Overexpression of Glutathione S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

(2023) Yulin Zhao et al.   Journal of Agricultural and Food Chemistry

Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9

(2023) Xiang Chen et al.   DRUG METABOLISM AND DISPOSITION

Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers

(2022) Bangtian Xu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models

(2022) Sun Joo Cha et al.   DEVELOPMENTAL CELL

Efficacy of auranofin as an inhibitor of desmoid progression

(2022) Kan Ito et al.   Scientific Reports

The Emerging Roles of Rad51 in Cancer and Its Potential as a Therapeutic Target

(2022) Ziyi Wang et al.   Frontiers in Oncology

CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis

(2022) Zhimin Chen et al.   Frontiers in Oncology

Myricetin as a Potential Adjuvant in Chemotherapy: Studies on the Inhibition of Human Glutathione Transferase A1–1

(2022) Mohammed Hamed Alqarni et al.   Biomolecules

Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation

(2022) Ying Li et al.   Journal of Agricultural and Food Chemistry

Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1

(2022) Panagiota Pantiora et al.   Antioxidants

TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

(2021) Zhou Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

(2021) Qiujie Wang et al.   Cell Death & Disease

Glutathione S-Transferases in Cancer

(2021) Rahul Raj Singh et al.   Antioxidants

The Interaction of the Flavonoid Fisetin with Human Glutathione Transferase A1-1

(2021) Mohammed Hamed Alqarni et al.   Metabolites

Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells

(2021) Shu-Yu Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin

(2021) Jing Zhang et al.   Journal of Ovarian Research

Potential Role of GST-π in Lung Cancer Stem Cell Cisplatin Resistance

(2021) Wenjun Wang et al.   Biomed Research International

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

(2020) Yiyue Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Water-Soluble Esters of Nitrobenzoxadiazole-Based GSTP1-1 Inhibitors for Cancer Treatment

(2020) Veronica Di Paolo et al.   BIOCHEMICAL PHARMACOLOGY

Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol

(2020) Dimitrios Tsikas   ANALYTICAL BIOCHEMISTRY

Glutathione S-Transferase Mu-3 Predicts a Better Prognosis and Inhibits Malignant Behavior and Glycolysis in Pancreatic Cancer

(2020) Shunda Wang et al.   Frontiers in Oncology

Bis‐conjugation of Bioactive Molecules to Cisplatin‐like Complexes through (2,2′‐Bipyridine)‐4,4′‐Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen

(2020) Lorenzo Biancalana et al.   CHEMISTRY-A EUROPEAN JOURNAL

Glutathione transferase Omega 1‐1 (GSTO1‐1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH‐SY5Y

(2019) Chonticha Saisawang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors

(2019) Weiyang Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

(2019) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Glutathione S ‐transferase omega 1 inhibition activates JNK ‐mediated apoptotic response in breast cancer stem cells

(2019) Kanakaraju Manupati et al.   FEBS Journal

Structure of a serine-type glutathione S-transferase of Ceriporiopsis subvermispora and identification of the enzymatically important non-canonical residues by functional mutagenesis

(2019) Wan Hasnidah Wan Osman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models

(2019) Na He et al.   ANALYTICAL CHEMISTRY

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

(2019) Alessio Bocedi et al.   Nutrients

Glutathionylation: a regulatory role of glutathione in physiological processes

(2018) Kristina Dominko et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Protein S -glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells

(2018) Daun Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug metabolizing enzymes and their inhibitors' role in cancer resistance

(2018) Shelly Pathania et al.   BIOMEDICINE & PHARMACOTHERAPY

ESR Resolves the C Terminus Structure of the Ligand-free Human Glutathione S-Transferase A1-1

(2018) Matthew J. Lawless et al.   BIOPHYSICAL JOURNAL

6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound

(2018) Huan-huan Sha et al.   BIOSCIENCE REPORTS

The multifaceted role of glutathione S-transferases in cancer

(2018) Anupam Chatterjee et al.   CANCER LETTERS

GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer

(2018) Alberto Checa-Rojas et al.   Oncotarget

A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells

(2018) Yuko Shishido et al.   CHEMBIOCHEM

Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors

(2018) Marija Pljesa-Ercegovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

(2018) Yangbo Feng et al.   Cancer Medicine

Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance

(2017) Xin Wang et al.   EXPERIMENTAL CELL RESEARCH

Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer

(2017) Su-jin Yang et al.   GENE

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

(2017) Chiara Fulci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Identification of Sensitivity Predictors of Neoadjuvant Chemotherapy for the Treatment of Adenocarcinoma of Gastroesophageal Junction

(2017) Shoumiao Li et al.   ONCOLOGY RESEARCH

Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases

(2017) Sun Joo Cha et al.   Oxidative Medicine and Cellular Longevity

Glutathione S-transferase A1 mediates nicotine-induced lung cancer cell metastasis by promoting epithelial-mesenchymal transition

(2017) Wei Wang et al.   Experimental and Therapeutic Medicine

Cytokine-Induced Killer Cells Modulates Resistance to Cisplatin in the A549/DDP Cell Line

(2017) Lili Yang et al.   Journal of Cancer

Structure, function and disease relevance of Omega-class glutathione transferases

(2016) Philip G. Board et al.   ARCHIVES OF TOXICOLOGY

Potent anti-proliferative actions of a non-diuretic glucosamine derivative of ethacrynic acid

(2016) Surendra R. Punganuru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Glutathione-S-transferases in neurological problems

(2016) Anil Kumar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

(2016) Wayne Harshbarger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

(2016) Camilla Palumbo et al.   Journal of Translational Medicine

A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1)

(2016) L. A. Crawford et al.   Molecular BioSystems

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme

(2016) Lorien J. Parker et al.   PROTEIN SCIENCE

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

(2016) Kavya Ramkumar et al.   Nature Communications

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

(2015) Grazia Graziani et al.   BIOCHEMICAL PHARMACOLOGY

Isoenzyme- and Allozyme-Specific Inhibitors: 2,2′-Dihydroxybenzophenones and Their Carbonyl N-Analogues that Discriminate between Human Glutathione Transferase A1-1 and P1-1 Allozymes

(2015) Foteini M. Pouliou et al.   Chemical Biology & Drug Design

Ezatiostat hydrochloride for the treatment of myelodysplastic syndromes

(2015) Daruka Mahadevan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

GSTA1 , GSTM1 , GSTP1 and GSTT1 polymorphisms in progressive myoclonus epilepsy: A Serbian case–control study

(2015) Marko Ercegovac et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A novel orally active water-soluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

(2015) Anastasia De Luca et al.   Oncotarget

Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis

(2015) Zhipeng Wang et al.   Scientific Reports

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

(2015) Jong-Lyel Roh et al.   Oncotarget

Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences

(2014) Vlastimil Dohnal et al.   ARCHIVES OF TOXICOLOGY

Roles of GST-π and polβ Genes in Chemoresistance of Esophageal Carcinoma Cells

(2014) Yue Tang et al.   Asian Pacific Journal of Cancer Prevention

2,2′-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1

(2014) Fereniki D. Perperopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

(2014) Simendra Singh   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Differential involvement of glutathione S-transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids

(2014) Chaker Attaoua et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

(2014) A De Luca et al.   Cell Death & Disease

Protein glutathionylation in health and disease

(2013) Pietro Ghezzi   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of P-glycoprotein and Glutathione S-transferase-pi mediated resistance by fluoxetine in MCF-7/ADM cells

(2013) Ye Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer

(2013) Ming Geng et al.   Diagnostic Pathology

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Multidrug Resistance in Primary Tumors and Metastases in Patients with Esophageal Squamous Cell Carcinoma

(2013) Fang Qiang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Glutathione transferases, regulators of cellular metabolism and physiology

(2012) Philip G. Board et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry

(2012) Alexandra J. Clipson et al.   CHEMISTRY-A EUROPEAN JOURNAL

A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin

(2012) Anastasia De Luca et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

(2012) Margarida Castro-Caldas et al.   MOLECULAR NEUROBIOLOGY

Human cytosolic glutathione transferases: structure, function, and drug discovery

(2012) Baojian Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling

(2012) XIANJUAN KOU et al.   Oncology Letters

Mechanisms of Altered Redox Regulation in Neurodegenerative Diseases—Focus on S-Glutathionylation

(2011) Elizabeth A. Sabens Liedhegner et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

(2011) Lorien J. Parker et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interactions of glutathione transferases with 4-hydroxynonenal

(2011) Larissa M. Balogh et al.   DRUG METABOLISM REVIEWS

Sigma-class glutathione transferases

(2011) Jack U. Flanagan et al.   DRUG METABOLISM REVIEWS

Glutathione transferases: a structural perspective

(2011) Aaron Oakley   DRUG METABOLISM REVIEWS

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Potent and Selective Inhibitors of GlutathioneS-Transferase Omega 1 That Impair Cancer Drug Resistance

(2011) Katsunori Tsuboi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

(2010) Aditi Pandya Martin et al.   CANCER BIOLOGY & THERAPY

Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity

(2010) S. Piaggi et al.   CARCINOGENESIS

Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

(2010) E Laborde   CELL DEATH AND DIFFERENTIATION

Cys-141 glutathionylation of human p53: Studies using specific polyclonal antibodies in cancer samples and cell lines

(2010) Mohd. A. Yusuf et al.   FREE RADICAL BIOLOGY AND MEDICINE

Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease

(2010) Thomas Thum et al.   LIVER INTERNATIONAL

Identification of Glutathione S -Transferase Pi as a Protein Involved in Parkinson Disease Progression

(2009) Min Shi et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

(2009) Azra Raza et al.   Journal of Hematology & Oncology

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

(2009) Daniel A Bachovchin et al.   NATURE BIOTECHNOLOGY

Oral vs. bath PUVA using 8-methoxypsoralen for chronic palmoplantar eczema

(2009) Stanislava Tzaneva et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Protein S-glutathionylation: a regulatory device from bacteria to humans

(2009) Isabella Dalle-Donne et al.   TRENDS IN BIOCHEMICAL SCIENCES

Detoxification reactions: Relevance to aging

(2008) Piotr Zimniak   AGEING RESEARCH REVIEWS

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients

(2008) Wei Shang et al.   BMC NEUROSCIENCE

Overcoming Glutathione S-Transferase P1-Related Cisplatin Resistance in Osteosarcoma

(2008) M. Pasello et al.   CANCER RESEARCH

Glutathione Transferase: New Model for Glutathione Activation

(2008) Daniel F. A. R. Dourado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mammalian Cytosolic Glutathione Transferases

(2008) Daniel Dourado et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Novel Role for GlutathioneS-Transferase π

(2008) Danyelle M. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY