez, Antonio Jesus Martinez-Ortega, Pablo Jesus Remon-Ruiz, Ana Pinar-Gutierrez, Jose Luis Pereira-Cunill, Pedro Pablo Garcia-Luna
Summary: This narrative review synthesizes and illustrates the characteristics and clinical applications of extra virgin olive oil (EVOO) and its components in the field of clinical nutrition and dietetics. EVOO has diverse health properties and can be used in diet therapy and as a supplement to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus. However, more research is needed to provide specific recommendations for its therapeutic use in different diseases and populations.
Article
Green & Sustainable Science & Technology
Gabriela Silveira da Rosa, Thamiris Renata Martiny, Guilherme Luiz Dotto, Sai Kranthi Vanga, Debora Parrine, Yvan Gariepy, Mark Lefsrud, Vijaya Raghavan
Summary: The study demonstrates that green technologies are suitable for extracting bioactive compounds from Brazilian olive tree leaves, with microwave-assisted extraction being the most efficient method and oleuropein being the predominant phenolic compound in the extracts.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Maria Cristina Caroleo, Pierluigi Plastina, Alessia Fazio, Chiara La Torre, Fabrizio Manetti, Erika Cione
Summary: The study focused on the potential effects of natural lipophenols on insulin secretion in type 2 diabetes mellitus, and their role in modulating the FFAR1 receptor. The findings suggest that these compounds may play a role in the anti-diabetic properties associated with olive oil consumption.
Review
Nutrition & Dietetics
Paula Silva, Maria Rodriguez-Perez, Oscar Gomez-Torres, Emma Burgos-Ramos
Summary: This study reviews the protective effect of polyphenolic compounds from extra virgin olive oil and wine in Alzheimer's disease (AD) and emphasizes that they could be potential therapeutic tools. Polyphenols have beneficial effects in beta-aggregation, neurofibrillary tangles, autophagy, mitochondrial function, and cerebral insulin resistance. Additionally, no harmful dose has been identified.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Nutrition & Dietetics
Annalisa Noce, Giulia Marrone, Silvia Urciuoli, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Nicola Di Daniele, Annalisa Romani
Summary: The Mediterranean diet with extra virgin olive oil appears beneficial for patients with chronic kidney disease, improving renal function, reducing oxidative stress and inflammation, enhancing body composition, with more significant and long-lasting effects observed in those consuming high MPC EVOO content.
Article
Biochemistry & Molecular Biology
Aurelia Malapert, Emmanuelle Reboul, Olivier Dangles, Alain Thiery, N'nabinty Sylla, Valerie Tomao
Summary: A new simple and eco-friendly extraction process has been developed using native beta-cyclodextrin to remove phenolic compounds from olive mill waste water, achieving high extraction efficiency and loading capacity. The study found that the phenols encapsulated in solid beta-cyclodextrin are protected against photodegradation, making it a potential safe-grade food supplement.
Review
Nutrition & Dietetics
Kok-Lun Pang, Johanna Nathania Lumintang, Kok-Yong Chin
Summary: Olive derivatives, especially olive oil and leaf extract, may stimulate thyroid function, showing thyroid-stimulating activities in euthyroid or hypothyroid animals. However, validation of their beneficial health effects in the human population is lacking.
Article
Endocrinology & Metabolism
Rosaria Maddalena Ruggeri, Salvatore Giovinazzo, Maria Cristina Barbalace, Mariateresa Cristani, Angela Alibrandi, Teresa M. Vicchio, Giuseppe Giuffrida, Mohamed H. Aguennouz, Marco Malaguti, Cristina Angeloni, Francesco Trimarchi, Silvana Hrelia, Alfredo Campenni, Salvatore Cannavo
Summary: The study found that individuals with Hashimoto's thyroiditis had higher intake frequencies of animal foods compared to controls, while controls reported higher intake frequencies of plant foods. Meat consumption was associated with increased odds of developing thyroid autoimmunity, while adherence to Mediterranean diet traits was protective. In Hashimoto's thyroiditis subjects, markers of oxidative stress were significantly higher and antioxidant activity was lower, indicating a condition of oxidative stress.
Article
Biochemistry & Molecular Biology
Maria Cristina Barbalace, Lorenzo Zallocco, Daniela Beghelli, Maurizio Ronci, Serena Scortichini, Maria Digiacomo, Marco Macchia, Maria Rosa Mazzoni, Dennis Fiorini, Antonio Lucacchini, Silvana Hrelia, Laura Giusti, Cristina Angeloni
Summary: Phenols in extra-virgin olive oil have neuroprotective effects, with specific outcomes related to geographical origin and phenol composition.
Article
Cell Biology
Daniela Beghelli, Lorenzo Zallocco, Maria Cristina Barbalace, Simona Paglia, Silvia Strocchi, Ilenia Cirilli, Valeria Marzano, Lorenza Putignani, Giulio Lupidi, Silvana Hrelia, Laura Giusti, Cristina Angeloni
Summary: The study found that supplementation of pterostilbene can extend the lifespan of fruit flies, with different effects in males and females. Pterostilbene seems to increase the lifespan of both male and female fruit flies through different mechanisms.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Paulina Roux-Biejat, Marco Coazzoli, Pasquale Marrazzo, Silvia Zecchini, Ilaria Di Renzo, Cecilia Prata, Alessandra Napoli, Claudia Moscheni, Matteo Giovarelli, Maria Cristina Barbalace, Elisabetta Catalani, Maria Teresa Bassi, Clara De Palma, Davide Cervia, Marco Malaguti, Silvana Hrelia, Emilio Clementi, Cristiana Perrotta
Summary: The acid sphingomyelinase (ASMase) plays a crucial role in skeletal muscle regeneration by regulating the balance between M1 and M2 macrophages in the injured muscles, reducing inflammation and accelerating the early phases of muscle regeneration. This study reveals a novel function of ASMase in modulating the immune response during muscle repair and suggests ASMase as a potential therapeutic target to improve muscle recovery in conditions with excessive inflammation.
Article
Biochemistry & Molecular Biology
Andrea Spinaci, Catia Lambertucci, Michela Buccioni, Diego Dal Ben, Claudia Graiff, Maria Cristina Barbalace, Silvana Hrelia, Cristina Angeloni, Seyed Khosrow Tayebati, Massimo Ubaldi, Alessio Masi, Karl-Norbert Klotz, Rosaria Volpini, Gabriella Marucci
Summary: In this study, two series of compounds based on purine and triazolotriazine scaffolds were synthesized to find novel ligands for the A(2A) adenosine receptor (A(2A)AR). It was found that some compounds had high affinity for A(2A)AR and that compound 13 exhibited anti-inflammatory properties in microglial cells. Molecular modeling studies supported the binding affinity data and revealed that substitution at specific positions is necessary for interchangeability between triazolotriazine and purine scaffolds.
Review
Biochemistry & Molecular Biology
Cristiana Caliceti, Marco Malaguti, Luisa Marracino, Maria Cristina Barbalace, Paola Rizzo, Silvana Hrelia
Summary: This article summarizes the potential use of waste or by-products derived from the processing of traditional Italian crops (apple, pear, and sugar beet) as a source of bioactive molecules to protect endothelial function. The waste matrices of these crops have the potential to be used as starting materials for producing upcycled products with functional applications, such as the prevention of endothelial dysfunction associated with cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Cristina Angeloni, Marco Malaguti, Cecilia Prata, Michela Freschi, Maria Cristina Barbalace, Silvana Hrelia
Summary: Neurodegenerative diseases are increasingly prevalent with aging population. They are multifactorial disorders with common mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress and inflammation. Plant-derived compounds from food and agrifood by-products have potential neuroprotective activities and recycling food waste is important. This review focuses on the potential neuroprotective activity of agrifood wastes from widely consumed products in Italy.
Editorial Material
Biochemistry & Molecular Biology
Silvana Hrelia, Cristina Angeloni, Maria Cristina Barbalace
Article
Biochemistry & Molecular Biology
Pasquale Marrazzo, Manuela Mandrone, Ilaria Chiocchio, Laura Zambonin, Maria Cristina Barbalace, Chiara Zalambani, Cristina Angeloni, Marco Malaguti, Cecilia Prata, Ferruccio Poli, Diana Fiorentini, Silvana Hrelia
Summary: Studies have shown that chestnut leaf and spiny bur extracts have good anti-neuroinflammatory effects, with chestnut leaf extract being more effective than spiny bur extract. The phytochemical characterization of leaf extracts revealed the presence of specific flavonoids and unsaturated fatty acids, which are likely responsible for the observed anti-neuroinflammatory effects. Exploiting chestnut by-products can satisfy consumers' demand for new natural bioactive compounds and also valorize the by-products.
Review
Nutrition & Dietetics
Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Laura Croce, Marco Malaguti, Alfredo Campenni, Mario Rotondi, Salvatore Cannavo, Silvana Hrelia
Summary: Autoimmune thyroid diseases are increasing rapidly worldwide due to environmental factors related to changed lifestyles. Unhealthy high-energy diets negatively affect autoimmunity, while the Mediterranean diet positively influences immune system function, gut microbiota composition, and redox homeostasis.
Article
Health Care Sciences & Services
Agata Zirilli, Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Silvana Hrelia, Luca Giovanella, Alfredo Campenni, Salvatore Cannavo, Angela Alibrandi
Summary: This study aimed to assess the differences in oxidative stress markers between omnivorous and semi-vegetarian dietary regimes. The findings indicate that semi-vegetarians have higher levels of antioxidant parameters (GPx and TRxR) and lower levels of AGE and AOPP markers compared to omnivorous individuals, particularly in females, different age groups, those with normal weight, and those not affected by Hashimoto's thyroiditis.
Meeting Abstract
Biochemistry & Molecular Biology
M. Freschi, M. C. Barbalace, E. Spinozzi, V. Scocco, G. Bonacucina, C. Angeloni, S. Hrelia
Meeting Abstract
Biochemistry & Molecular Biology
M. C. Barbalace, M. Freschi, V. Scocco, C. Lambertucci, S. Hrelia, C. Angeloni
