Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology

Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?

(2017) Kevin J. Cyr et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques

(2017) Christopher Barry et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Programming microphysiological systems for children’s health protection

(2017) TB Knudsen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Self-contained, low-cost Body-on-a-Chip systems for drug development

(2017) Ying I Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Gastrointestinal microphysiological systems

(2017) Sarah E Blutt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microphysiologic systems in female reproductive biology

(2017) Alexandria N Young et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

(2017) Sean P Sheehy et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems

(2017) Alejandro Soto-Gutierrez et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

(2017) David J Hughes et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Next generation human skin constructs as advanced tools for drug development

(2017) HE Abaci et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action

(2017) Jeremy L. Norris et al.   JOURNAL OF PROTEOME RESEARCH

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

(2017) Karel Domansky et al.   Microfluidics and Nanofluidics

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Physiologically relevant human tissue models for infectious diseases

(2016) Melody Mills et al.   DRUG DISCOVERY TODAY

Tissue-Engineering for the Study of Cardiac Biomechanics

(2016) Stephen P. Ma et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

(2016) Onur Kilic et al.   LAB ON A CHIP

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

(2016) Jingtao Lu et al.   PLoS Computational Biology

Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

(2016) Jeffrey J. Sutherland et al.   PLoS Computational Biology

Building the drains: the lymphatic vasculature in health and disease

(2016) Marina Venero Galanternik et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Organ-On-A-Chip: Development and Clinical Prospects Toward Toxicity Assessment with an Emphasis on Bone Marrow

(2015) Jeehye Kim et al.   DRUG SAFETY

Fluorescent protein biosensors applied to microphysiological systems

(2015) Nina Senutovitch et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Biology coming full circle: Joining the whole and the parts

(2015) John P Wikswo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

In vitro micro-physiological models for translational immunology

(2015) Qasem Ramadan et al.   LAB ON A CHIP

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

Gecko gaskets for self-sealing and high-strength reversible bonding of microfluidics

(2015) A. Wasay et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

(2015) Nathaniel Huebsch et al.   TISSUE ENGINEERING PART C-METHODS

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Human immunity in vitro — Solving immunogenicity and more

(2014) Christoph Giese et al.   ADVANCED DRUG DELIVERY REVIEWS

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Of human-on-a-chip and humans: Considerations for creating and using microphysiological systems

(2014) William Slikker   EXPERIMENTAL BIOLOGY AND MEDICINE

Microscale technologies for regulating human stem cell differentiation

(2014) Elisa Cimetta et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

(2014) Kira G Hartman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Physiology and metabolism of tissue-engineered skeletal muscle

(2014) Cindy S Cheng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Challenges and promises in modeling dermatologic disorders with bioengineered skin

(2014) Narat J Eungdamrong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Human enteroids as an ex-vivo model of host–pathogen interactions in the gastrointestinal tract

(2014) Jennifer Foulke-Abel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases

(2014) Peter G Alexander et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

(2014) Christopher Heylman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microphysiological modeling of the reproductive tract: A fertile endeavor

(2014) Sharon L Eddie et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A microphysiological system model of therapy for liver micrometastases

(2014) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

In vitro platforms for evaluating liver toxicity

(2014) Shyam Sundhar Bale et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Biological and medical applications of a brain-on-a-chip

(2014) David Pamies et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

(2014) Joan E Nichols et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

(2014) Danica B Stanimirovic et al.   Expert Opinion on Drug Discovery

An extracorporeal blood-cleansing device for sepsis therapy

(2014) Joo H Kang et al.   NATURE MEDICINE

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Simple, Low-Cost Styrene-Ethylene/Butylene-Styrene Microdevices for Electrokinetic Applications

(2013) Mark D. Borysiak et al.   ANALYTICAL CHEMISTRY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Simple replica micromolding of biocompatible styrenic elastomers

(2013) Mark D. Borysiak et al.   LAB ON A CHIP

Microfluidic transwell inserts for generation of tissue culture-friendly gradients in well plates

(2013) Christopher G. Sip et al.   LAB ON A CHIP

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Brain slice on a chip: opportunities and challenges of applying microfluidic technology to intact tissues

(2012) Yu Huang et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

Precise Spatial and Temporal Control of Oxygen within In Vitro Brain Slices via Microfluidic Gas Channels

(2012) Gerardo Mauleon et al.   PLoS One

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes

(2010) Alexander J. Blake et al.   JOURNAL OF NEUROSCIENCE METHODS

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Culturing thick brain slices: An interstitial 3D microperfusion system for enhanced viability

(2009) Komal Rambani et al.   JOURNAL OF NEUROSCIENCE METHODS

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

Chamber and microfluidic probe for microperfusion of organotypic brain slices

(2009) Arthur Queval et al.   LAB ON A CHIP

A Combined Pharmacokinetic–Pharmacodynamic (PK–PD) Model for Tumor Growth in the Rat with UFT Administration

(2008) Jong Hwan Sung et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microfluidic add-on for standard electrophysiology chambers

(2008) Javeed Shaikh Mohammed et al.   LAB ON A CHIP

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS