Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Machine learning identifies a compact gene set for monitoring the circadian clock in human blood

(2017) Jacob J. Hughey   Genome Medicine

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reverse Engineering Human Pathophysiology with Organs-on-Chips

(2016) Donald E. Ingber   CELL

Circadian Clock Control of Liver Metabolic Functions

(2016) Hans Reinke et al.   GASTROENTEROLOGY

The Liver in the Eyes of a Chronobiologist

(2016) Ziv Zwighaft et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal

(2016)   MOLECULES AND CELLS

ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system

(2016) Jacob J. Hughey et al.   NUCLEIC ACIDS RESEARCH

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health

(2016) Aleix Ribas-Latre et al.   Molecular Metabolism

Circadian CLOCK Mediates Activation of Transforming Growth Factor-β Signaling and Renal Fibrosis through Cyclooxygenase 2

(2015) Wei-Dar Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Influence of circadian disruption on neurotransmitter levels, physiological indexes, and behaviour in rats

(2015) Takeru Matsumura et al.   CHRONOBIOLOGY INTERNATIONAL

Transcriptional control of circadian metabolic rhythms in the liver

(2015) S. Li et al.   DIABETES OBESITY & METABOLISM

Biology coming full circle: Joining the whole and the parts

(2015) John P Wikswo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

‘Organs-on-chips’ go mainstream

(2015) Sara Reardon   NATURE

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

(2015) Rita Barandas et al.   Current Psychiatry Reports

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle

(2015) Kenneth A. Dyar et al.   Molecular Metabolism

Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform

(2015) Christina C. Marasco et al.   PLoS One

Of human-on-a-chip and humans: Considerations for creating and using microphysiological systems

(2014) William Slikker   EXPERIMENTAL BIOLOGY AND MEDICINE

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases

(2014) Peter G Alexander et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microphysiological modeling of the reproductive tract: A fertile endeavor

(2014) Sharon L Eddie et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A microphysiological system model of therapy for liver micrometastases

(2014) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

(2014) Joan E Nichols et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Continuous 24-Hour Leptin, Proopiomelanocortin, and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin, Soluble Leptin Receptor, and Amino Acid Levels

(2014) Sharon L. Wardlaw et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

(2014) Jacquelyn A Brown et al.   Journal of Neuroinflammation

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Circadian clock control of endocrine factors

(2014) Karen L. Gamble et al.   Nature Reviews Endocrinology

Circadian glomerular function: from physiology to molecular and therapeutical aspects

(2014) G. Wuerzner et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

(2014) Brian P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multichamber multipotentiostat system for cellular microphysiometry

(2014) Eduardo A. Lima et al.   SENSORS AND ACTUATORS B-CHEMICAL

Sex bias exists in basic science and translational surgical research

(2014) Dustin Y. Yoon et al.   SURGERY

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

(2014) Aurelie Vivares et al.   XENOBIOTICA

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

(2014) David Basketter   ALTEX-Alternatives to Animal Experimentation

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

(2013) Christopher B. Forsyth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening

(2013) Jong Bum Lee et al.   Biotechnology Journal

Role of hypothalamic corticotropin-releasing factor in mediating alcohol-induced activation of the rat hypothalamic–pituitary–adrenal axis

(2013) Catherine Rivier   FRONTIERS IN NEUROENDOCRINOLOGY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Metabolism and the Circadian Clock Converge

(2013) Kristin Eckel-Mahan et al.   PHYSIOLOGICAL REVIEWS

The Circadian Variation in Anti-Müllerian Hormone in Patients with Polycystic Ovary Syndrome Differs Significantly from Normally Ovulating Women

(2013) Leif Bungum et al.   PLoS One

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

How Do Control-Based Approaches Enter into Biology?

(2011) Philip R LeDuc et al.   Annual Review of Biomedical Engineering

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

(2011) Sooyoung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

(2011) H. Yu et al.   CLINICAL CHEMISTRY

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

The role of circadian timing system on drug metabolism and detoxification

(2010) Frédéric Gachon et al.   Expert Opinion on Drug Metabolism & Toxicology

Modeling the measurements of cellular fluxes in microbioreactor devices using thin enzyme electrodes

(2010) Momchil Velkovsky et al.   JOURNAL OF MATHEMATICAL CHEMISTRY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Body-on-a chip: Using microfluidic systems to predict human responses to drugs

(2010) Michael L. Shuler et al.   PURE AND APPLIED CHEMISTRY

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Distilling Free-Form Natural Laws from Experimental Data

(2009) Michael Schmidt et al.   SCIENCE

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

A logic-based diagram of signalling pathways central to macrophage activation

(2008) Sobia Raza et al.   BMC Systems Biology

The influence of circadian rhythms on the kinetics of drugs in humans

(2008) Massimo Baraldo   Expert Opinion on Drug Metabolism & Toxicology

Free Triiodothyronine Has a Distinct Circadian Rhythm That Is Delayed but Parallels Thyrotropin Levels

(2008) W. Russell et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment

(2008) W. Kim et al.   PHARMACOLOGICAL REVIEWS

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

(2008) S PANDIPERUMAL et al.   PROGRESS IN NEUROBIOLOGY

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS