Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import

(2015) Mingshan Niu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Piperlongumine is a novel nuclear export inhibitor with potent anticancer activity

(2015) Mingshan Niu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway

(2015) Feng Wang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer

(2015) Ketan Patel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine

(2015) Ha-Na Lee et al.   MOLECULES AND CELLS

Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown

(2014) Jianli Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells

(2014) Hyeon-Ok Jin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of I B  Kinase, Leading to Suppression of NF- B-Regulated Gene Products

(2014) J. G. Han et al.   MOLECULAR CANCER THERAPEUTICS

Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities

(2014) Yuanyuan Liu et al.   Nanoscale

Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

(2014) Tae Hyong Kim et al.   NEURO-ONCOLOGY

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

(2014) U Bharadwaj et al.   ONCOGENE

Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor

(2013) Sang Min Lim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Piperlongumine induces inhibition of the ubiquitin–proteasome system in cancer cells

(2013) Malin Jarvius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

(2013) Ju Mei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

(2013) Shanshan Pei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells

(2013) Serge Ginzburg et al.   PROSTATE

Synthesis of piperlogs and analysis of their effects on cells

(2013) Zarko V. Boskovic et al.   TETRAHEDRON

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine

(2013) H. Randhawa et al.   TOXICOLOGY IN VITRO

Piperlongumine induces autophagy by targeting p38 signaling

(2013) Y Wang et al.   Cell Death & Disease

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

(2012) Seong-Su Han et al.   LEUKEMIA RESEARCH

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

(2012) D. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Potent and Selective Inhibitors of GlutathioneS-Transferase Omega 1 That Impair Cancer Drug Resistance

(2011) Katsunori Tsuboi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Magnetic Bead Processor for Rapid Evaluation and Optimization of Parameters for Phosphopeptide Enrichment

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

multiplierz: an extensible API based desktop environment for proteomics data analysis

(2009) Jignesh R Parikh et al.   BMC BIOINFORMATICS

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

(2009) L. Federici et al.   CANCER RESEARCH