The relevance and potential roles of microphysiological systems in biology and medicine

Multianalyte Microphysiometry Reveals Changes in Cellular Bioenergetics Upon Exposure to Fluorescent Dyes

(2013) Tesniem F. Shinawi et al.   ANALYTICAL CHEMISTRY

Application of multianalyte microphysiometry to characterize macrophage metabolic responses to oxidized LDL and effects of an apoA-1 mimetic

(2013) Danielle W. Kimmel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacology on microfluidics: multimodal analysis for studying cell–cell interaction

(2013) Emmanuel Delamarche et al.   CURRENT OPINION IN PHARMACOLOGY

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Organs on Chips 2013

(2013) David J. Beebe et al.   LAB ON A CHIP

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

(2013) Mingjian Shi et al.   LAB ON A CHIP

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Metabolic Multianalyte Microphysiometry Reveals Extracellular Acidosis is an Essential Mediator of Neuronal Preconditioning

(2012) Jennifer R. McKenzie et al.   ACS Chemical Neuroscience

A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry

(2012) Jeffrey R. Enders et al.   ANALYTICAL CHEMISTRY

Metabolic Impact of 4-Hydroxynonenal on Macrophage-Like RAW 264.7 Function and Activation

(2012) Reese S. Harry et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Point of Care Diagnostics: Status and Future

(2011) Vladimir Gubala et al.   ANALYTICAL CHEMISTRY

Electrochemical Sensors and Biosensors

(2011) Danielle W. Kimmel et al.   ANALYTICAL CHEMISTRY

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

How Do Control-Based Approaches Enter into Biology?

(2011) Philip R LeDuc et al.   Annual Review of Biomedical Engineering

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Optogenetic Control of Cells and Circuits

(2011) Gero Miesenböck   Annual Review of Cell and Developmental Biology

A printed superoxide dismutase coated electrode for the study of macrophage oxidative burst

(2011) Leslie A. Hiatt et al.   BIOSENSORS & BIOELECTRONICS

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation

(2010) Stephanie L.H. Zeiger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The “hospital central laboratory”: automation, integration and clinical usefulness

(2010) Martina Zaninotto et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

Systems biology and integrative physiological modelling

(2010) Robert L. Hester et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

Body-on-a chip: Using microfluidic systems to predict human responses to drugs

(2010) Michael L. Shuler et al.   PURE AND APPLIED CHEMISTRY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

The Effects of Cholera Toxin on Cellular Energy Metabolism

(2010) Rachel M. Snider et al.   Toxins

Experiments and Observations

(2009) Howard Markel   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer

(2009) Sven Eklund et al.   SENSORS

Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel

(2008) Shannon Faley et al.   LAB ON A CHIP