In vitro micro-physiological models for translational immunology

A novel device to concurrently assess leukocyte extravasation and interstitial migration within a defined 3D environment

(2015) Raffaella Molteni et al.   LAB ON A CHIP

An immunohistochemical study and review of potential markers of human intestinal M cells

(2015) NACS Wong et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Bioreactor technologies to support liver function in vitro

(2014) Mohammad R. Ebrahimkhani et al.   ADVANCED DRUG DELIVERY REVIEWS

Human immunity in vitro — Solving immunogenicity and more

(2014) Christoph Giese et al.   ADVANCED DRUG DELIVERY REVIEWS

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

(2014) Richard Judson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Microchip-based engineering of super-pancreatic islets supported by adipose-derived stem cells

(2014) Yesl Jun et al.   BIOMATERIALS

The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries

(2014) M. Felder et al.   Integrative Biology

Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages

(2014) Se-Eun Jang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy

(2014) Nalini K. Vudattu et al.   JOURNAL OF IMMUNOLOGY

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

(2014) Jing Dong et al.   JOURNAL OF LIPID RESEARCH

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

Microfluidic single-cell analysis for systems immunology

(2014) Michael Junkin et al.   LAB ON A CHIP

Hepatic organoids for microfluidic drug screening

(2014) Sam H. Au et al.   LAB ON A CHIP

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation

(2014) Alexander Peyton Nesmith et al.   LAB ON A CHIP

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment

(2014) Yiming Niu et al.   MOLECULAR PHARMACEUTICS

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

On-chip investigation of cell–drug interactions

(2013) Xin Ting Zheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Animal models of human disease: Inflammation

(2013) David R. Webb   BIOCHEMICAL PHARMACOLOGY

Biomimetic tumor microenvironment on a microfluidic platform

(2013) Huipeng Ma et al.   Biomicrofluidics

Microfluidic culture models to study the hydrodynamics of tumor progression and therapeutic response

(2013) Cara Buchanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

Innate immunity

(2013) Jules Hoffmann et al.   CURRENT OPINION IN IMMUNOLOGY

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers

(2013) Else M. Frohlich et al.   LAB ON A CHIP

Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery

(2013) Wei Wang et al.   LAB ON A CHIP

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation: Mechanisms, Costs, and Natural Variation

(2012) Noah T. Ashley et al.   Annual Review of Ecology Evolution and Systematics

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

A novel microphysiometer based on high sensitivity LAPS and microfluidic system for cellular metabolism study and rapid drug screening

(2012) Ning Hu et al.   BIOSENSORS & BIOELECTRONICS

Modulation of tight junction integrity by food components

(2012) Agnieszka Kosińska et al.   FOOD RESEARCH INTERNATIONAL

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Escherichia coli UropathogenesisIn Vitro: Invasion, Cellular Escape, and Secondary Infection Analyzed in a Human Bladder Cell Infection Model

(2012) Thomas E. Andersen et al.   INFECTION AND IMMUNITY

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils

(2012) Sewoon Han et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

An integrated microfluidic cell culture system for high-throughput perfusion three-dimensional cell culture-based assays: effect of cell culture model on the results of chemosensitivity assays

(2012) Song-Bin Huang et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Oral exposure to polystyrene nanoparticles affects iron absorption

(2012) Gretchen J. Mahler et al.   Nature Nanotechnology

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCTC 2544 and IL-18 production: A tool for the identification of contact allergens

(2012) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency

(2012) Marc Teunis et al.   TOXICOLOGY IN VITRO

Relevance and challenges in modeling human gastric and small intestinal digestion

(2012) Aurélie Guerra et al.   TRENDS IN BIOTECHNOLOGY

Combined Experimental and Mathematical Approach for Development of Microfabrication-Based Cancer Migration Assay

(2011) Saheli Sarkar et al.   ANNALS OF BIOMEDICAL ENGINEERING

Inflammation-mediated obesity and insulin resistance as targets for nutraceuticals

(2011) Myung-Sunny Kim et al.   Annals of the New York Academy of Sciences

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration

(2011) Yu Huang et al.   Biomicrofluidics

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

'Gut health': a new objective in medicine?

(2011) Stephan C Bischoff   BMC Medicine

Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases

(2011) Paula Grammas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Interactions with M Cells and Macrophages as Key Steps in the Pathogenesis of Enterohemorragic Escherichia coli Infections

(2011) Lucie Etienne-Mesmin et al.   PLoS One

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic obesity and nutraceuticals

(2011) K. P. Conroy et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: modulation by endogenous omega-3 fatty acid-derived lipid mediators

(2011) Joan Clària   Frontiers in Immunology

A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells

(2010) Nicholas Ferrell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Tumors on chips: oncology meets microfluidics

(2010) Donald Wlodkowic et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In vitro human digestion models for food applications

(2010) Sun Jin Hur et al.   FOOD CHEMISTRY

Immunological substance testing on human lymphatic micro-organoids in vitro

(2010) Christoph Giese et al.   JOURNAL OF BIOTECHNOLOGY

A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System

(2010) Luca Cucullo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?

(2010) Roberta Paolinelli et al.   PHARMACOLOGICAL RESEARCH

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

An open-access microfluidic model for lung-specific functional studies at an air-liquid interface

(2009) Divya D. Nalayanda et al.   BIOMEDICAL MICRODEVICES

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fatty acids and postprandial inflammation

(2009) Andrew N Margioris   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota

(2009) Shigemitsu Tanaka et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

(2009) Astrid Spruss et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions

(2009) Jeongyun Kim et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

On the Origin of The Immune System

(2009) J. Travis   SCIENCE

Cell Culture Models in Microfluidic Systems

(2008) Ivar Meyvantsson et al.   Annual Review of Analytical Chemistry

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

Can cancer be reversed by engineering the tumor microenvironment?

(2008) Donald E. Ingber   SEMINARS IN CANCER BIOLOGY

Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human health

(2008) Volker Mai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS