Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain in Vivo Fluorescence Imaging

(2018) Abedelnasser Abulrob et al.   Molecular Imaging

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

(2014) Roxann Freeman et al.   BRAIN RESEARCH

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Quantitative targeted proteomics for understanding the blood–brain barrier: towards pharmacoproteomics

(2014) Sumio Ohtsuki et al.   Expert Review of Proteomics

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering

(2014) Yuan Wang et al.   JOURNAL OF DRUG TARGETING

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

(2014) Irena Loryan et al.   PHARMACEUTICAL RESEARCH

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes

(2014) Julie Boyer-Di Ponio et al.   PLoS One

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Zebrafish models for translational neuroscience research: from tank to bedside

(2014) Adam Michael Stewart et al.   TRENDS IN NEUROSCIENCES

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1In Vitroand Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration

(2013) Pedro Miguel Salcedo Gómez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box

(2013) Luca Cucullo et al.   BMC NEUROSCIENCE

Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier

(2013) P Marc D Watson et al.   BMC NEUROSCIENCE

‘Sealing off the CNS’: cellular and molecular regulation of blood–brain barriergenesis

(2013) Julie A Siegenthaler et al.   CURRENT OPINION IN NEUROBIOLOGY

Retinoic Acid Induces Blood-Brain Barrier Development

(2013) M. R. Mizee et al.   JOURNAL OF NEUROSCIENCE

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

(2013) Daniel J. Wolak et al.   MOLECULAR PHARMACEUTICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

(2013) Roberta Paolinelli et al.   PLoS One

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Zebrafish approaches enhance the translational research tackle box

(2013) Michael A. Pickart et al.   Translational Research

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

(2012) Kohei Watanabe et al.   BMC NEUROSCIENCE

Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

(2012) Adjanie Patabendige et al.   BRAIN RESEARCH

Zebrafish as a Model to Study Drug Transporters at the Blood–Brain Barrier

(2012) R A Umans et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity

(2012) Omolara O. Ogunshola   CURRENT PHARMACEUTICAL DESIGN

Imaging blood-brain barrier dysfunction in animal disease models

(2012) Andreas Wunder et al.   EPILEPSIA

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models

(2012) Éva Hellinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

CNS Drug Development – Lost in Translation?

(2012) A. Talevi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method

(2012) Arsalan S. Haqqani et al.   MOLECULAR PHARMACEUTICS

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Galanin Transgenic Mice with Elevated Circulating Galanin Levels Alleviate Demyelination in a Cuprizone-Induced MS Mouse Model

(2012) Lin Zhang et al.   PLoS One

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood–brain barrier permeability?

(2011) Alex Avdeef   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila

(2011) Michael K. Desalvo et al.   GLIA

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Claudin-5a in developing zebrafish brain barriers: another brick in the wall

(2010) Salim Abdelilah-Seyfried   BIOESSAYS

Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors

(2010) Fumitaka Shimizu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Validation of In Vitro Cell-Based Human Blood−Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration

(2010) Aloïse Mabondzo et al.   MOLECULAR PHARMACEUTICS

Control of the Blood-Brain Barrier by Glucocorticoids and the Cells of the Neurovascular Unit

(2009) Susanne Kröll et al.   Annals of the New York Academy of Sciences

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

(2008) Jiunn Lin   CURRENT DRUG METABOLISM

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

(2008) Maxime Culot et al.   TOXICOLOGY IN VITRO